{"id":68948,"date":"2017-02-27T13:34:58","date_gmt":"2017-02-27T04:34:58","guid":{"rendered":"https:\/\/www.waseda.jp\/inst\/research\/?p=68948"},"modified":"2019-01-25T13:36:26","modified_gmt":"2019-01-25T04:36:26","slug":"creating-ethers-from-esters-new-method-for-developing-anti-cancer-drugs-and-antimalarial-medications","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news-en\/68948","title":{"rendered":"Creating ethers from esters? New method for developing anti-cancer drugs and antimalarial medications"},"content":{"rendered":"<h1>Success in world\u2019s first decarbonylative diaryl ether synthesis by Pd and Ni catalysis<\/h1>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-48888 size-full\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2017\/02\/20170222fig0.png\" alt=\"20170222fig0\" width=\"1118\" height=\"450\" \/>Researchers developed a catalytic decarbonlyative etherification of aromatic esters using a nickel or palladium catalyst with their enabling diphosphine ligand to give the corresponding diaryl ethers. In other words, they succeeded in developing the world&#8217;s first catalyst for removing carbon from esters, acid-derived chemical compounds where one or more OH group is replaced by an O-alkyl group, to create ethers, organic compounds with an oxygen atom attached to alkyl or aryl groups. This is the first of its kind in the world and provides a new method for pharmaceutical research in developing anti-cancer drugs and antimalarial medications.<\/p>\n<p>A paper on this research was published in the online version of <a href=\"http:\/\/dx.doi.org\/10.1021\/jacs.7b00049\"><em>Journal of the American Chemical Society<\/em><\/a> on February 21.<\/p>\n<div id=\"attachment_48890\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-48890\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2017\/02\/20170222fig2-610x282.png\" alt=\"20170222fig2\" width=\"325\" height=\"150\" \/><p class=\"wp-caption-text\">Above: The conventional method of intermolecular cross-coupling reaction of aryl halides and phenols with a copper or palladium catalyst Below: The newly developed method using nickel or palladium catalyst<\/p><\/div>\n<p>Intermolecular cross-coupling reaction of aryl halides and phenols with a copper or palladium catalyst is the conventional method for constructing a diaryl ether functional group, but due to the costly expenses and concerns regarding waste management, there has been a demand for a more effective new method.<\/p>\n<div id=\"attachment_48891\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-48891\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2017\/02\/20170222fig3-610x206.png\" alt=\"20170222fig3\" width=\"325\" height=\"110\" \/><p class=\"wp-caption-text\">Decarbonylative ether synthesis by nickel or palladium catalysis<\/p><\/div>\n<p>In this research, the catalyst successfully removed carbon monoxide from aromatic esters to form the <strong>Ar<\/strong>-O-<strong>Ar\u2019<\/strong> decarbonlyative diaryl ether synthesis. Using this method, achieving diaryl ethers from over 30 different kinds of aromatic esters becomes possible.<\/p>\n<p>As a result, inexpensive and easily obtainable aromatic esters can synthesize diaryl ethers, contributing to future developments in pharmaceutical products.<\/p>\n<p>For more information on this research, contact <a href=\"http:\/\/junyamaguchi@waseda.jp\">Junichiro Yamaguchi<\/a>, associate professor in the Department of Applied Chemistry at Waseda University.<\/p>\n<h5>On the publication<\/h5>\n<ul>\n<li>Journal: Journal of the American Chemical Society<\/li>\n<li>Title: <a class=\"addicn\" href=\"http:\/\/dx.doi.org\/10.1021\/jacs.7b00049\" target=\"_blank\" rel=\"noopener\">Decarbonylative Diaryl Ether Synthesis by Pd and Ni Catalysis<\/a><\/li>\n<li>Authors: Ryosuke Takise, Ryota Isshiki, Kei Muto, Kenichiro Itami, and Junichiro Yamaguchi<\/li>\n<li>Published on: (Just Accepted Manuscripts)<\/li>\n<li>DOI: 10.1021\/jacs.7b00049<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Success in world\u2019s first decarbonylative diaryl ether synthesis by Pd and Ni catalysis Researchers developed a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":68949,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[95],"tags":[136,179],"class_list":["post-68948","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en","tag-pressrelease-en","tag-research-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/68948","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=68948"}],"version-history":[{"count":0,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/68948\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media\/68949"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=68948"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=68948"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=68948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}