{"id":57000,"date":"2018-02-02T13:32:50","date_gmt":"2018-02-02T04:32:50","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=57000"},"modified":"2018-10-19T14:21:50","modified_gmt":"2018-10-19T05:21:50","slug":"%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%82%84%e3%82%a2%e3%83%9f%e3%83%8e%e9%85%b8%e3%81%ae%e9%a3%9f%e4%ba%8b%e3%81%8c%e6%9c%ab%e6%a2%a2%e8%87%93%e5%99%a8%e3%81%ae%e4%bd%93%e5%86%85%e6%99%82","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/57000","title":{"rendered":"\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u30a2\u30df\u30ce\u9178\u306e\u98df\u4e8b\u304c\u672b\u68a2\u81d3\u5668\u306e\u4f53\u5185\u6642\u8a08\u3092\u540c\u8abf\u3055\u305b\u308b\u3000\u80a5\u6e80\u9632\u6b62\u3084\u7cd6\u5c3f\u75c5\u6cbb\u7642\u3078\u306e\u8ca2\u732e\u306b\u671f\u5f85"},"content":{"rendered":"<p>\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u306e<a href=\"https:\/\/researchers.waseda.jp\/profile\/ja.1aeecd51409d18fc39c8c3a7e1aa06a7.html\" 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\/>\n\u672c\u7814\u7a76\u306f\u3001\u98df\u4e8b\u5185\u5bb9\u3084\u98df\u4e8b\u7642\u6cd5\u304c\u5fc5\u8981\u306a\u7cd6\u5c3f\u75c5\u306a\u3069\u306b\u304a\u3044\u3066\u306f\u3001\u5f93\u6765\u3068\u7570\u306a\u3063\u305f\u540c\u8abf\u7cfb\u30b7\u30b0\u30ca\u30eb\u304c\u6709\u52b9\u3067\u3042\u308b\u3068\u3044\u3046\u3001\u30d2\u30c8\u3084\u533b\u7642\u306b\u5fdc\u7528\u3067\u304d\u308b\u767a\u898b\u3092\u6210\u3057\u9042\u3052\u307e\u3057\u305f\u3002<br \/>\n<div id=\"attachment_57006\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-57006\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/20180202_fig1-610x647.png\" alt=\"\" width=\"300\" height=\"318\" \/><p class=\"wp-caption-text\">\u56f3\uff11\u3000\u8868\u7d19\u5019\u88dc<\/p><\/div><br \/>\n\u672c\u7814\u7a76\u6210\u679c\u306f\u3001Cell Press\u30b0\u30eb\u30fc\u30d7\u3068Lancet\u30b0\u30eb\u30fc\u30d7\u304c\u5171\u540c\u904b\u55b6\u3059\u308b\u30aa\u30fc\u30d7\u30f3\u30a2\u30af\u30bb\u30b9\u8a8c\u300e<a href=\"http:\/\/dx.doi.org\/10.1016\/j.ebiom.2018.01.012\" target=\"_blank\" rel=\"noopener\">EBioMedicine<\/a>\u300f\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u306b\uff12\uff10\uff11\uff18\u5e74\uff11\u6708\uff12\uff11\u65e5\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u30012\u6708\u53f7\u306e\u8868\u7d19\u306e\u5019\u88dc\u306b\u3082\u306a\u3063\u3066\u304a\u308a\uff08\u56f3\uff11\uff09\u3001\u672c\u7814\u7a76\u5185\u5bb9\u3092\u89e3\u8aac\u3057\u305f<a href=\"http:\/\/www.ebiomedicine.com\/article\/S2352-3964(18)30024-0\/fulltext\" target=\"_blank\" rel=\"noopener\">commentary<\/a>\u3082\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4><strong>(1)<\/strong><strong>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068<\/strong><\/h4>\n<p><div id=\"attachment_57001\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-57001\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/20180202_fig2.png\" alt=\"\" width=\"300\" height=\"299\" \/><p class=\"wp-caption-text\">\u56f3\uff12\u3000\u70ad\u6c34\u5316\u7269\u3084\u9b5a\u6cb9\u306e\u03c9\u20103\u8102\u80aa\u9178\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4ecb\u3057\u3066\u6642\u8a08\u540c\u8abf\u3092\u4fc3\u9032<\/p><\/div><br \/>\n\u4f53\u5185\u6642\u8a08\u306f\u8996\u4ea4\u53c9\u4e0a\u6838\u3068\u3044\u3046\u4e3b\u6642\u8a08\u3068\u3001\u672b\u68a2\u81d3\u5668\u306b\u3042\u308b\u672b\u68a2\u6642\u8a08\u304b\u3089\u6210\u308a\u7acb\u3063\u3066\u3044\u308b\u3002\u4f53\u5185\u6642\u8a08\u306f24\u6642\u9593\u3088\u308a\u305a\u308c\u3066\u304a\u308a\u3001\u8996\u4ea4\u53c9\u4e0a\u6838\u306e\u4e3b\u6642\u8a08\u306f\u4e3b\u306b\u5916\u754c\u306e\u5149\u523a\u6fc0\u306724\u6642\u9593\u5468\u671f\u306b\u540c\u8abf\u3057\u3001\u672b\u68a2\u6642\u8a08\u306f\u98df\u4e8b\u523a\u6fc0\u3067\u540c\u8abf\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u98df\u4e8b\u306b\u3088\u308b\u540c\u8abf\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u8840\u7cd6\u4e0a\u6607\u306b\u3068\u3082\u306a\u3046\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5206\u6ccc\u3068\u305d\u306e\u5f8c\u306e\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u306b\u3088\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff08\u56f3\uff12\uff09\u3002\u3057\u304b\u3057\u306a\u304c\u30891\u578b\u7cd6\u5c3f\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3067\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306f\u8d77\u3053\u3089\u306a\u3044\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u98df\u4e8b\u6027\u306e\u540c\u8abf\u306f\u5341\u5206\u306b\u89b3\u5bdf\u3055\u308c\u308b\u3002\u3053\u306e\u3088\u3046\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u50cd\u304d\u304c\u4f4e\u4e0b\u3059\u308b2\u578b\u7cd6\u5c3f\u75c5\u3001\u3042\u308b\u3044\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5206\u6ccc\u304c\u306a\u30441\u578b\u7cd6\u5c3f\u75c5\u3067\u306f\u3001\u98df\u4e8b\u6027\u306e\u540c\u8abf\u304c\u5b9f\u969b\u3069\u306e\u3088\u3046\u306b\u884c\u308f\u308c\u3066\u3044\u308b\u304b\u3001\u8208\u5473\u304c\u3042\u308b\u70b9\u3067\u3042\u308b\u3002\u3064\u307e\u308a\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u4ecb\u3059\u308b\u540c\u8abf\u4ee5\u5916\u306e\u30b7\u30b0\u30ca\u30eb\u7cfb\u304c\u5b58\u5728\u3059\u308b\u53ef\u80fd\u6027\u304c\u5f37\u304f\u793a\u5506\u3055\u308c\u3066\u3044\u305f\u3002<\/p>\n<h4><strong>(2)<\/strong><strong>\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/strong><\/h4>\n<p><strong>\u3000<\/strong>\u6b63\u5e38\u306a\u30de\u30a6\u30b9\u306b100%\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u990c\u3092\u4e0e\u3048\u308b\u3068\u70ad\u6c34\u5316\u7269\u304c\u8c4a\u5bcc\u306a\u990c\u306b\u6bd4\u8f03\u3059\u308b\u3068\u4f5c\u7528\u306f\u5f31\u3081\u3067\u3042\u308b\u304c\u3001\u6709\u610f\u306a\u5341\u5206\u306a\u98df\u4e8b\u6027\u540c\u8abf\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002\u3053\u306e\u540c\u8abf\u6642\u306b\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u30ec\u30d9\u30eb\u306e\u4e0a\u6607\u306f\u78ba\u8a8d\u3055\u308c\u306a\u304b\u3063\u305f\u304c\u3001\u8840\u4e2d\u3084\u809d\u81d3\u3067IGF-1\uff08IGF-1: insulin-like growth factor-1; 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class=\"wp-image-57005\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2018\/02\/20180202_fig6.png\" alt=\"\" width=\"300\" height=\"271\" \/><p class=\"wp-caption-text\">\u56f3\uff16\u3000\u4eca\u56de\u306e\u7814\u7a76\u6210\u679c\u3092\u52a0\u3048\u305f\u6a21\u5f0f\u56f3<\/p><\/div><br 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Diabetes Association (ADA) \u3084 National Health Service UK (NHS UK)\u306f\u3001\u73fe\u5728 50-55 \u30b0\u30e9\u30e0\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5065\u5e38\u8005\u30fb\u7cd6\u5c3f\u75c5\u8005\u306b\u63a8\u5968\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u306f-\u7dcf\u30a8\u30cd\u30eb\u30ae\u30fc\u306e15\u201320%\u3092\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u53d6\u308b\u3053\u3068\u306b\u306a\u308a\u3001\u672c\u7814\u7a76\u306e\u6210\u679c\u3068\u3082\u5408\u81f4\u3059\u308b\u3002\u30b7\u30b9\u30c6\u30a4\u30f3\u306f\u533b\u85ac\u54c1\u3068\u3057\u3066\u3070\u304b\u308a\u3067\u306a\u304f\u3001\u5b89\u4fa1\u306a\u98df\u6750\u3068\u3057\u3066\u3082\u5229\u7528\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u30d2\u30c8\u3092\u5bfe\u8c61\u3068\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u3082\u5927\u3044\u306b\u671f\u5f85\u3067\u304d\u308b\u3002<\/p>\n<h4><strong>(5)<\/strong><strong>\u4eca\u5f8c\u306e\u8ab2\u984c<\/strong><\/h4>\n<p>\u672c\u7814\u7a76\u306f\u30de\u30a6\u30b9\u306e\u30c7\u30fc\u30bf\u3067\u3042\u308a\u3001\u3053\u306e\u6210\u679c\u3092\u3082\u3068\u306b\u30d2\u30c8\u306e\u4ecb\u5165\u8a66\u9a13\u7b49\u3092\u65e9\u3005\u306b\u9032\u3081\u3001\u30de\u30a6\u30b9\u306e\u77e5\u898b\u3092\u5b9f\u8a3c\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u307e\u305f\u30011\u578b\u306e\u307f\u306a\u3089\u305a2\u578b\u7cd6\u5c3f\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u3001\u4eca\u56de\u306e\u7814\u7a76\u7d50\u679c\u3092\u78ba\u8a8d\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u4eca\u56de\u306f\u30b7\u30b9\u30c6\u30a4\u30f3\u306e\u307f\u5019\u88dc\u3068\u3057\u305f\u304c\u3001\u30a2\u30df\u30ce\u9178\u3082\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u3063\u3066\u306f\u3001\u3088\u308a\u5f37\u529b\u306a\u4f5c\u7528\u304c\u898b\u3044\u3060\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u305d\u306e\u3088\u3046\u306a\u7814\u7a76\u3082\u9032\u3081\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n<h4><strong>(6)100<\/strong><strong>\u5b57\u7a0b\u5ea6\u306e\u6982\u8981<\/strong><\/h4>\n<p>\u672b\u68a2\u6642\u8a08\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u5229\u7528\u3057\u3066\u98df\u4e8b\u6027\u306e\u540c\u8abf\u3092\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u305f\u304c\u3001\u7cd6\u5c3f\u75c5\u306a\u3069\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb\u304c\u4f7f\u3048\u306a\u3044\u3068\u304d\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u30b7\u30b9\u30c6\u30a4\u30f3\u304c\u8c4a\u5bcc\u306a\u98df\u4e8b\u306b\u3088\u308bIGF-1\u304c\u540c\u8abf\u306b\u50cd\u304f\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002<\/p>\n<h5><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h5>\n<p>\uff08\uff11\uff09Tahara Y and Shibata S, Nat Rev Gastroenterol Hepatol. 2016<br \/>\n\uff08\uff12\uff09Vetter C and\u00a0 Scheer FA, Curr Biol. 2017<\/p>\n<h5><strong>\u8ad6\u6587\u60c5\u5831<\/strong><\/h5>\n<ul>\n<li>\u63b2\u8f09\u8a8c\uff1a\u3000EbioMedicine<\/li>\n<li>\u8ad6\u6587\u540d\uff1a<a href=\"http:\/\/dx.doi.org\/10.1016\/j.ebiom.2018.01.012\" target=\"_blank\" rel=\"noopener\">Glucagon and\/or IGF-1 production regulates resetting of the liver circadian clock in response to a protein or amino acid-only diet<\/a><\/li>\n<li>\u8457\u8005\uff1a\u3000Yuko Ikeda, Mayo Kamagata, Mizuho Hirao, Shinnosuke Yasuda, Shiho Iwami, Hiroyuki Sasaki, Miku Tsubosaka, Yuta Hattori, Ai Todoh, Konomi Tamura, Kazuto Shiga, Teiji Ohtsu and Shigenobu Shibata<\/li>\n<li>DOI: doi:10.1016\/j.ebiom.2018.01.012<\/li>\n<li>Commentary \u306e\u8a18\u4e8b\uff1a<a href=\"http:\/\/www.ebiomedicine.com\/article\/S2352-3964(18)30024-0\/fulltext\" target=\"_blank\" rel=\"noopener\">Protein-rich or amino-acid only diets entrain the liver CLOCK: time to scrap insulin? Andrea Maugeri, Jude A. Oben, Manlio Vinciguerra<\/a><\/li>\n<\/ul>\n<p>\u203b\u672c\u7814\u7a76\uff08\u306e\u4e00\u90e8\uff09\u306f\u3001\u5185\u95a3\u5e9c\u6226\u7565\u7684\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u5275\u9020\u30d7\u30ed\u30b0\u30e9\u30e0\uff08\uff33\uff29\uff30\uff09\u300c\u6b21\u4e16\u4ee3\u8fb2\u6797\u6c34\u7523\u696d\u5275\u9020\u6280\u8853\u300d\uff08\u7ba1\u7406\u6cd5\u4eba\uff1a\u751f\u7814\u652f\u63f4\u30bb\u30f3\u30bf\u30fc\uff09\u306b\u3088\u3063\u3066\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u306e\u67f4\u7530\u91cd\u4fe1\uff08\u3057\u3070\u305f\u3057\u3052\u306e\u3076\uff09\u6559\u6388\u3068\u6c60\u7530\u7950\u5b50\uff08\u3044\u3051\u3060\u3086\u3046\u3053\uff09\u4e00\u8cab\u5236\u535a\u58eb\u8ab2\u7a0b5\u5e74\u751f\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u4f53\u5185\u6642\u8a08\u306e\u98df\u4e8b\u306b\u3088\u308b\u540c\u8abf\u306b\u304a\u3044\u3066\u65b0\u898f\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002 \u4f53\u5185\u6642\u8a08\u3068\u98df\u30fb\u6804\u990a\u3068\u306e\u95a2\u4fc2\u3092\u8abf\u3079\u308b\u300c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":66483,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[145,60,178],"class_list":["post-57000","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-pressrelease","tag-health","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/57000","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=57000"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/57000\/revisions"}],"predecessor-version":[{"id":66484,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/57000\/revisions\/66484"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media\/66483"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=57000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=57000"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=57000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}