{"id":72858,"date":"2022-04-01T16:33:03","date_gmt":"2022-04-01T07:33:03","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=72858"},"modified":"2022-07-08T17:12:47","modified_gmt":"2022-07-08T08:12:47","slug":"catalytic-reductive-ring-opening-of-epoxides-enabled-by-zirconocene-and-photoredox-catalysis%ef%bc%882022%e5%b9%b44%e6%9c%88%ef%bc%9achem%e8%aa%8c%e6%8e%b2%e8%bc%89%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/72858","title":{"rendered":"Catalytic Reductive Ring Opening of Epoxides Enabled by Zirconocene and Photoredox Catalysis\uff08Published in Chem, April 2022\uff09"},"content":{"rendered":"<table class=\"table table-bordered table-colored-tbhd\" style=\"height: 550px; width: 100%; border-collapse: collapse; border-style: solid;\" border=\"1\">\n<tbody>\n<tr style=\"height: 78px;\">\n<td style=\"width: 19.5804%; height: 78px;\">Journal Title<br \/>\n\/\u63b2\u8f09\u30b8\u30e3\u30fc\u30ca\u30eb\u540d<\/td>\n<td class=\"xl231\" style=\"width: 75.6497%; height: 15.75pt;\" width=\"205\" height=\"21\">Chem<\/td>\n<\/tr>\n<tr style=\"height: 65px;\">\n<td style=\"width: 19.5804%; height: 80px;\">Publication Year and Month<br \/>\n\/\u63b2\u8f09\u5e74\u6708<\/td>\n<td style=\"width: 75.6497%; height: 80px;\">April, 2022<\/td>\n<\/tr>\n<tr style=\"height: 55px;\">\n<td style=\"width: 19.5804%; height: 79px;\">Paper Title<br \/>\n\/\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb<\/td>\n<td style=\"width: 75.6497%; height: 79px;\">Catalytic Reductive Ring Opening of Epoxides Enabled by Zirconocene and Photoredox Catalysis<\/td>\n<\/tr>\n<tr style=\"height: 85px;\">\n<td style=\"width: 19.5804%; height: 85px;\">DOI<br \/>\n\/\u8ad6\u6587DOI<\/td>\n<td style=\"width: 75.6497%; height: 85px;\"><a href=\"https:\/\/doi.org\/10.1016\/j.chempr.2022.04.010\">10.1016\/j.chempr.2022.04.010<\/a><\/td>\n<\/tr>\n<tr style=\"height: 59px;\">\n<td style=\"width: 19.5804%; height: 80px;\">Author of Waseda University<br \/>\n\/\u672c\u5b66\u306e\u8457\u8005<\/td>\n<td style=\"width: 75.6497%; height: 80px;\">AIDA,Kazuhiro(Student,\u00a0Faculty of Science and Engineering, School of Advanced Science and Engineering):First Author<\/p>\n<p>YAMAGUCHI, Junichiro (Professor,\u00a0Faculty of Science and Engineering, School of Advanced Science and Engineering):Corresponding Author<\/p>\n<p><a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001406_ja.html\">\u65e9\u7a32\u7530\u5927\u5b66\u7814\u7a76\u8005\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff08\u65e5\u672c\u8a9e\uff09<\/a><\/p>\n<p><a href=\"https:\/\/w-rdb.waseda.jp\/html\/100001406_en.html\">Waseda University Researchers Database(English)<\/a><\/td>\n<\/tr>\n<tr style=\"height: 68px;\">\n<td style=\"width: 19.5804%; height: 86px;\">Related Websites<br \/>\n\/\u95a2\u9023Web<\/td>\n<td style=\"width: 75.6497%; height: 86px;\">&#8211;<\/td>\n<\/tr>\n<tr style=\"height: 138px;\">\n<td style=\"width: 19.5804%; height: 148px;\">Abstract<br \/>\n\/\u6284\u9332<\/td>\n<td style=\"width: 75.6497%; height: 148px;\">The reductive ring opening of epoxides is a powerful transformation to convert readily accessible epoxides into a diverse array of\u00a0valuable alcohols, including pharmaceuticals, agrochemicals, and functional polymers. Although significant progress has been made, the established methods were limited to titanocene-catalyzed reactions. Herein, we report an unprecedented zirconocene-catalyzed ring opening of epoxide enabled by photoredox catalysis. Compared with the conventional ring-opening methods, the present protocol exhibited reverse regioselectivity to afford more substituted alcohols via putative less-stable radicals. This reaction is remarkably mild and smoothly cleaves C\u2013O bonds in molecules with a variety of functional groups, including natural products. We believe that the finding that changing the metal center in metallocene influences the energy profile of ring opening is a significant advance and provides a new perspective in radical chemistry with group IV metals.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Journal Title \/\u63b2\u8f09\u30b8\u30e3\u30fc\u30ca\u30eb\u540d Chem Publication Year and Month \/\u63b2\u8f09\u5e74\u6708 April, 2022 Paper Title \/\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb Catalytic Reduct [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[218,217],"class_list":["post-72858","post","type-post","status-publish","format-standard","hentry","tag-impact-en","tag-impact"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/72858","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=72858"}],"version-history":[{"count":2,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/72858\/revisions"}],"predecessor-version":[{"id":72984,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/72858\/revisions\/72984"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=72858"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=72858"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=72858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}