{"id":60484,"date":"2018-07-24T14:00:41","date_gmt":"2018-07-24T05:00:41","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=60484"},"modified":"2018-10-19T13:09:16","modified_gmt":"2018-10-19T04:09:16","slug":"%e7%94%9f%e5%91%bd%e6%b4%bb%e5%8b%95%e3%81%ae%e7%87%83%e6%96%99%e3%80%8catp%e3%80%8d%e3%82%92%e8%a6%b3%e5%af%9f%e3%81%99%e3%82%8b%ef%bc%93%e8%89%b2%e3%81%ae%e8%9b%8d%e5%85%89%e3%82%bb%e3%83%b3","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/60484","title":{"rendered":"\u751f\u547d\u6d3b\u52d5\u306e\u71c3\u6599\u300cATP\u300d\u3092\u89b3\u5bdf\u3059\u308b\uff13\u8272\u306e\u86cd\u5149\u30bb\u30f3\u30b5\u30fc\u306e\u958b\u767a\u306b\u6210\u529f\u3000\u304c\u3093\u3084\u80a5\u6e80\u306e\u5275\u85ac\u958b\u767a\u3078\u306e\u8ca2\u732e\u306b\u671f\u5f85"},"content":{"rendered":"<h2>\u65e5\u672c\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u3001\u30a2\u30e1\u30ea\u30ab\u306e\u56fd\u969b\u5171\u540c\u7814\u7a76<\/h2>\n<h3>\u30dd\u30a4\u30f3\u30c8<\/h3>\n<ul>\n<li>\u7d30\u80de\u306e\u4e2d\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u4e2d\u5fc3\u3067\u3042\u308bATP\u3092\u30bb\u30f3\u30b7\u30f3\u30b0\u3059\u308b\u3001\u8d64\u30fb\u7dd1\u30fb\u9752\uff08RGB\uff09\u8272\u306e\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc\u306e\u958b\u767a\u306b\u6210\u529f<\/li>\n<li>\u5f93\u6765\u306e\u6280\u8853\u3067\u306f\u56f0\u96e3\u3067\u3042\u3063\u305f\u3001\u540c\u4e00\u7d30\u80de\u5185\u306e\u7570\u306a\u308b\u5834\u6240\u306eATP\u52d5\u614b\u306e\u540c\u6642\u89b3\u5bdf\u304c\u53ef\u80fd\u306b<\/li>\n<li>\u6d77\u5916\u306b\u3042\u308b\u65e5\u672c\u306e\u30e9\u30dc\u30fb\u65e9\u7a32\u7530\u30d0\u30a4\u30aa\u30b5\u30a4\u30a8\u30f3\u30b9\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u7814\u7a76\u6240\uff08WABIOS\uff09\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u3001\u65e5\u672c\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u3001\u30a2\u30e1\u30ea\u30ab\u306e\u56fd\u969b\u5171\u540c\u7814\u7a76<\/li>\n<\/ul>\n<p>\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u306e<a href=\"http:\/\/researchers.waseda.jp\/profile\/ja.3f88edc9917da6ea69dc420a7d67a96c.html\" target=\"_blank\" rel=\"noopener\">\u65b0\u4e95\u654f\uff08\u3042\u3089\u3044\u3055\u3068\u3057\uff09\u7814\u7a76\u9662\u8b1b\u5e2b<\/a>\u3068\u6771\u4eac\u5de5\u696d\u5927\u5b66 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\/>\n\u5730\u7403\u4e0a\u306e\u3042\u3089\u3086\u308b\u751f\u7269\u306f\u3001\u6804\u990a\u7d20\u306e\u5206\u89e3\u3092\u901a\u3057\u3066\u7372\u5f97\u3057\u305f\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u3001ATP\u306e\u5f62\u306b\u5909\u63db\u30fb\u4fdd\u5b58\u3057\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u3001ATP\u304b\u3089\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u53d6\u308a\u51fa\u3059\u3053\u3068\u3067\u3001\u751f\u547d\u4f53\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u306e\u4e2d\u306e\u69d8\u3005\u306a\u5316\u5b66\u53cd\u5fdc\u3092\u6ede\u308a\u306a\u304f\u9032\u884c\u3055\u305b\u305f\u308a\u3001\u5fc5\u8981\u306a\u5834\u6240\u306b\u5fc5\u8981\u306a\u7269\u8cea\u3092\u8f38\u9001\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u3092\u52d5\u304b\u3057\u305f\u308a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306eATP\u306e\u7d30\u80de\u5185\u306e\u5206\u5e03\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u7d30\u80de\u5185\u306eATP\u6fc3\u5ea6\u306e\u5909\u5316\u306e\u60c5\u5831\u3092\u86cd\u5149\u30b7\u30b0\u30ca\u30eb\uff08\u86cd\u5149\u306e\u660e\u308b\u3055\u306e\u5f37\u5f31\uff09\u306b\u5909\u63db\u3059\u308b\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc\u3092\u7d30\u80de\u306e\u4e2d\u306b\u5c0e\u5165\u3057\u3001\u86cd\u5149\u9855\u5fae\u93e1\u3092\u7528\u3044\u3066\u751f\u304d\u305f\u7d30\u80de\u3092\u89b3\u5bdf\u3059\u308b\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6280\u8853\u304c\u6700\u3082\u6709\u529b\u306a\u624b\u6cd5\u306e\uff11\u3064\u3067\u3059\u3002<br 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href=\"https:\/\/doi.org\/10.1002\/anie.201804304\" target=\"_blank\" rel=\"noopener\">Angewandte Chemie International Edition<\/a>\u300f\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u306b2018\u5e746\u670827\u65e5\u306b\u63b2\u8f09\u3055\u308c\u3001\u8fd1\u65e5\u4e2d\u306b\u7d19\u9762\u63b2\u8f09\u3055\u308c\u308b\u4e88\u5b9a\u3067\u3059\u3002<\/p>\n<h4>\uff081\uff09\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068<\/h4>\n<p>\u5730\u7403\u4e0a\u306e\u3042\u3089\u3086\u308b\u751f\u7269\u306f\u3001\u7cd6\u3001\u8102\u8cea\u3001\u30a2\u30df\u30ce\u9178\u306a\u3069\u306e\u6804\u990a\u7d20\u306e\u5206\u89e3\u3092\u901a\u3057\u3066\u7372\u5f97\u3057\u305f\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u3001\u30a2\u30c7\u30ce\u30b7\u30f3\u4e09\u30ea\u30f3\u9178\uff08ATP\uff09\u306e\u5f62\u306b\u5909\u63db\u3057\u3001\u4fdd\u5b58\u3057\u307e\u3059\u3002\u305d\u3057\u3066\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u3001ATP\u304b\u3089\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u53d6\u308a\u51fa\u3059\u3053\u3068\u3067\u3001\u751f\u547d\u4f53\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u306e\u4e2d\u306e\u69d8\u3005\u306a\u5316\u5b66\u53cd\u5fdc\u3092\u6ede\u308a\u306a\u304f\u9032\u884c\u3055\u305b\u305f\u308a\u3001\u5fc5\u8981\u306a\u5834\u6240\u306b\u5fc5\u8981\u306a\u7269\u8cea\u3092\u8f38\u9001\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u3092\u52d5\u304b\u3057\u305f\u308a\u3057\u3066\u3044\u307e\u3059\u3002ATP\u306f\u3001\u8a00\u308f\u3070\u3001\u751f\u547d\u6d3b\u52d5\u306e\u71c3\u6599\u3067\u3042\u308a\u3001\u7d30\u80de\u306e\u6a5f\u80fd\u3084\u6052\u5e38\u6027\u3092\u7dad\u6301\u3059\u308b\u4e0a\u3067\u6975\u3081\u3066\u91cd\u8981\u306a\u5206\u5b50\u3067\u3042\u308b\u3068\u8a00\u3048\u307e\u3059\u3002<br \/>\n\u3053\u306e\u305f\u3081\u3001\u751f\u7269\u5b66\u7814\u7a76\u306e\u5e45\u5e83\u3044\u9818\u57df\u306b\u304a\u3044\u3066\u3001\u7d30\u80de\u306e\u4e2d\u3067\u3001\u3069\u306e\u3088\u3046\u306bATP\u304c\u5206\u5e03\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u305d\u3057\u3066\u6642\u9593\u306b\u4f34\u3063\u3066\u3069\u3046\u5909\u5316\u3057\u3066\u3044\u304f\u306e\u304b\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u306f\u5927\u304d\u306a\u8ab2\u984c\u306e\uff11\u3064\u3067\u3059\u3002\u3053\u3046\u3057\u305f\u8ab2\u984c\u3092\u89e3\u6c7a\u3059\u308b\u305f\u3081\u306b\u7528\u3044\u3089\u308c\u308b\u306e\u304c\u3001\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u6280\u8853\u3067\u3059\u3002\u7d30\u80de\u306e\u4e2d\u3067\u8d77\u304d\u308b\u73fe\u8c61\u306e\u5909\u5316\u3092\u3001\u86cd\u5149\u30b7\u30b0\u30ca\u30eb\uff08\u4e3b\u306b\u3001\u86cd\u5149\u306e\u660e\u308b\u3055\u306e\u5f37\u5f31\uff09\u306b\u5909\u63db\u3059\u308b\u6975\u5c0f\u306e\u86cd\u5149\u30bb\u30f3\u30b5\u30fc\u3067\u7d30\u80de\u5185\u306e\u6ce8\u76ee\u5206\u5b50\u306e\u52d5\u614b\u3092\u86cd\u5149\u9855\u5fae\u93e1\u3067\u89b3\u5bdf\u3059\u308b\u624b\u6cd5\u3067\u3059\u3002\u73fe\u5728\u307e\u3067\u306b\u3001\u5e7e\u3064\u304b\u306e\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08ATeam; Imamura et al., PNAS, 2009. B-Queen; Yaginuma et al., Sci. Rep., 2014\uff09\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u5f93\u6765\u306e\u86cd\u5149\u30bb\u30f3\u30b5\u30fc\u3067\u306f\u3001\u4f7f\u7528\u3067\u304d\u308b\u8272\u306b\u5236\u9650\u304c\u3042\u308b\u305f\u3081\u3001\u540c\u3058\u7d30\u80de\u306e\u4e2d\u306e\u7570\u306a\u308b\u5834\u6240\uff08\u7d30\u80de\u5c0f\u5668\u5b98\u306a\u3069\uff09\u306eATP\u306e\u52d5\u614b\u3092\u540c\u6642\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u3084ATP\u4ee5\u5916\u306e\u4ed6\u306e\u30b7\u30b0\u30ca\u30eb\u5206\u5b50\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u52d5\u614b\u3092\u540c\u6642\u306b\u89b3\u5bdf\u3059\u308b\u3053\u3068\u306f\u539f\u7406\u7684\u306b\u56f0\u96e3\u3067\u3057\u305f\u3002<\/p>\n<h4>\uff082\uff09\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u958b\u767a\u3057\u305f\u624b\u6cd5<\/h4>\n<p>\u672c\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001ATP\u306e\u6fc3\u5ea6\u5909\u5316\u306b\u5fdc\u7b54\u3057\u3066\u3001\u86cd\u5149\u5f37\u5ea6\u304c\u5909\u5316\u3059\u308b\u5358\u8272\u578b\u306e\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7528\u3044\u305f\u65b0\u3057\u3044\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u4eca\u56de\u306e\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc\u306f\u3001\u6a19\u7684\u3068\u3059\u308bATP\u306b\u7279\u7570\u7684\u306b\u7d50\u5408\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\uff08ATP\u5408\u6210\u9175\u7d20\u306e\u4e00\u90e8\u306e\u03b5\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\uff09\u3068\u3001\u86cd\u5149\u3092\u767a\u3059\u308b\u8272\u7d20\u3092\u542b\u3080\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u30da\u30d7\u30c1\u30c9\u30ea\u30f3\u30ab\u30fc\u3092\u4ecb\u3057\u3066\u7e4b\u304c\u3063\u305f\u69cb\u9020\u3092\u3057\u3066\u3044\u307e\u3059\uff08\u56f3\uff11\u5de6\u53c2\u7167\uff09\u3002ATP\u6fc3\u5ea6\u306b\u5fdc\u7b54\u3057\u3066\u86cd\u5149\u5f37\u5ea6\u304c\u5927\u304d\u304f\u5909\u308f\u308b\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc\u3092\u5f97\u308b\u306b\u306f\u3001\u3053\u306e\u30da\u30d7\u30c1\u30c9\u30ea\u30f3\u30ab\u30fc\u306e\u9577\u3055\u3084\u3001\u69cb\u6210\u3059\u308b\u30a2\u30df\u30ce\u9178\u306e\u7a2e\u985e\u304c\u5927\u304d\u306a\u9375\u306a\u308a\u307e\u3059\u3002\u6700\u7d42\u7684\u306b\u3001\u3053\u306e\u30ea\u30f3\u30ab\u30fc\u3092\u72ec\u81ea\u306e\u624b\u6cd5\u3067\u6700\u9069\u5316\u3057\u3001\u9752\u8272(BFP)\u3001\u7dd1\u8272(Citrine)\u3001\u8d64\u8272(mApple)\u306eTurn-on\u578b\uff08\u203b\uff12\uff09\u306e\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc\u3092\u958b\u767a\u3001\u305d\u308c\u305e\u308c\u3001MaLionB, G, R\uff08<strong><u>M<\/u><\/strong>onitoring <strong><u>a<\/u><\/strong>TP <strong><u>L<\/u><\/strong>evel <strong><u>i<\/u><\/strong>ntensity based turn <strong><u>on<\/u><\/strong> indicators\uff09\u3068\u540d\u3065\u3051\u307e\u3057\u305f\u3002MaLionB\u3001MaLionG\u3001MaLionR\u306f\u3001\u305d\u308c\u305e\u308c\u3001\u86cd\u5149\u5f37\u5ea6\u304c90\uff05\u3001390\uff05\u3001350\uff05\u5897\u52a0\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u30bb\u30f3\u30b5\u30fc\u306e\u4f5c\u52d5\u3059\u308bATP\u306e\u6fc3\u5ea6\u57df\u3082\u30010.1\uff5e8\u30df\u30ea\u30e2\u30eb\u6fc3\u5ea6\u3067\u3001\u751f\u7406\u7684\u6761\u4ef6\u306eATP\u6fc3\u5ea6\u57df\u3068\u4e00\u81f4\u3057\u3066\u3044\u307e\u3059\u3002\u66f4\u306b\u3001\u3053\u306e\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc\u306f\u3001\u7d30\u80de\u306e\u4e2d\u306e\u72d9\u3063\u305f\u7d30\u80de\u5c0f\u5668\u5b98\u306a\u3069\u306b\u3001\u81ea\u7531\u81ea\u5728\u306b\u914d\u7f6e\u3067\u304d\u308b\u3053\u3068\u3082\u7279\u5fb4\u3067\u3059\u3002<\/p>\n<h4>\uff083\uff09\u4eca\u56de\u306e\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u7d50\u679c\u53ca\u3073\u77e5\u898b<\/h4>\n<p>\u4eca\u56de\u958b\u767a\u3057\u305f\u4e00\u9023\u306e\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc\uff08MaLions\uff09\u306b\u3088\u3063\u3066\u3001\u4eca\u307e\u3067\u306e\u6280\u8853\u3067\u306f\u6975\u3081\u3066\u56f0\u96e3\u3067\u3042\u3063\u305f\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u306e\u3067\u3001\u305d\u306e\u4e8b\u4f8b\u3092\uff12\u3064\u7d39\u4ecb\u3057\u307e\u3059\u3002<br \/>\n<div id=\"attachment_60485\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-60485\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/07\/20180724_fig1-610x337.png\" alt=\"\" width=\"610\" height=\"337\" \/><p class=\"wp-caption-text\">\u56f31\u3000ATP\u306e\u6fc3\u5ea6\u5909\u5316\u306b\u3088\u3063\u3066\u86cd\u5149\u5f37\u5ea6\u304c\u5909\u308f\u308bRGB\u30ab\u30e9\u30fc\u306e\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc<\/p><\/div><br \/>\n<strong><br \/>\n[A] <\/strong><strong>\u540c\u3058\u7d30\u80de\u306e\u4e2d\u306e\u7570\u306a\u308b\u5834\u6240\u306eATP\u306e\u52d5\u614b\u3092\u540c\u6642\u306b\u89b3\u5bdf\u3059\u308b\u8a66\u307f<\/strong><br \/>\n\u901a\u5e38\u3001\u52d5\u7269\u7d30\u80de\u306e\u5834\u5408\u3001ATP\u306f\u3001\u7d30\u80de\u8cea\u306b\u304a\u3051\u308b\u89e3\u7cd6\u7cfb\u3068\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3067\u306e\u9178\u5316\u7684\u30ea\u30f3\u9178\u5316\u306e\u4e21\u65b9\u306e\u7d4c\u8def\u304b\u3089\u5408\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u66f4\u306b\u3001\u5206\u5316\u3057\u305f\u7d30\u80de\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3067\u306eATP\u7523\u751f\u7cfb\u304c\u4e3b\u8981\u7d4c\u8def\u3067\u3042\u308b\u306e\u306b\u5bfe\u3057\u3001\u304c\u3093\u7d30\u80de\u3092\u306f\u3058\u3081\u3068\u3057\u305f\u5897\u6b96\u6027\u306e\u7d30\u80de\u3067\u306f\u3001\u89e3\u7cd6\u7cfb\u304c\u767a\u9054\u3057\u3066\u3044\u308b\u3068\u3044\u3063\u305f\u9055\u3044\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\uff08\u30ef\u30fc\u30d6\u30eb\u30b0\u52b9\u679c\uff08\u203b\uff13\uff09\uff09\u3002\u304c\u3093\u7d30\u80de\uff08HeLa\u7d30\u80de\uff09\u3068\u6b63\u5e38\u306a\u7d30\u80de\uff08\u8910\u8272\u8102\u80aa\u7d30\u80de\uff09\u306b\u3001\u7dd1\u8272\u306e\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc\uff08MaLionG\uff09\u3068\u8d64\u8272\u306e\u30bb\u30f3\u30b5\u30fc\uff08MaLionR\uff09\u3092\u3001\u305d\u308c\u305e\u308c\u3001\u7d30\u80de\u8cea\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u5c0e\u5165\u3057\u3001\u9855\u5fae\u93e1\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002\u89b3\u5bdf\u306e\u9014\u4e2d\u306b\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306eATP\u7523\u751f\u3092\u30aa\u30ea\u30b4\u30de\u30a4\u30b7\u30f3\u3067\u963b\u5bb3\u3057\u305f\u3068\u3053\u308d\u3001HeLa\u7d30\u80de\uff08\u203b\uff14\uff09\u3067\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306eATP\u6fc3\u5ea6\u6e1b\u5c11\u3068\u540c\u6642\u306b\u3001\u7d30\u80de\u8cea\u306eATP\u6fc3\u5ea6\u4e0a\u6607\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u73fe\u8c61\u306f\u3001\u6d3b\u767a\u306a\u89e3\u7cd6\u7cfb\u3092\u6301\u3064\u304c\u3093\u7d30\u80de\u304c\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306eATP\u7523\u751f\u306e\u963b\u5bb3\u306b\u3088\u308b\u7d30\u80de\u5168\u4f53\u3067\u306eATP\u6fc3\u5ea6\u306e\u4f4e\u4e0b\u306b\u5fdc\u7b54\u3057\u3001\u7d30\u80de\u8cea\u306eATP\u6fc3\u5ea6\u306e\u4e00\u904e\u7684\u306a\u4e0a\u6607\u306b\u3088\u308a\u88dc\u304a\u3046\u3068\u3057\u3066\u3044\u308b\u3068\u8003\u5bdf\u3057\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306eATP\u7523\u751f\u304c\u512a\u4f4d\u306a\u7d30\u80de\u306e\u4f8b\u3068\u3057\u3066\u3001\u4f8b\u3048\u3070\u8910\u8272\u8102\u80aa\u7d30\u80de\u3067\u306f\u3001\u7d30\u80de\u8cea\u306eATP\u6fc3\u5ea6\u4e0a\u6607\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u304c\u3093\u7d30\u80de\u3068\u6b63\u5e38\u306a\u7d30\u80de\u306e\u9055\u3044\u3092\u3001\u540c\u4e00\u7d30\u80de\u5185\u306eATP\u52d5\u614b\u3068\u3044\u3046\u8996\u70b9\u304b\u3089\u691c\u51fa\u3057\u305f\u521d\u3081\u3066\u306e\u4f8b\u3068\u8a00\u3048\u307e\u3059\u3002\u307e\u305f\u3001\u4e0a\u8a18\u306e\u4ed6\u306b\u3001\u5149\u5408\u6210\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u690d\u7269\uff08\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\uff09\u306eATP\u7523\u751f\u306e\u5897\u52a0\u3084\uff08\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u56fd\u7acb\u5927\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\uff09\u3001\u9ebb\u9154\u306b\u4f34\u3063\u3066\u6e1b\u5c11\u3059\u308bATP\u306e\u69d8\u5b50\u3092\u7dda\u866b\u3067\u6349\u3048\u308b\u3053\u3068\u306b\u3082\u6210\u529f\u3057\u3066\u304a\u308a\uff08\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u7dcf\u5408\u6587\u5316\u7814\u7a76\u79d1\u3068\u306e\u5171\u540c\u7814\u7a76\uff09\u3001\u958b\u767a\u3057\u305f\u30bb\u30f3\u30b5\u30fc\u304c\u3001\u52d5\u7269\u30fb\u690d\u7269\u306e\u6975\u3081\u3066\u5e83\u3044\u7bc4\u56f2\u306e\u751f\u7269\u7a2e\u306b\u9069\u7528\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u307e\u3057\u305f\u3002<br \/>\n<div id=\"attachment_60486\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-60486\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/07\/20180724_fig2-610x239.png\" alt=\"\" width=\"610\" height=\"239\" \/><p class=\"wp-caption-text\">\u56f32\u3000\u304c\u3093\u7d30\u80de\u306e\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306aATP\u306e\u6fc3\u5ea6\u5909\u5316\u3092\u6349\u3048\u305f\u6210\u529f\u4f8b<\/p><\/div><br \/>\n<strong>[B] ATP<\/strong><strong>\u3068\u305d\u308c\u4ee5\u5916\u306e\u30b7\u30b0\u30ca\u30eb\u306e\u52d5\u614b\u3092\u540c\u6642\u306b\u89b3\u5bdf\u3059\u308b\u8a66\u307f<\/strong><br \/>\n\u8910\u8272\u8102\u80aa\u7d30\u80de\u306f\u3001\u79c1\u9054\u306e\u4f53\u306e\u4e2d\u3067\u3001\u6052\u5e38\u6027\u3092\u4fdd\u3064\u305f\u3081\u306b\u71b1\u7523\u751f\u3092\u884c\u3046\u91cd\u8981\u306a\u7d30\u80de\u306e1\u3064\u3067\u3059\u3002\u79c1\u9054\u306f\u8910\u8272\u8102\u80aa\u7d30\u80de\u3092\u305d\u306e\u524d\u99c6\u7d30\u80de\u3088\u308a\u5206\u5316\u3055\u305b\uff08\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u56fd\u7acb\u5927\u5b66\u3001\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\uff09\u3001\u7d30\u80de\u8cea\u306b\u9752\u8272\u306e\u86cd\u5149\u30ab\u30eb\u30b7\u30a6\u30e0\u30bb\u30f3\u30b5\u30fc(B-GECO)\u3068\u7dd1\u8272\u306e\u86cd\u5149cAMP\u30bb\u30f3\u30b5\u30fc(Flamindo2)\u3001\u305d\u3057\u3066\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u8d64\u8272\u306e\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc(MaLionR)\u3092\u5c0e\u5165\u3057\u307e\u3057\u305f\u3002\u9855\u5fae\u93e1\u89b3\u5bdf\u4e2d\u306b\u3001\u03b2\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u53d7\u5bb9\u4f53\u3092\u30a4\u30bd\u30d7\u30ed\u30c6\u30ce\u30fc\u30eb\uff08\u203b\uff15\uff09\u3067\u523a\u6fc0\u3057\u305f\u3068\u3053\u308d\u3001cAMP\u304c\u4e0a\u6607\uff08Flamindo2\u306e\u86cd\u5149\u5f37\u5ea6\u304c\u6e1b\u5c11\u3002Flamindo2\u306fTurn-off\u578b\uff09\u3001\u7d9a\u3044\u3066\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306eATP\u304c\u7de9\u3084\u304b\u306b\u6e1b\u5c11\u3001\u66f4\u306b\u3001\u53cd\u5fdc\u306e\u5f8c\u534a\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u306e\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u69d8\u5b50\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u8910\u8272\u8102\u80aa\u7d30\u80de\u306f\u3001\u53d7\u5bb9\u4f53\u306e\u523a\u6fc0\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u305f\u7d30\u80de\u819c\u4e0a\u306e\u30a2\u30c7\u30cb\u30eb\u9178\u30b7\u30af\u30e9\u30fc\u30bc\uff08AC\uff09\u304ccAMP\u3092\u5408\u6210\u3057\u3001\u3053\u308c\u304c\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3068\u306a\u3063\u3066\u3001cAMP\u4f9d\u5b58\u6027\u306ePKA\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002\u305d\u306e\u5f8c\u3001\u8102\u80aa\u9178\u3092\u904a\u96e2\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u4e0a\u306e\u8131\u5171\u5f79\u30bf\u30f3\u30d1\u30af\u8ceaUCP1\u3068\u4f5c\u7528\u3057\u3066\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819c\u4e0a\u306e\u819c\u96fb\u4f4d\u306e\u5143\u3068\u306a\u308b\u30d7\u30ed\u30c8\u30f3\u6fc3\u5ea6\u52fe\u914d\u3092\u89e3\u6d88\u3055\u305bATP\u5408\u6210\u3092\u963b\u5bb3\u3057\u3001\u6700\u5f8c\u306b\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304b\u3089\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u304c\u6d41\u308c\u51fa\u3066\u304f\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\uff08\u8910\u8272\u8102\u80aa\u306e\u71b1\u7523\u751f\uff09\u3002\u751f\u7269\u5b66\u306e\u6559\u79d1\u66f8\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u3053\u306e\u3088\u3046\u306a\u7d30\u80de\u5185\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u6a21\u5f0f\u56f3\u306f\u3001\u300c\u6642\u9593\u300d\u304c\u6b62\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u5b9f\u969b\u306b\u306f\u3001\u7d30\u80de\u306e\u4e2d\u306f\u3001\u6642\u3005\u523b\u3005\u3068\u69d8\u3005\u306a\u56e0\u5b50\u304c\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306b\u5909\u5316\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u3001R,G,B\u3068\u3044\u3046\u30ab\u30e9\u30d5\u30eb\u306a\u30bb\u30f3\u30b5\u30fc\u3092\u958b\u767a\u3057\u305f\u3053\u3068\u3067\u3001\u6a21\u5f0f\u56f3\u3068\u3057\u3066\u63cf\u304b\u308c\u3066\u3044\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u4e00\u90e8\u3092\u672c\u6765\u306e\u59ff\u3068\u3057\u3066\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<br \/>\n<div id=\"attachment_60487\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-60487\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/07\/20180724_fig3-610x423.png\" alt=\"\" width=\"610\" height=\"423\" \/><p class=\"wp-caption-text\">\u56f33\u3000\u8910\u8272\u8102\u80aa\u7d30\u80de\u306e\u71b1\u7523\u751f\u306b\u95a2\u308f\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u306e\u53ef\u8996\u5316<\/p><\/div><\/p>\n<h4>(4)\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3068\u610f\u7fa9<\/h4>\n<p>\u4eca\u56de\u3001\u958b\u767a\u3057\u305f\u4e00\u9023\u306e\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc\u306f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u7cfb\u306e\u5909\u5316\u306b\u3064\u3044\u3066\u77e5\u308a\u305f\u3044\u3068\u3044\u3046\u30cb\u30fc\u30ba\u306b\u5bfe\u3057\u3066\u3001\u76f4\u611f\u7684\u306b\u5206\u304b\u308a\u3084\u3059\u3044\u30d3\u30b8\u30e5\u30a2\u30eb\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u7279\u306b\u3001\u85ac\u5264\u306e\u52b9\u679c\u3092\u8fc5\u901f\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u304c\u8981\u6c42\u3055\u308c\u308b\u3001\u304c\u3093\u3084\u80a5\u6e80\u306a\u3069\u306e\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u305f\u3081\u306e\u5275\u85ac\u958b\u767a\u306b\u304a\u3044\u3066\u5a01\u529b\u3092\u767a\u63ee\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u529b\u3084\u71b1\u306a\u3069\u306e\u7269\u7406\u7684\u306a\u523a\u6fc0\u306b\u4f34\u3046\u7d30\u80de\u306e\u5fdc\u7b54\u3092\u77e5\u308b\u3053\u3068\u3082\u3001\u533b\u7642\u6a5f\u5668\u958b\u767a\u306e\u5206\u91ce\u306b\u304a\u3044\u3066\u306f\u91cd\u8981\u3067\u3059\u3002\u5f93\u3063\u3066\u3001\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u5275\u85ac\u30fb\u533b\u7642\u6a5f\u5668\u958b\u767a\u306e\u69d8\u3005\u306a\u5206\u91ce\u306e\u7814\u7a76\u958b\u767a\u3092\u52a0\u901f\u3055\u305b\u308b\u3082\u306e\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<br \/>\n\u672c\u7814\u7a76\u306e\u5b9f\u65bd\u306b\u304a\u3044\u3066\u306f\u3001\u4e16\u754c\u306e\u7814\u7a76\u30cf\u30d6\u3067\u3042\u308b\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u30fb\u30d0\u30a4\u30aa\u30dd\u30ea\u30b9\u306b\u3042\u308b\u65e9\u7a32\u7530\u30d0\u30a4\u30aa\u30b5\u30a4\u30a8\u30f3\u30b9\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u7814\u7a76\u6240\uff08WABIOS\uff09\u304c\u6700\u5927\u9650\u306b\u6d3b\u7528\u3055\u308c\u307e\u3057\u305f\u3002\u73fe\u5730\u306e\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u56fd\u7acb\u5927\u5b66\uff08Raghunath\u535a\u58eb\u3084Ito\u535a\u58eb\u3089\uff09\u304b\u3089\u7814\u7a76\u8a66\u6599\u3092\u30b9\u30e0\u30fc\u30ba\u306b\u53d7\u3051\u53d6\u308a\u3001\u8fc5\u901f\u306bWABIOS\u306b\u3066\u5b9f\u9a13\u3092\u9042\u884c\u3057\u3064\u3064\u3001\u65e5\u5e38\u7684\u306b\u8b70\u8ad6\u3067\u304d\u305f\u3053\u3068\u304c\u3001\u672c\u7814\u7a76\u3092\u5b8c\u9042\u3059\u308b\u306e\u306b\u975e\u5e38\u306b\u91cd\u8981\u3067\u3057\u305f\u3002\u6700\u7d42\u7684\u306b\u672c\u5171\u540c\u7814\u7a76\u306f\u3001\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u7dcf\u5408\u6587\u5316\u7814\u7a76\u79d1\u3001\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u3078\u3068\u5e83\u304c\u308a\u3001\u4e16\u754c\u4e2d\u306e\u7814\u7a76\u8005\u3092\u5dfb\u304d\u8fbc\u3093\u3060\u56fd\u969b\u5171\u8457\u8ad6\u6587\u3068\u3057\u3066\u9054\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001WABIOS\u306f\u3001\u52b9\u7387\u826f\u304f\u56fd\u969b\u7684\u306a\u5171\u540c\u7814\u7a76\u3092\u5b9f\u65bd\u3067\u304d\u308b\u5834\u6240\u3067\u3042\u308b\u3053\u3068\u306b\u52a0\u3048\u3001\u73fe\u5730\u306e\u5927\u5b66\u30fb\u7814\u7a76\u6a5f\u95a2\u7b49\u304b\u3089\u72ec\u7acb\u3057\u305f\u7814\u7a76\u6240\u3067\u3042\u308b\u305f\u3081\u3001\u767a\u751f\u3057\u305f\u77e5\u8ca1\u306b\u95a2\u3057\u3066\u306f\u3001\u65e5\u672c\u5074\u306e\u7814\u7a76\u8005\u304c\u5358\u72ec\u3067\u305d\u306e\u6a29\u5229\u3092\u4e3b\u5f35\u3067\u304d\u308b\u3053\u3068\u3082\u7279\u5fb4\u3067\u3059\u3002\u3053\u3046\u3057\u305f\u7279\u6b8a\u6027\u3092\u6d3b\u304b\u3057\u3001\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc\u6750\u6599\u306e\u95a2\u9023\u3067\u51fa\u9858\u3057\u305f\u7279\u8a31\u306f\u3001\u672c\u5b66\u304c\u4e3b\u5c0e\u3067\u3001\u305d\u306e\u77e5\u8ca1\u3092\u4fdd\u8b77\u3057\u306a\u304c\u3089\u3001\u7814\u7a76\u3092\u9032\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u3053\u3046\u3057\u305f\u6d77\u5916\u306e\u7814\u7a76\u62e0\u70b9\u306f\u672c\u5b66\u306e\u5927\u304d\u306a\u5f37\u307f\u3067\u3042\u308a\u3001\u4eca\u5f8c\u4e00\u5c64\u3001\u65b0\u305f\u306a\u7814\u7a76\u6210\u679c\u3092\u767a\u4fe1\u3057\u3066\u3044\u304f\u72ec\u81ea\u306e\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h4>\uff085\uff09\u4eca\u5f8c\u306e\u8ab2\u984c<\/h4>\n<p>\u672c\u7814\u7a76\u6210\u679c\u3067\u306f\u3001\u304c\u3093\u7d30\u80de\u306e\u4e00\u90e8\u3068\u8910\u8272\u8102\u80aa\u7d30\u80de\u306b\u7126\u70b9\u304c\u5f53\u3066\u3089\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u4eca\u5f8c\u306f\u3001\u69d8\u3005\u306a\u7d30\u80de\u7a2e\u306eATP\u7523\u751f\u7d4c\u8def\u306e\u7279\u5fb4\u3092\u4f53\u7cfb\u7684\u306b\u7406\u89e3\u3057\u3066\u3044\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u4eca\u307e\u3067\u4ee5\u4e0a\u306b\u3001\u7523\u5b66\u3092\u554f\u308f\u305a\u3001\u591a\u5c90\u306b\u6e21\u308b\u5c02\u9580\u5206\u91ce\u306e\u7814\u7a76\u8005\u3068\u306e\u5171\u540c\u7814\u7a76\u304c\u5fc5\u9808\u3067\u3059\u3002\u7279\u306b\u3001\u8907\u6570\u306e\u7a2e\u985e\u306e\u304c\u3093\u7d30\u80de\u306e\u7279\u5fb4\u3092ATP\u7523\u751f\u7cfb\u306e\u8996\u70b9\u304b\u3089\u7db2\u7f85\u7684\u306b\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u3001\u5275\u85ac\u7814\u7a76\u306b\u5927\u304d\u306a\u30a4\u30f3\u30d1\u30af\u30c8\u3092\u4e0e\u3048\u308b\u3082\u306e\u3068\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>\uff086\uff09100\u5b57\u7a0b\u5ea6\u306e\u6982\u8981<\/h4>\n<p>\u7d30\u80de\u306e\u4e2d\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u4e2d\u5fc3\u3067\u3042\u308bATP\u3092\u30bb\u30f3\u30b7\u30f3\u30b0\u3059\u308b\u3001\u8d64\u30fb\u7dd1\u30fb\u9752\uff08RGB\uff09\u8272\u306e\u86cd\u5149ATP\u30bb\u30f3\u30b5\u30fc\u306e\u958b\u767a\u306b\u6210\u529f\u3002\u7d30\u80de\u5185\u306eATP\u306e\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306a\u59ff\u3092\u9ad8\u7cbe\u5ea6\u3001\u4e14\u3064\u3001\u7c21\u4fbf\u306b\u6349\u3048\u308b\u5f37\u529b\u306a\u30c4\u30fc\u30eb\u3068\u3057\u3066\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n<h4><strong>\uff087\uff09\u7528\u8a9e\u89e3\u8aac<\/strong><\/h4>\n<ul>\n<li><strong>\u203b\uff11\u3000\u30da\u30d7\u30c1\u30c9\u30ea\u30f3\u30ab\u30fc<\/strong>\uff1a\u672c\u7814\u7a76\u3067\u306f\u6570\u500b\uff5e\u6570\u5341\u500b\u306e\u30a2\u30df\u30ce\u9178\u304c\u9023\u7d50\u3057\u305f\u5206\u5b50\uff08\u30da\u30d7\u30c1\u30c9\uff09\u304c\u3001\uff12\u3064\u306e\u7570\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7e4b\u3052\u308b\u5f79\u5272\uff08\u30ea\u30f3\u30ab\u30fc\uff09\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u69cb\u6210\u3059\u308b\u30a2\u30df\u30ce\u9178\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066\u3001\u30da\u30d7\u30c1\u30c9\u30ea\u30f3\u30ab\u30fc\u306e\u67d4\u8edf\u6027\u3084\u525b\u76f4\u6027\u304c\u5909\u308f\u308a\u307e\u3059\u304c\u3001\u3053\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6700\u9069\u5316\u3059\u308b\u3053\u3068\u304c\u86cd\u5149\u30bb\u30f3\u30b5\u30fc\u306e\u958b\u767a\u306e\u91cd\u8981\u306a\u70b9\u306e1\u3064\u3067\u3059\u3002<\/li>\n<li><strong>\u203b\uff12\u3000Turn-on\u578b<\/strong>\uff1a\u5bfe\u8c61\u3068\u3059\u308b\u5206\u5b50\u3092\u691c\u51fa\u3057\u3066\u3001\u86cd\u5149\u5f37\u5ea6\u3092\u5909\u5316\u3055\u305b\u308b\u86cd\u5149\u30bb\u30f3\u30b5\u30fc\u306e\u5834\u5408\u3001\u86cd\u5149\u5f37\u5ea6\u304c\u5897\u52a0\u3059\u308b\u30bf\u30a4\u30d7\u306e\u30bb\u30f3\u30b5\u30fc\u3092\u201cTurn-on\u201d\u578b\u3001\u9006\u306b\u3001\u6e1b\u5c11\u3059\u308b\u30bf\u30a4\u30d7\u3092\u201dTurn-off\u201c\u578b\u3068\u547c\u3073\u307e\u3059\u3002<\/li>\n<li><strong>\u203b\uff13\u3000\u30ef\u30fc\u30d6\u30eb\u30b0\u52b9\u679c<\/strong>\uff1a\u7d30\u80de\u5185\u3067ATP\u304c\u5408\u6210\u3055\u308c\u308b\u7d4c\u8def\u3068\u3057\u3066\u3001\u89e3\u7cd6\u7cfb\u3068\u9178\u5316\u7684\u30ea\u30f3\u9178\u5316\u306e2\u3064\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u89e3\u7cd6\u7cfb\u306f\u7d30\u80de\u8cea\u3067\u884c\u308f\u308c\u3001\u30b0\u30eb\u30b3\u30fc\u30b91\u5206\u5b50\u304b\u3089ATP\u30922\u5206\u5b50\u5408\u6210\u3059\u308b\u306e\u306b\u5bfe\u3057\u3001\u9178\u5316\u7684\u30ea\u30f3\u9178\u5316\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3067\u884c\u308f\u308c\u3001ATP36\u5206\u5b50\u3092\u5408\u6210\u3057\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001ATP\u7523\u751f\u306e\u52b9\u7387\u306e\u70b9\u3067\u306f\u3001\u89e3\u7cd6\u7cfb\u3088\u308a\u3082\u9178\u5316\u7684\u30ea\u30f3\u9178\u5316\u306e\u65b9\u304c\u5727\u5012\u7684\u306b\u512a\u308c\u3066\u3044\u307e\u3059\u3002\u6b63\u5e38\u306a\u7d30\u80de\u306f\u3001\u9178\u5316\u7684\u30ea\u30f3\u9178\u5316\u306b\u4f9d\u5b58\u3057\u3066ATP\u7523\u751f\u3092\u884c\u3063\u3066\u3044\u308b\u306e\u306b\u5bfe\u3057\u3066\u3001\u304c\u3093\u7d30\u80de\u306f\u3001\u52b9\u7387\u306e\u60aa\u3044\u89e3\u7cd6\u7cfb\u306b\u4f9d\u5b58\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u53e4\u304f\u304b\u3089\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u30ef\u30fc\u30d6\u30eb\u30b0\u52b9\u679c\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<li><strong>\u203b\uff14\u3000HeLa\u7d30\u80de<\/strong>\uff1a\u30d2\u30c8\u5b50\u5bae\u9838\u764c\u7531\u6765\u306e\u7d30\u80de\u3002\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u751f\u7269\u5b66\u7684\u7814\u7a76\u3067\u7528\u3044\u3089\u308c\u308b\u30e2\u30c7\u30eb\u7d30\u80de\u3067\u3042\u308a\u3001\u86cd\u5149\u30bb\u30f3\u30b5\u30fc\u306e\u958b\u767a\u7814\u7a76\u306b\u304a\u3044\u3066\u306f\u3001\u751f\u7d30\u80de\u3067\u4f5c\u52d5\u3059\u308b\u304b\u3092\u691c\u8a0e\u3059\u308b\u76ee\u7684\u3067\u7528\u3044\u3089\u308c\u307e\u3059\u3002<\/li>\n<li><strong>\u203b\uff15\u3000\u30a4\u30bd\u30d7\u30ed\u30c6\u30ce\u30fc\u30eb<\/strong>\uff1a\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u03b2\u53d7\u5bb9\u4f53\u3092\u9078\u629e\u7684\u306b\u523a\u6fc0\u3059\u308b\u5206\u5b50\u3067\u3042\u308a\u3001Gs\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067cAMP\u3092\u7523\u751f\u3055\u305b\u307e\u3059\u3002<\/li>\n<\/ul>\n<h5><strong>\u8ad6\u6587\u60c5\u5831<\/strong><\/h5>\n<ul>\n<li>\u63b2\u8f09\u8a8c\uff1aAngewandte Chemie International Edition<\/li>\n<li>\u8ad6\u6587\u540d\uff1a<a href=\"https:\/\/doi.org\/10.1002\/anie.201804304\" target=\"_blank\" rel=\"noopener\">RGB-color intensiometric indicators to visualize spatiotemporal dynamics of ATP in single cells<\/a><\/li>\n<li>\u8457\u8005\u00a0 \uff1aSatoshi Arai\uff08\u65b0\u4e95\u654f\uff09, R\u00f3kus Kriszt, Kazuki Harada\uff08\u539f\u7530\u4e00\u8cb4\uff09, Liang-Sheng Looi, Shogo Matsuda\uff08\u677e\u7530\u7fd4\u543e\uff09, Devina Wongso, Satoshi Suo\uff08\u5468\u9632\u8aed\uff09, Shoichi Ishiura\uff08\u77f3\u6d66\u7ae0\u4e00\uff09, Yu-Hua Tseng, Michael Raghunath, Toshiro Ito\uff08\u4f0a\u85e4\u5bff\u6717\uff09, Takashi Tsuboi\uff08\u576a\u4e95\u8cb4\u53f8\uff09, Tetsuya 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":66144,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[145,178],"class_list":["post-60484","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-pressrelease","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/60484","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=60484"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/60484\/revisions"}],"predecessor-version":[{"id":66145,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/60484\/revisions\/66145"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media\/66144"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=60484"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=60484"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=60484"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}