{"id":76826,"date":"2024-07-19T11:00:32","date_gmt":"2024-07-19T02:00:32","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=76826"},"modified":"2024-07-19T11:28:49","modified_gmt":"2024-07-19T02:28:49","slug":"%e6%96%b0%e3%81%97%e3%81%84%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e6%a7%8b%e9%80%a0%e3%82%92%e7%99%ba%e8%a6%8b","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/76826","title":{"rendered":"\u4eca\u306f\u5931\u308f\u308c\u305f\u53e4\u4ee3\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u3092\u767a\u898b"},"content":{"rendered":"<h1 style=\"text-align: center;\">\u4eca\u306f\u5931\u308f\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u304c\u89e3\u304d\u660e\u304b\u3059<br \/>\n\u300cRNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u300d\u3068\u300c\u30ea\u30dc\u30bd\u30fc\u30e0\u30bf\u30f3\u30d1\u30af\u8cea\u300d\u306e\u9032\u5316\u7684\u7e4b\u304c\u308a<\/h1>\n<h2><strong>\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8<\/strong><\/h2>\n<ul>\n<li>\u5730\u7403\u4e0a\u306e\u751f\u547d\u306fDNA\u306e\u907a\u4f1d\u60c5\u5831\u304b\u3089\u6a5f\u80fd\u5206\u5b50\u3067\u3042\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5408\u6210\u3059\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u6a5f\u69cb\u3092\u5171\u901a\u3057\u3066\u6301\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u306e\u3088\u3046\u306a\u7cbe\u5de7\u306a\u30b7\u30b9\u30c6\u30e0\u304c\u3069\u306e\u3088\u3046\u306b\u8a95\u751f\u3057\u305f\u304b\u306f\u3088\u304f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/li>\n<li>\u672c\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u6a5f\u69cb\u3067\u50cd\u304f\u591a\u7a2e\u591a\u69d8\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u306b\u7740\u76ee\u3057\u3001\u3053\u308c\u3089\u30bf\u30f3\u30d1\u30af\u8cea\u9593\u306e\u9032\u5316\u306e\u5b9f\u9a13\u7684\u518d\u73fe\u3092\u8a66\u307f\u305f\u3068\u3053\u308d\u3001\u5168\u304f\u65b0\u3057\u3044\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u300cDZBB\u300d\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002<\/li>\n<li>\u3053\u306e\u300cDZBB\u300d\u3092\u4ecb\u3057\u3066RNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u3084\u30ea\u30dc\u30bd\u30fc\u30e0\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u306b\u91cd\u8981\u306a\u8907\u6570\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u3078\u3068\u9032\u5316\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u3092\u5b9f\u9a13\u7684\u306b\u78ba\u304b\u3081\u307e\u3057\u305f\u3002<\/li>\n<li>\u9ce5\u3068\u6050\u7adc\u306e\u9032\u5316\u7684\u95a2\u9023\u6027\u3092\u793a\u3057\u305f\u59cb\u7956\u9ce5\u306e\u3088\u3046\u306b\u3001\u300cDZBB\u300d\u306f\u8907\u6570\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9032\u5316\u7684\u7e4b\u304c\u308a\u3092\u793a\u3059\u30df\u30c3\u30b7\u30f3\u30b0\u30ea\u30f3\u30af\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u8a00\u3048\u307e\u3059\u3002<\/li>\n<li>\u672c\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u3057\u305f\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u95a2\u308f\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9032\u5316\u306f\u3001\u4eca\u5f8c\u3001\u751f\u547d\u304c\u3069\u306e\u3088\u3046\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u6a5f\u69cb\u3092\u7372\u5f97\u3057\u3066\u304d\u305f\u304b\u3092\u63a2\u308b\u4e0a\u3067\u91cd\u8981\u306a\u9053\u6a19\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<hr \/>\n<p>\u65e9\u7a32\u7530\u5927\u5b66<a href=\"https:\/\/www.waseda.jp\/fhum\/\" target=\"_blank\" rel=\"noopener\">\u4eba\u9593\u79d1\u5b66\u5b66\u8853\u9662<\/a>\u306e<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100003760_ja.html\" target=\"_blank\" rel=\"noopener\">\u516b\u6728 \u5275\u592a\uff08\u3084\u304e \u305d\u3046\u305f\uff09<\/a> \u8b1b\u5e2b\uff08\u7406\u5316\u5b66\u7814\u7a76\u6240\uff08\u7406\u7814\uff09\u751f\u547d\u6a5f\u80fd\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u5ba2\u54e1\u7814\u7a76\u54e1\uff09\u3068<a href=\"https:\/\/www.riken.jp\/\" target=\"_blank\" rel=\"noopener\">\u7406\u5316\u5b66\u7814\u7a76\u6240<\/a>\uff08\u7406\u7814\uff09\u751f\u547d\u6a5f\u80fd\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc \u7530\u4e0a \u4fca\u8f14\uff08\u305f\u304c\u307f \u3057\u3085\u3093\u3059\u3051\uff09\u30c1\u30fc\u30e0\u30ea\u30fc\u30c0\u30fc\u306e\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u9032\u5316\u306e\u30df\u30c3\u30b7\u30f3\u30b0\u30ea\u30f3\u30af\u3068\u306a\u308b\u65b0\u3057\u3044\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u3092\u767a\u898b\u3057\u3001\u3053\u308c\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u7cfb\u306b\u91cd\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u306e\u9032\u5316\u3092\u5b9f\u9a13\u7684\u306b\u518d\u73fe\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<br \/>\n\u672c\u7814\u7a76\u6210\u679c\u306fSpringer Nature\u793e\u304c\u51fa\u7248\u3059\u308b\u300e<a href=\"https:\/\/www.nature.com\/ncomms\/\" target=\"_blank\" rel=\"noopener\">Nature communications<\/a>\u300f\uff08\u8ad6\u6587\u540d\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41467-024-50013-9\" target=\"_blank\" rel=\"noopener\">An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins<\/a>\uff09\u306b\u3066\u30012024\u5e747\u670818\u65e5\uff08\u6728\uff09\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u3067\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4>\uff08\uff11\uff09\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068\uff08\u79d1\u5b66\u53f2\u7684\u30fb\u6b74\u53f2\u7684\u306a\u80cc\u666f\u306a\u3069\uff09<\/h4>\n<p>\u751f\u547d\u306b\u3068\u3063\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u6c34\u306e\u6b21\u306b\u591a\u3044\u69cb\u6210\u7269\u8cea\u3067\u3042\u308a\u3001\u751f\u547d\u6d3b\u52d5\u306b\u306f\u6b20\u304b\u305b\u306a\u3044\u6a5f\u80fd\u5206\u5b50\u3067\u3059\u3002\u6211\u3005\u306e\u7d30\u80de\u5185\u3067\u306f\u907a\u4f1d\u60c5\u5831\u7269\u8cea\u3067\u3042\u308bDNA\u304b\u3089\u300c\u8ee2\u5199\u53cd\u5fdc\u300d\u306b\u3088\u3063\u3066RNA\u5206\u5b50\u304c\u4f5c\u3089\u308c\u3001\u305d\u306eRNA\u304b\u3089\u300c\u7ffb\u8a33\u53cd\u5fdc\u300d\u306b\u3088\u3063\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4f5c\u3089\u308c\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u591a\u304f\u306e\u7814\u7a76\u3067\u3001\u3053\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u6a5f\u69cb\u306e\u8a73\u7d30\u306a\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e\u304c\u9032\u3081\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u592a\u53e4\u306e\u5730\u7403\u4e0a\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u6a5f\u69cb\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u6210\u7acb\u3057\u3066\u304d\u305f\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u591a\u304f\u306e\u8b0e\u304c\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br 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\u03b2-barrel\uff08DPBB\uff09\u69cb\u9020\u3001\u30ea\u30dc\u30bd\u30fc\u30e0\u30bf\u30f3\u30d1\u30af\u8ceaL3\u304c\u6301\u3063\u3066\u3044\u308b\u2461RIFT 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id=\"attachment_78081\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-78081 size-full\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig1.png\" alt=\"\" width=\"3788\" height=\"1381\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig1.png 3788w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig1-610x222.png 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig1-940x343.png 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig1-768x280.png 768w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig1-1536x560.png 1536w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig1-2048x747.png 2048w\" sizes=\"auto, (max-width: 3788px) 100vw, 3788px\" \/><p class=\"wp-caption-text\">\u56f3\uff11\uff1aRNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u3068\u30ea\u30dc\u30bd\u30fc\u30e0\u3092\u69cb\u6210\u3059\u308b\uff14\u3064\u306e\u03b2\u30d0\u30ec\u30eb\u69cb\u9020\u3068\u63d0\u5531\u3055\u308c\u308b\u9032\u5316\u7684\u95a2\u4fc2\u6027<\/p><\/div>\n<h4>\uff08\uff12\uff09\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/h4>\n<p>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u516b\u6728\u3089\u306fDPBB\u69cb\u9020\u304c\uff17\u7a2e\u985e\u306e\u30a2\u30df\u30ce\u9178\u309243\u500b\u7e4b\u3052\u305f\u5358\u7d14\u306a\u30da\u30d7\u30c1\u30c9\u3067\u518d\u69cb\u6210\u3067\u304d\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u5358\u7d14\u306a\u30da\u30d7\u30c1\u30c9\u306f\u6c34\u6eb6\u6db2\u4e2d\u3067\u306f\u7279\u5b9a\u306e\u69cb\u9020\u3092\u5f62\u6210\u3067\u304d\u307e\u305b\u3093\u304c\u3001\u30de\u30ed\u30f3\u9178\u3084\u30ea\u30f3\u30b4\u9178\u306a\u3069\u306e\u6709\u6a5f\u9178\u3092\u542b\u3080\u6eb6\u6db2\u4e2d\u3067\u306f\u7d50\u6676\u5316\u3057\u3066DPBB\u69cb\u9020\u3092\u4f5c\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3057\u305f\uff08\u56f3\uff12\u5de6\uff09\uff08Yagi et al., JACS, 2021\uff09\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u3053\u306e\u5358\u7d14\u306a\u30da\u30d7\u30c1\u30c9\u304c\u786b\u9178\u30a4\u30aa\u30f3\u3092\u542b\u3080\u6761\u4ef6\u3067\u3082\u7d50\u6676\u3092\u5f62\u6210\u3057\u3001DPBB\u3068\u306f\u7570\u306a\u308b\u03b2\u30d0\u30ec\u30eb\u69cb\u9020\u3092\u4f5c\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u03b2\u30d0\u30ec\u30eb\u69cb\u9020\u306f\u3053\u308c\u307e\u3067\u81ea\u7136\u754c\u3067\u306f\u898b\u3064\u304b\u3063\u3066\u3044\u306a\u3044\u5168\u304f\u65b0\u3057\u3044\u69cb\u9020\u3067\u3042\u308a\u3001\u7acb\u4f53\u69cb\u9020\u3092\u6a21\u5f0f\u7684\u306b\u8868\u3059\u3068\u30ae\u30ea\u30b7\u30e3\u6587\u5b57\u306eZ\u306b\u4f3c\u305f\u7279\u5fb4\u7684\u306a\u30eb\u30fc\u30d7\u69cb\u9020\u3092\uff12\u3064\u6301\u3064\u3053\u3068\u304b\u3089\u3001\u516b\u6728\u3089\u306fDouble-zeta \u03b2-barrel \uff08DZBB\uff09\u69cb\u9020\u3068\u540d\u3065\u3051\u307e\u3057\u305f\uff08\u56f3\uff12\u53f3\uff09\u3002\u3064\u307e\u308a\u3001\u3053\u306e\u5358\u7d14\u306a\u30da\u30d7\u30c1\u30c9\u306f\u540c\u3058\u914d\u5217\u3067\u3082\u7570\u306a\u308b\u6761\u4ef6\u3067\u306f\u7570\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u3092\u4f5c\u308bMetamorphic\u30bf\u30f3\u30d1\u30af\u8cea<sup>\uff0a2<\/sup>\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<div id=\"attachment_78082\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-78082 size-full\" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig2-scaled.jpg\" alt=\"\" width=\"2560\" height=\"654\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig2-scaled.jpg 2560w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig2-610x156.jpg 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig2-940x240.jpg 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig2-768x196.jpg 768w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig2-1536x393.jpg 1536w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig2-2048x523.jpg 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><p class=\"wp-caption-text\">\u56f3\uff12\uff1a\u5358\u7d14\u306a\u30da\u30d7\u30c1\u30c9\u306b\u3088\u308bDPBB\u578b\u3068DZBB\u578b\u306e\u7d50\u6676\u69cb\u9020\u3068\u30c8\u30dd\u30ed\u30b8\u30fc\u56f3\u3002\u4e21\u8005\u3067\u7279\u306b\u7570\u306a\u308b\u30eb\u30fc\u30d7\u69cb\u9020\u3092\u30d4\u30f3\u30af\u3067\u30cf\u30a4\u30e9\u30a4\u30c8\u3057\u3066\u3044\u308b<\/p><\/div>\n<p>\u307e\u305f\u3001\u3053\u306eDZBB\u69cb\u9020\u306f\u30ea\u30dc\u30bd\u30fc\u30e0\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u542b\u307e\u308c\u308bRIFT\u69cb\u9020\u30fbOB\u69cb\u9020\uff08\u56f3\uff11\u4e2d\u306e\u2461\u3068\u2462\u306e\u69cb\u9020\uff09\u3068\u69cb\u9020\u985e\u4f3c\u6027\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001DZBB\u578b\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089RIFT\u578b\u69cb\u9020\u30fbOB\u69cb\u9020\u3078\u306e\u5909\u63db\u3092\u5b9f\u9a13\u7684\u306b\u8a66\u307f\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001DZBB\u2015RIFT\u69cb\u9020\u9593\u306e\u5909\u63db\u306f\uff11\u3064\u306e\u77ed\u3044\u914d\u5217\u306e\u6b20\u5931\u3001DZBB\u2015OB\u69cb\u9020\u9593\u306e\u5909\u63db\u306f\u4e00\u3064\u306e\u77ed\u3044\u914d\u5217\u633f\u5165\u3068\uff15\u3064\u306e\u30a2\u30df\u30ce\u9178\u7f6e\u63db\u306e\u307f\u3067\u9054\u6210\u3057\u3046\u308b\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u4f5c\u6210\u3057\u305fOB\u578b\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u6539\u5909\u4f53\u3092\u5faa\u74b0\u7f6e\u63db\uff08circular permutation\uff09<sup>*3<\/sup>\u3055\u305b\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306fSH3\u69cb\u9020\uff08\u56f3\uff11\u4e2d\u306e\u2463\u306e\u69cb\u9020\uff09\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3082\u5b9f\u8a3c\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u9032\u5316\u306e\u5b9f\u9a13\u306f\u3001DPBB\u3001RIFT\u3001OB\u3001SH3\u306e\uff14\u3064\u306e\u7570\u306a\u308b\u03b2\u30d0\u30ec\u30eb\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u304c\u540c\u3058\u7956\u5148\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u9032\u5316\u3057\u3066\u304d\u305f\u3053\u3068\u3001\u305d\u306e\u9032\u5316\u306e\u904e\u7a0b\u3067\u306fDZBB\u3068\u3044\u3046\u4eca\u306f\u5931\u308f\u308c\u305f\u9032\u5316\u4e2d\u9593\u4f53\u69cb\u9020\u304c\u3042\u3063\u305f\u53ef\u80fd\u6027\u3092\u5f37\u304f\u793a\u5506\u3057\u307e\u3059\uff08\u56f3\uff13\uff09\u3002\u3053\u306e\u7d50\u679c\u306f\u3001\u300c\u8ee2\u5199\u53cd\u5fdc\u300d\u3092\u3064\u304b\u3055\u3069\u308bRNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u3068\u300c\u7ffb\u8a33\u53cd\u5fdc\u300d\u3092\u53f8\u308b\u30ea\u30dc\u30bd\u30fc\u30e0\u304c\u5171\u901a\u306e\u7956\u5148\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u8a95\u751f\u3057\u305f\u3053\u3068\u3092\u88cf\u4ed8\u3051\u308b\u8a3c\u62e0\u3060\u3068\u3044\u3048\u307e\u3059\u3002<br \/>\n\u52a0\u3048\u3066\u3001\u672c\u7814\u7a76\u3067\u306f\u5f93\u6765\u8003\u3048\u3089\u308c\u3066\u304d\u305f\u3088\u308a\u3082\u5c11\u306a\u3044\u907a\u4f1d\u5b50\u5909\u7570\u3060\u3051\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u306e\u9032\u5316\u304c\u8d77\u3053\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u5f93\u3063\u3066\u3001\u52d5\u7269\u306e\u591a\u69d8\u5316\u304c\u6025\u901f\u306b\u9032\u3093\u3060\u30ab\u30f3\u30d6\u30ea\u30a2\u7206\u767a\u306e\u3088\u3046\u306b\u3001\u975e\u5e38\u306b\u77ed\u3044\u6642\u9593\u3067\u3053\u308c\u3089\uff14\u7a2e\u306e\u03b2\u30d0\u30ec\u30eb\u69cb\u9020\u304c\u8a95\u751f\u3057\u305f\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<div id=\"attachment_78083\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-78083 \" src=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig3.jpg\" alt=\"\" width=\"901\" height=\"538\" srcset=\"https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig3.jpg 2452w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig3-610x364.jpg 610w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig3-940x561.jpg 940w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig3-768x459.jpg 768w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig3-1536x917.jpg 1536w, https:\/\/www.waseda.jp\/inst\/research\/assets\/uploads\/2024\/06\/yagi-fig3-2048x1223.jpg 2048w\" sizes=\"auto, (max-width: 901px) 100vw, 901px\" \/><p class=\"wp-caption-text\">\u56f3\uff13\uff1a\u5b9f\u9a13\u7684\u306b\u518d\u73fe\u3057\u305fDZBB\u69cb\u9020\u304b\u3089\u4ed6\u306e\u03b2\u30d0\u30ec\u30eb\u69cb\u9020\u3078\u306e\u9032\u5316\u306e\u6a21\u5f0f\u56f3<\/p><\/div>\n<h4>\uff08\uff13\uff09\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3084\u793e\u4f1a\u7684\u5f71\u97ff<\/h4>\n<p>\u672c\u7814\u7a76\u3067\u306f\u73fe\u5b58\u3059\u308b\uff14\u7a2e\u985e\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020(DPBB\u3001RIFT\u3001OB\u3001SH3)\u306e\u9032\u5316\u30d7\u30ed\u30bb\u30b9\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u306f\u4eca\u5f8c\u3001\u30ea\u30dc\u30bd\u30fc\u30e0\u3084RNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306a\u3069\u306e\u5de8\u5927\u306a\u5206\u5b50\u304c\u3069\u306e\u3088\u3046\u306b\u8a95\u751f\u3057\u3066\u304d\u305f\u306e\u304b\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u6a5f\u69cb\u304c\u3069\u306e\u3088\u3046\u306b\u8a95\u751f\u3057\u3066\u304d\u305f\u306e\u304b\u3068\u3044\u3063\u305f\u8b0e\u3092\u63a2\u308b\u4e0a\u3067\u91cd\u8981\u306a\u9053\u6a19\u306b\u306a\u308b\u3068\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u307e\u305f\u3001\u53e4\u4ee3\u306e\u03b2\u30d0\u30ec\u30eb\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9032\u5316\u306f\u975e\u5e38\u306b\u77ed\u3044\u671f\u9593\u306b\u5b8c\u4e86\u3057\u3066\u3044\u305f\u53ef\u80fd\u6027\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u521d\u671f\u9032\u5316\u3092\u63a2\u6c42\u3059\u308b\u4e0a\u3067\u91cd\u8981\u306a\u8996\u70b9\u3092\u4e0e\u3048\u308b\u3082\u306e\u3068\u8a00\u3048\u307e\u3059\u3002<br \/>\n\u73fe\u5728\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u3092\u8a08\u7b97\u79d1\u5b66\u7684\u306b\u4e88\u6e2c\u3059\u308b\u6280\u8853\u304c\u6025\u901f\u306b\u767a\u9054\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u767a\u898b\u3057\u305fDZBB\u69cb\u9020\u306f\u6700\u5148\u7aef\u306e\u6280\u8853\u3092\u6301\u3063\u3066\u3057\u3066\u3082\u305d\u306e\u69cb\u9020\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u672c\u7814\u7a76\u6210\u679c\u306f\u751f\u547d\u9032\u5316\u5206\u91ce\u3060\u3051\u3067\u306a\u304f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u79d1\u5b66\u306e\u5206\u91ce\u306e\u767a\u5c55\u306b\u3082\u8ca2\u732e\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>\uff08\uff14\uff09\u4eca\u5f8c\u306e\u8ab2\u984c<\/h4>\n<p>\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u7279\u7570\u7684\u306a\u69cb\u9020\u3092\u5f62\u6210\u3057\u6a5f\u80fd\u3092\u679c\u305f\u3059\u3053\u3068\u3067\u751f\u547d\u6d3b\u52d5\u3092\u652f\u3048\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u53e4\u4ee3\u751f\u547d\u306e\u9032\u5316\u306e\u8b0e\u3092\u89e3\u304f\u305f\u3081\u306b\u306f\u3001\u69cb\u9020\u3060\u3051\u3067\u306a\u304f\u305d\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u306b\u3064\u3044\u3066\u3082\u691c\u8a0e\u3057\u3066\u3044\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u518d\u69cb\u6210\u3057\u305f\u03b2\u30d0\u30ec\u30eb\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u90e8\u3082DNA\u3084RNA\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u4eca\u5f8c\u3001\u3053\u308c\u3089\u306e\u03b2\u30d0\u30ec\u30eb\u30bf\u30f3\u30d1\u30af\u8cea\u304cDNA\u3084RNA\u3068\u3069\u306e\u3088\u3046\u306b\u7d50\u5408\u3057\u3001\u3069\u306e\u3088\u3046\u306b\u6a5f\u80fd\u3059\u308b\u304b\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u304f\u3053\u3068\u3067\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u6838\u9178\u306b\u3088\u308b\u5171\u9032\u5316\u306e\u6b74\u53f2\u3082\u89e3\u660e\u3067\u304d\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<h4>\uff08\uff15\uff09\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8<\/h4>\n<p>\u8fd1\u5e74\u3001\u8a08\u7b97\u79d1\u5b66\u3092\u5229\u7528\u3057\u305f\u751f\u547d\u9032\u5316\u306e\u7814\u7a76\u304c\u6d3b\u767a\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u4e0a\u3067\u4e88\u6e2c\u3055\u308c\u308b\u751f\u547d\u73fe\u8c61\u304c\u672c\u5f53\u304b\u3069\u3046\u304b\u306f\u3001\u5b9f\u9a13\u3092\u3057\u3066\u307f\u306a\u3044\u3068\u5206\u304b\u308a\u307e\u305b\u3093\u3002\u672c\u7814\u7a76\u3067\u3082\u5b9f\u9a13\u3092\u3057\u3066\u521d\u3081\u3066DZBB\u69cb\u9020\u3092\u767a\u898b\u3067\u304d\u3001\u3055\u3089\u306b\u306f\u591a\u69d8\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u3078\u306e\u9032\u5316\u306e\u9053\u7b4b\u3092\u518d\u73fe\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u300c\u751f\u547d\u306e\u8d77\u6e90\u300d\u3068\u3044\u3046\u7a76\u6975\u306e\u554f\u3044\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u5730\u9053\u306a\u5b9f\u9a13\u7684\u691c\u8a3c\u304c\u6975\u3081\u3066\u91cd\u8981\u3067\u3042\u308b\u3068\u611f\u3058\u307e\u3059\u3002<\/p>\n<h4>\uff08\uff16\uff09\u7528\u8a9e\u89e3\u8aac<\/h4>\n<p><strong>\u203b1\u3000\u03b2\u30d0\u30ec\u30eb\u578b\u69cb\u9020<\/strong><br \/>\n\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7279\u5fb4\u7684\u306a\u5206\u5b50\u69cb\u9020\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u03b2\u30b7\u30fc\u30c8\u69cb\u9020\u304c\u4e38\u307e\u3063\u3066\u6a3d\u306e\u3088\u3046\u306a\u69cb\u9020\u3092\u3057\u3066\u3044\u308b\u3002<\/p>\n<p><strong>\u203b2\u3000Metamorphic\u30bf\u30f3\u30d1\u30af\u8cea<\/strong><br \/>\n\u540c\u3058\u30a2\u30df\u30ce\u9178\u914d\u5217\u304b\u3089\u6210\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u540c\u3058\uff13\u6b21\u5143\u7684\u306a\u69cb\u9020\u3078\u3068\u6298\u308a\u7573\u307e\u308c\u308b\u3068\u4e00\u822c\u7684\u306b\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u307e\u308c\u306b\u540c\u3058\u30a2\u30df\u30ce\u9178\u914d\u5217\u3067\u3042\u3063\u3066\u3082\u8907\u6570\u306e\u69cb\u9020\u3092\u5f62\u6210\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5b58\u5728\u3059\u308b\u3002\u3053\u306e\u3088\u3046\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306fMetamorphic\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u547c\u3070\u308c\u3066\u3044\u308b\u3002<\/p>\n<p><strong>\u203b3\u3000\u5faa\u74b0\u7f6e\u63db\uff08circular permutation\uff09<\/strong><br \/>\n\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6301\u3064N\u672b\u7aef\u5074\u3082\u3057\u304f\u306fC\u672b\u7aef\u5074\u306e\u914d\u5217\u9818\u57df\u304c\u5207\u308a\u51fa\u3055\u308c\u3001\u7570\u306a\u308b\u672b\u7aef\u5074\u306b\u518d\u63a5\u7d9a\u3055\u308c\u308b\u5909\u7570\u306e\u540d\u79f0\u3002<\/p>\n<h4>\uff08\uff17\uff09\u8ad6\u6587\u60c5\u5831<\/h4>\n<p>\u96d1\u8a8c\u540d\uff1a<a href=\"https:\/\/www.nature.com\/ncomms\/\" target=\"_blank\" rel=\"noopener\">Nature Communications<\/a><br \/>\n\u8ad6\u6587\u540d\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41467-024-50013-9\" target=\"_blank\" rel=\"noopener\">An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins<\/a><br \/>\n\u57f7\u7b46\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a<a href=\"https:\/\/w-rdb.waseda.jp\/html\/100003760_ja.html\" target=\"_blank\" rel=\"noopener\">\u516b\u6728 \u5275\u592a<\/a>\uff08\u65e9\u7a32\u7530\u5927\u5b66\u4eba\u9593\u79d1\u5b66\u5b66\u8853\u9662\u3001\u7406\u5316\u5b66\u7814\u7a76\u6240\u751f\u547d\u6a5f\u80fd\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff09\u3001\u7530\u4e0a \u4fca\u8f14\uff08\u7406\u5316\u5b66\u7814\u7a76\u6240\u751f\u547d\u6a5f\u80fd\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff09<br \/>\n\u63b2\u8f09\u65e5\u6642\uff08\u73fe\u5730\u6642\u9593\uff09\uff1a2024\u5e747\u670818\u65e5 10:00<br \/>\n\u63b2\u8f09\u65e5\u6642\uff08\u65e5\u672c\u6642\u9593\uff09\uff1a2024\u5e747\u670818\u65e5 18:00<br \/>\n\u63b2\u8f09URL\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41467-024-50013-9\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/s41467-024-50013-9<\/a><br \/>\nDOI\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41467-024-50013-9\">10.1038\/s41467-024-50013-9<\/a><\/p>\n<h4>\uff08\uff18\uff09\u7814\u7a76\u52a9\u6210<\/h4>\n<ul>\n<li>\u7814\u7a76\u8cbb\u540d\uff1a\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\/\u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d\u3000\u82e5\u624b\u7814\u7a76<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a<a href=\"https:\/\/kaken.nii.ac.jp\/ja\/grant\/KAKENHI-PROJECT-20K15854\/\" target=\"_blank\" rel=\"noopener\">\u5358\u7d14\u306a\u30da\u30d7\u30c1\u30c9\u304b\u3089\u6c4e\u7528\u7684\u306a\u7956\u5148\u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a9\u30fc\u30eb\u30c9\u3078\u306e\u9032\u5316<\/a><br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u516b\u6728 \u5275\u592a\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/li>\n<li>\u7814\u7a76\u8cbb\u540d\uff1a\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\/\u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d \u57fa\u76e4\u7814\u7a76(B)<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a<a href=\"https:\/\/kaken.nii.ac.jp\/grant\/KAKENHI-PROJECT-18H01328\/\" target=\"_blank\" rel=\"noopener\">\u521d\u671f\u751f\u547d\u306b\u304a\u3051\u308bRNA\u30fb\u30bf\u30f3\u30d1\u30af\u8cea\u5171\u9032\u5316\u30d7\u30ed\u30bb\u30b9\u306e\u518d\u73fe<\/a><br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u516b\u6728 \u5275\u592a\uff08\u65e9\u7a32\u7530\u5927\u5b66\uff09<\/li>\n<li>\u7814\u7a76\u8cbb\u540d\uff1a\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\/\u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d \u57fa\u76e4\u7814\u7a76(B)<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a<a href=\"https:\/\/kaken.nii.ac.jp\/grant\/KAKENHI-PROJECT-22H01346\/\" target=\"_blank\" rel=\"noopener\">\u975e\u751f\u547d\u7684\u539f\u59cb\u30bf\u30f3\u30d1\u30af\u8cea\u8a95\u751f\u53ef\u80fd\u6027\u306e\u63a2\u7d22<\/a><br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u7530\u4e0a \u4fca\u8f14\uff08\u7406\u5316\u5b66\u7814\u7a76\u6240\uff09<\/li>\n<li>\u7814\u7a76\u8cbb\u540d\uff1a\u30a2\u30b9\u30c8\u30ed\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u30bb\u30f3\u30bf\u30fc\u3000\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u7814\u7a76<br \/>\n\u7814\u7a76\u8ab2\u984c\u540d\uff1a\u30bb\u30f3\u30c8\u30e9\u30eb\u30c9\u30b0\u30de\u3092\u62c5\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u7fa4\u306e\u96a0\u3055\u308c\u305f\u9032\u5316\u95a2\u4fc2<br \/>\n\u7814\u7a76\u4ee3\u8868\u8005\u540d\uff08\u6240\u5c5e\u6a5f\u95a2\u540d\uff09\uff1a\u7530\u4e0a \u4fca\u8f14\uff08\u7406\u5316\u5b66\u7814\u7a76\u6240\uff09<\/li>\n<\/ul>\n<h4>\uff08\uff19\uff09\u7814\u7a76\u8005\u306e\u7565\u6b74<\/h4>\n<p><a href=\"https:\/\/w-rdb.waseda.jp\/html\/100003760_ja.html\" target=\"_blank\" rel=\"noopener\">\u516b\u6728 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