{"id":61032,"date":"2018-09-12T13:33:58","date_gmt":"2018-09-12T04:33:58","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=61032"},"modified":"2018-10-19T15:14:24","modified_gmt":"2018-10-19T06:14:24","slug":"first-demonstration-of-protonic-biotransducer-connecting-to-living-mitochondria","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news-en\/61032","title":{"rendered":"First demonstration of protonic biotransducer connecting to living mitochondria"},"content":{"rendered":"<p>Scientists from Waseda University and Tokyo University of Agriculture and Technology developed a protonic biotransducer that monitors and modulates H+ concentration (pH) by controlling the flow of H+ between a conductive polymer (sulfonated polyaniline) and solution. By connecting the biotransducer to a living mitochondria, they became the first to successfully modulate the rate of ATP synthesis.<br \/>\n<div id=\"attachment_61035\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-61035\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/09\/41598_2018_28435_Fig1_HTML.jpg\" alt=\"\" width=\"900\" height=\"347\" \/><p class=\"wp-caption-text\">A protonic biotransducer controlling ATP synthesis in mitochondria<\/p><\/div><br \/>\n&#8220;In future applications, this device could integrate with pH dependent biological samples (such as membrane proteins and transporters) and may allow further control of biological functions,&#8221; says <a href=\"http:\/\/researchers.waseda.jp\/profile\/en.cd000e00ff88e151d466b7ab7f56107e.html\">Takeo Miyake<\/a>, associate professor of bioelectronics at Waseda University and member of the research team.<br \/>\nThis study was published in <em>Scientific Reports<\/em> on July 12, 2018.<\/p>\n<h4>Reference<\/h4>\n<ul>\n<li>Article title: <a href=\"https:\/\/www.nature.com\/articles\/s41598-018-28435-5\">A protonic biotransducer controlling mitochondrial ATP synthesis<\/a><\/li>\n<li>Authors: Z. Zhang, H. Kashiwagi, S. Kimura, S. Kong, Y. Ohta &amp; <a href=\"miyake@waseda.jp\">T. Miyake<\/a><\/li>\n<li>Published in <em>Scientific Reports<\/em> on July 12, 2018<\/li>\n<li>DOI\uff1a10.1038\/s41598-018-28435-5<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Scientists from Waseda University and Tokyo University of Agriculture and Technology developed a protonic biot [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":66105,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[95],"tags":[73,79,179],"class_list":["post-61032","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en","tag-general-en","tag-health-en","tag-research-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/61032","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=61032"}],"version-history":[{"count":2,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/61032\/revisions"}],"predecessor-version":[{"id":66106,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/61032\/revisions\/66106"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media\/66105"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=61032"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=61032"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=61032"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}