{"id":54628,"date":"2017-10-20T10:11:41","date_gmt":"2017-10-20T01:11:41","guid":{"rendered":"https:\/\/www.waseda.jp\/top\/?p=54628"},"modified":"2018-10-19T14:28:32","modified_gmt":"2018-10-19T05:28:32","slug":"%e8%85%b8%e7%ae%a1%e3%81%ab%e5%ae%9a%e7%9d%80%e3%81%99%e3%82%8b%e3%81%a8%e5%85%8d%e7%96%ab%e7%b4%b0%e8%83%9e%e3%81%ae%e9%81%8e%e5%89%b0%e3%81%aa%e6%b4%bb%e6%80%a7%e5%8c%96%e3%82%92%e5%bc%95%e3%81%8d","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/research\/news\/54628","title":{"rendered":"\u8178\u7ba1\u306b\u5b9a\u7740\u3059\u308b\u3068\u514d\u75ab\u7d30\u80de\u306e\u904e\u5270\u306a\u6d3b\u6027\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u53e3\u8154\u5e38\u5728\u83cc\u3000"},"content":{"rendered":"<h2>\u53e3\u8154\u5e38\u5728\u83cc\u306e\u4e2d\u306b\u306f\u3001 \u7570\u6240\u6027\u306b\u8178\u7ba1\u306b\u5b9a\u7740\u3059\u308b\u3068\u514d\u75ab\u3092\u6d3b\u6027\u5316\u3059\u308b\u3082\u306e\u304c\u3044\u308b<\/h2>\n<p>\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u306e<a href=\"https:\/\/researchers.waseda.jp\/profile\/ja.0aa298552ceee7f39ea1244ff5e50c84.html\" target=\"_blank\" rel=\"noopener\">\u670d\u90e8\u6b63\u5e73\u6559\u6388<\/a>\u3068\u6176\u61c9\u7fa9\u587e\u5927\u5b66\u533b\u5b66\u90e8\u306e<a href=\"http:\/\/www.med.keio.ac.jp\/research\/faculty\/22\/\" target=\"_blank\" rel=\"noopener\">\u672c\u7530\u8ce2\u4e5f\u6559\u6388<\/a>\uff08\u7406\u5316\u5b66\u7814\u7a76\u6240\u7d71\u5408\u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u6d88\u5316\u7ba1\u6052\u5e38\u6027\u7814\u7a76\u30c1\u30fc\u30e0\u30ea\u30fc\u30c0\u30fc\u517c\u4efb\uff09\u3089\u3092\u4e2d\u5fc3\u3068\u3059\u308b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u4e71\u308c\u306b\u4e57\u3058\u3066\u3001\u53e3\u8154\u306b\u5b58\u5728\u3059\u308b\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u83cc\u304c\u8178\u7ba1\u5185\u306b\u5b9a\u7740\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001TH1\u7d30\u80de<sup>\u203b\uff11<\/sup>\u3068\u547c\u3070\u308c\u308b\u514d\u75ab\u7d30\u80de\u306e\u904e\u5270\u306a\u6d3b\u6027\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u708e\u75c7\u6027\u8178\u75be\u60a3\uff08\u30af\u30ed\u30fc\u30f3\u75c5\u3084\u6f70\u760d\u6027\u5927\u8178\u708e\uff09\u306a\u3069\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u793a\u3057\u307e\u3057\u305f\uff08\u4e0b\u56f3\uff09\u3002<br \/>\n\u4eca\u56de\u306e\u6210\u679c\u306f\u3001\u7d30\u83cc\u3092\u6a19\u7684\u3068\u3057\u305f\u708e\u75c7\u6027\u75be\u60a3\u306e\u65b0\u305f\u306a\u4e88\u9632\u6cd5\u3084\u6cbb\u7642\u85ac\u3001\u8a3a\u65ad\u85ac\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<br \/>\n\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u56fd\u969b\u5b66\u8853\u96d1\u8a8c\u300eScience\u300f2017\u5e7410\u670820\u65e5\uff08\u91d1\uff09\u7248\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n\u8ad6\u6587\u540d\uff1a<a href=\"http:\/\/science.sciencemag.org\/content\/358\/6361\/359\" target=\"_blank\" rel=\"noopener\">Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation<\/a><\/p>\n<h3>\u767a\u8868\u6982\u8981<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-54629\" src=\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2017\/10\/20171019_fig1-610x419.png\" alt=\"20171019_fig1\" width=\"610\" height=\"419\" \/><\/p>\n<h3><strong>\u767a\u8868\u5185\u5bb9<\/strong><\/h3>\n<h4>1\uff0e\u80cc\u666f<\/h4>\n<p>\u6d88\u5316\u7ba1\u3084\u53e3\u8154\u306a\u3069\u306b\u306f\u591a\u69d8\u306a\u5e38\u5728\u7d30\u83cc\u304c\u5b58\u5728\u3057\u3001\u79c1\u305f\u3061\u306e\u514d\u75ab\u7cfb\u3084\u751f\u7406\u6a5f\u80fd\u306b\u5f37\u3044\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3067\u3001\u5065\u5eb7\u7dad\u6301\u306b\u5927\u304d\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u8178\u5185\u306b\u5b58\u5728\u3059\u308b\u69d8\u3005\u306a\u7d30\u83cc\u7a2e\u306e\u6570\u3084\u5272\u5408\u306e\u5909\u52d5\u304c\u708e\u75c7\u6027\u8178\u75be\u60a3\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u69d8\u3005\u306a\u75c5\u6c17\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5f37\u304f\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u3053\u306e\u3088\u3046\u306a\u8178\u5185\u7d30\u83cc\u53e2\u306e\u4e71\u308c\u304b\u3089\u75be\u60a3\u767a\u75c7\u306b\u3064\u306a\u304c\u308b\u307e\u3067\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f\u3001\u4e0d\u660e\u306a\u70b9\u304c\u591a\u304f\u6b8b\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002<br \/>\n\u305d\u3053\u3067\u3001\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u53e3\u8154\u7d30\u83cc\u304c\u708e\u75c7\u6027\u8178\u75be\u60a3\u3084\u5927\u8178\u304c\u3093\u306a\u3069\u306e\u60a3\u8005\u306e\u4fbf\u4e2d\u306b\u591a\u304f\u691c\u51fa\u3055\u308c\u308b\u3053\u3068\u306b\u6ce8\u76ee\u3057\u3001\u53e3\u8154\u7d30\u83cc\u304c\u8178\u7ba1\u5185\u306b\u5b9a\u7740\u3059\u308b\u3053\u3068\u306b\u3088\u308b\u8178\u7ba1\u514d\u75ab\u7cfb\u3078\u306e\u5f71\u97ff\u3068\u75c5\u6c17\u3068\u306e\u95a2\u308f\u308a\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n<h4>2\uff0e\u5185\u5bb9<\/h4>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u307e\u305a\u30af\u30ed\u30fc\u30f3\u75c5<sup>\u203b2<\/sup>\u60a3\u8005\u306e\u553e\u6db2\u3092\u7121\u83cc\u30de\u30a6\u30b9<sup>\u203b3<\/sup>\u306b\u7d4c\u53e3\u6295\u4e0e\u3057\u3001\u305d\u306e\u30de\u30a6\u30b9\u306e\u8178\u7ba1\u306b\u5b58\u5728\u3059\u308b\u514d\u75ab\u7d30\u80de\u306e\u7a2e\u985e\u3092\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc<sup>\u203b4<\/sup>\u306b\u3088\u308a\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u89e3\u6790\u306b\u3088\u308a\u3001\u30af\u30ed\u30fc\u30f3\u75c5\u60a3\u8005\u306e\u53e3\u8154\u306b\u5b58\u5728\u3057\u3066\u3044\u305f\u7d30\u83cc\u304c\u8178\u5185\u306b\u5b9a\u7740\u3059\u308b\u3068\u3001\u8178\u7ba1\u514d\u75ab\u7cfb\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u3042\u308b\u30af\u30ed\u30fc\u30f3\u75c5\u60a3\u8005\u306e\u553e\u6db2\u3092\u6295\u4e0e\u3057\u305f\u30de\u30a6\u30b9\u306e\u5927\u8178\u306b\u304a\u3044\u3066\u3001\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u30ac\u30f3\u30de\uff08IFN-\u03b3\uff09\u3092\u7523\u751f\u3059\u308bCD4\u967d\u6027\u306e\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\uff08TH1\u7d30\u80de<sup>\u203b1<\/sup>\uff09\u304c\u9855\u8457\u306b\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002<br \/>\n\u305d\u3053\u3067\u3001\u3053\u306e\u30af\u30ed\u30fc\u30f3\u75c5\u60a3\u8005\u306e\u553e\u6db2\u4e2d\u306e\u3069\u306e\u3088\u3046\u306a\u7d30\u83cc\u304c\u30de\u30a6\u30b9\u8178\u5185\u306b\u5b9a\u7740\u3057\u3066\u3044\u305f\u304b\u3092\u628a\u63e1\u3059\u308b\u305f\u3081\u3001\u3053\u306e\u30de\u30a6\u30b9\u306e\u7cde\u4fbf\u304b\u3089\u7d30\u83ccDNA\u3092\u62bd\u51fa\u3057\u3001\u7d30\u83cc\u7531\u6765\u306e16S rRNA\u907a\u4f1d\u5b50\u3092\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u7db2\u7f85\u7684\u306b\u8abf\u3079\u307e\u3057\u305f\u3002\u3053\u306e\u89e3\u6790\u304b\u3089\u3001\u30ca\u30a4\u30bb\u30ea\u30a2\u5c5e\u3001\u30ec\u30f3\u30b5\u7403\u83cc\u5c5e\u3001\u30b2\u30e1\u30e9\u5c5e\u3001\u30d9\u30a4\u30ed\u30cd\u30e9\u5c5e\u3001\u30d5\u30bd\u30d0\u30af\u30c6\u30ea\u30a6\u30e0\u5c5e\u3001\u30d3\u30d5\u30a3\u30c9\u30d0\u30af\u30c6\u30ea\u30a6\u30e0\u5c5e\u3001\u30a2\u30ca\u30a8\u30ed\u30b3\u30c3\u30ab\u30b9\u5c5e\u3001\u30a8\u30b7\u30a7\u30ea\u30ad\u30a2\u5c5e\uff08\u5927\u8178\u83cc\u5c5e\uff09\u3001\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u5c5e\u7d30\u83cc\u306a\u3069\u7d0430\u7a2e\u985e\u306e\u7d30\u83cc\u304c\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u3002\u6b21\u3044\u3067\u3001\u3053\u308c\u3089\u306e\u7d30\u83cc\u306e\u591a\u304f\u3092\u5358\u96e2\u30fb\u57f9\u990a\u3057\u3001\u305d\u308c\u305e\u308c\u306e\u7d30\u83cc\u3092\u7121\u83cc\u30de\u30a6\u30b9\u3078\u5b9a\u7740\u3055\u305b\u305f\u3068\u3053\u308d\u3001\u30af\u30e9\u30d6\u30b7\u30a8\u30e9\u5c5e\u306e\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u30fb\u30cb\u30e5\u30fc\u30e2\u30cb\u30a8<sup>\u203b5<\/sup>\uff08<em>Klebsiella pneumoniae<\/em>\uff09\u304cTH1\u7d30\u80de\u3092\u5f37\u304f\u8a98\u5c0e\u3059\u308b\u7d30\u83cc\u3067\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002<br \/>\n\u3055\u3089\u306b\u3001\u8178\u5185\u7d30\u83cc\u304c\u5b58\u5728\u3057\u3066\u3044\u308b\u901a\u5e38\u306eSPF<sup>\u203b6<\/sup>\uff08specific pathogen-free\uff09\u30de\u30a6\u30b9\u306b\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u30fb\u30cb\u30e5\u30fc\u30e2\u30cb\u30a8\u3092\u7d4c\u53e3\u6295\u4e0e\u3057\u3066\u3082\u8178\u7ba1\u5185\u306b\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u30fb\u30cb\u30e5\u30fc\u30e2\u30cb\u30a8\u304c\u5b9a\u7740\u3057\u5897\u6b96\u3059\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u30a2\u30f3\u30d4\u30b7\u30ea\u30f3\u7b49\u306e\u6297\u751f\u7269\u8cea\u3092\u6295\u4e0e\u3057\u305fSPF\u30de\u30a6\u30b9\u3067\u306f\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u30fb\u30cb\u30e5\u30fc\u30e2\u30cb\u30a8\u304c\u8178\u7ba1\u5185\u306b\u5b9a\u7740\u3057\u3001TH1\u7d30\u80de\u3092\u5f37\u304f\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u901a\u5e38\u6642\u306b\u306f\u5143\u3005\u3044\u308b\u8178\u5185\u7d30\u83cc\u53e2\u304c\u53e3\u8154\u304b\u3089\u5165\u3063\u3066\u304d\u305f\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u30fb\u30cb\u30e5\u30fc\u30e2\u30cb\u30a8\u306e\u8178\u7ba1\u5185\u3078\u306e\u5b9a\u7740\u3092\u963b\u6b62\u3057\u3066\u3044\u308b\u3051\u308c\u3069\u3001\u6297\u751f\u7269\u8cea\u306e\u4f7f\u7528\u306a\u3069\u306b\u3088\u308a\u8178\u5185\u7d30\u83cc\u53e2\u304c\u4e71\u308c\u308b\u3068\u3053\u306e\u5b9a\u7740\u963b\u5bb3\u52b9\u679c\u304c\u5f31\u307e\u308a\u3001\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u30fb\u30cb\u30e5\u30fc\u30e2\u30cb\u30a8\u306e\u8178\u7ba1\u5185\u3078\u306e\u5b9a\u7740\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<br \/>\n\u6b21\u306b\u3001\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u30fb\u30cb\u30e5\u30fc\u30e2\u30cb\u30a8\u306e\u8178\u7ba1\u5185\u3078\u306e\u5b9a\u7740\u304c\u30af\u30ed\u30fc\u30f3\u75c5\u306e\u767a\u75c7\u30fb\u5897\u60aa\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u306e\u304b\u3092\u8abf\u3079\u308b\u305f\u3081\u3001\u7121\u83cc\u306e\u8178\u708e\u767a\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\uff08IL-10\u6b20\u640d\u30de\u30a6\u30b9<sup>\u203b7<\/sup>\uff09\u306b\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u30fb\u30cb\u30e5\u30fc\u30e2\u30cb\u30a8\u3092\u7d4c\u53e3\u6295\u4e0e\u3057\u3001\u8178\u7ba1\u708e\u75c7\u306e\u72b6\u614b\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u6bd4\u8f03\u5bfe\u8c61\u3068\u3057\u3066\u5927\u8178\u83cc\u3092\u6295\u4e0e\u3057\u305fIL-10\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u8178\u7ba1\u306b\u708e\u75c7\u304c\u8d77\u3053\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u30fb\u30cb\u30e5\u30fc\u30e2\u30cb\u30a8\u3092\u6295\u4e0e\u3057\u305fIL-10\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u5f37\u3044\u8178\u7ba1\u708e\u75c7\u304c\u8d77\u3053\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u4e00\u65b9\u3067\u91ce\u751f\u578b\u30de\u30a6\u30b9\u306b\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u30fb\u30cb\u30e5\u30fc\u30e2\u30cb\u30a8\u3092\u7d4c\u53e3\u6295\u4e0e\u3057\u3066\u3082\u3001\u8178\u7ba1\u3067\u306eTH1\u7d30\u80de\u306e\u5897\u52a0\u306f\u898b\u3089\u308c\u308b\u3082\u306e\u306e\u708e\u75c7\u306f\u8d77\u3053\u308a\u307e\u305b\u3093\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u30fb\u30cb\u30e5\u30fc\u30e2\u30cb\u30a8\u306e\u8178\u7ba1\u5185\u3078\u306e\u5b9a\u7740\u304cTH1\u7d30\u80de\u306e\u904e\u5270\u306a\u5897\u6b96\u3084\u6d3b\u6027\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u5bbf\u4e3b\u306e\u907a\u4f1d\u578b\u306b\u3088\u3063\u3066\u306f\u708e\u75c7\u306e\u60f9\u8d77\u30fb\u5897\u60aa\u30fb\u9077\u5ef6\u5316\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u6f70\u760d\u6027\u5927\u8178\u708e\u306e\u60a3\u8005\u306e\u553e\u6db2\u3092\u7121\u83cc\u30de\u30a6\u30b9\u306b\u6295\u4e0e\u3059\u308b\u5b9f\u9a13\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u4e00\u90e8\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u30af\u30ed\u30fc\u30f3\u75c5\u60a3\u8005\u306e\u553e\u6db2\u6295\u4e0e\u30de\u30a6\u30b9\u3068\u540c\u69d8\u306b\u8178\u7ba1\u3067\u306e\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u5c5e\u83cc\u306e\u5b9a\u7740\u3068TH1\u7d30\u80de\u306e\u5897\u52a0\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u5065\u5e38\u8005\u306e\u553e\u6db2\u3092\u7528\u3044\u305f\u5b9f\u9a13\u306b\u304a\u3044\u3066\u3082\u3001\u8178\u7ba1\u3067\u306e\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u30fb\u30cb\u30e5\u30fc\u30e2\u30cb\u30a8\u306e\u5b9a\u7740\u3068TH1\u7d30\u80de\u306e\u5897\u52a0\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001TH1\u7d30\u80de\u3092\u8a98\u5c0e\u3059\u308b\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u5c5e\u83cc\u306f\u708e\u75c7\u6027\u8178\u75be\u60a3\u60a3\u8005\u3060\u3051\u3067\u306a\u304f\u5065\u5e38\u8005\u306e\u53e3\u8154\u306b\u3082\u5b58\u5728\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u305f\u3081\u3001\u4f8b\u3048\u3070\u9577\u671f\u7684\u306b\u904e\u5270\u91cf\u306e\u6297\u751f\u7269\u8cea\u3092\u670d\u7528\u3057\u305f\u5834\u5408\u306b\u306f\u5065\u5e38\u8005\u3067\u3082\u8178\u7ba1\u3078\u306e\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u5c5e\u83cc\u306e\u5b9a\u7740\u304c\u8d77\u3053\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u904e\u5ea6\u306a\u6297\u751f\u7269\u8cea\u306e\u670d\u7528\u306b\u306f\u6c17\u3092\u4ed8\u3051\u308b\u3079\u304d\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<h4>\uff13\uff0e\u4eca\u5f8c\u306e\u5c55\u958b<\/h4>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u30af\u30ed\u30fc\u30f3\u75c5\u3084\u6f70\u760d\u6027\u5927\u8178\u708e\u306a\u3069\u306e\u6162\u6027\u708e\u75c7\u6027\u8178\u75be\u60a3\u306e\u767a\u75c7\u306b\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u5c5e\u7d30\u83cc\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u5c5e\u7d30\u83cc\u304c\u6162\u6027\u708e\u75c7\u6027\u8178\u75be\u60a3\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u5275\u85ac\u6a19\u7684\u3068\u306a\u308a\u5f97\u307e\u3059\u3002\u4eca\u5f8c\u306f\u3001\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u5c5e\u7d30\u83cc\u3092\u9078\u629e\u7684\u306b\u6392\u9664\u30fb\u6bba\u83cc\u3059\u308b\u6297\u751f\u7269\u8cea\u306a\u3069\u306e\u958b\u767a\u3084\u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u5c5e\u7d30\u83cc\u304c\u8178\u7ba1\u5185\u306b\u5b9a\u7740\u3055\u305b\u306a\u3044\u3088\u3046\u306a\u85ac\u5264\u306e\u958b\u767a\u3092\u901a\u3057\u3066\u3001\u3053\u308c\u3089\u75be\u60a3\u306e\u4e88\u9632\u6cd5\u3084\u6cbb\u7642\u85ac\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h4>\uff14\uff0e\u7279\u8a18\u4e8b\u9805<\/h4>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u306e\u4e00\u90e8\u306f\u3001\u4e0b\u8a18\u306b\u793a\u3059\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb\u306e\u9769\u65b0\u7684\u5148\u7aef\u7814\u7a76\u958b\u767a\u652f\u63f4\u4e8b\u696d\uff08AMED-CREST\u304a\u3088\u3073LEAP\uff09\u306b\u304a\u3051\u308b\u7814\u7a76\u958b\u767a\u306e\u4e00\u74b0\u3068\u3057\u3066\u884c\u308f\u308c\u307e\u3057\u305f\u3002<br \/>\n<strong>\uff11\uff09AMED-CREST<\/strong><\/p>\n<ul>\n<li>\u7814\u7a76\u958b\u767a\u9818\u57df\uff1a\u300c\u751f\u4f53\u6052\u5e38\u6027\u7dad\u6301\u30fb\u5909\u5bb9\u7834\u7dbb\u6a5f\u69cb\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u7684\u7406\u89e3\u306b\u57fa\u3065\u304f\u6700\u9069\u533b\u7642\u5b9f\u73fe\u306e\u305f\u3081\u306e\u6280\u8853\u5275\u51fa\u300d\uff08\u7814\u7a76\u958b\u767a\u7dcf\u62ec\uff1a\u6c38\u4e95\u826f\u4e09\uff09<\/li>\n<li>\u7814\u7a76\u958b\u767a\u8ab2\u984c\u540d\uff1a\u300c<a href=\"https:\/\/www.jst.go.jp\/kisoken\/crest\/project\/37\/37_03.html\" target=\"_blank\" rel=\"noopener\">\u8178\u5185\u5e38\u5728\u7d30\u83cc\u7279\u6027\u7406\u89e3\u306b\u57fa\u3065\u304f\u96e3\u6cbb\u6027\u75be\u60a3\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u958b\u767a<\/a>\u300d<\/li>\n<li>\u7814\u7a76\u958b\u767a\u4ee3\u8868\u8005\uff1a\u672c\u7530\u8ce2\u4e5f<\/li>\n<li>\u5b9f\u65bd\u671f\u9593\uff1a\u5e73\u621024\u5e74\u5ea6\u304b\u3089\u5e73\u621028\u5e74\u5ea6<\/li>\n<\/ul>\n<p>\u203b\u672c\u7814\u7a76\u958b\u767a\u9818\u57df\u306f\u3001\u5e73\u621027\u5e74\uff14\u6708\u306e\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb\u306e\u767a\u8db3\u306b\u4f34\u3044\u3001\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb\uff08JST\uff09\u3088\u308a\u79fb\u7ba1\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n<strong>\uff12\uff09LEAP\uff08\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u30bf\u30a4\u30d7\uff09<\/strong><\/p>\n<ul>\n<li>\u7814\u7a76\u958b\u767a\u8ab2\u984c\u540d\uff1a\u300c\u8178\u5185\u7d30\u83cc\u682a\u30ab\u30af\u30c6\u30eb\u3092\u7528\u3044\u305f\u65b0\u898f\u533b\u85ac\u54c1\u306e\u5275\u51fa\u300d<\/li>\n<li>\u7814\u7a76\u958b\u767a\u4ee3\u8868\u8005\uff1a\u672c\u7530\u8ce2\u4e5f<\/li>\n<li>\u5b9f\u65bd\u671f\u9593\uff1a\u5e73\u621028\u5e74\u5ea6\u304b\u3089\u5e73\u621032\u5e74\u5ea6<\/li>\n<\/ul>\n<h4>\uff15\uff0e\u8ad6\u6587<\/h4>\n<ul>\n<li>\u30bf\u30a4\u30c8\u30eb\uff1a\u201c<a href=\"http:\/\/science.sciencemag.org\/content\/358\/6361\/359\" target=\"_blank\" rel=\"noopener\">Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation<\/a>\u201d(\u53e3\u8154\u7531\u6765\u7d30\u83cc\u306e\u8178\u7ba1\u5185\u5b9a\u7740\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308bTH1\u7d30\u80de\u3068\u708e\u75c7\u8a98\u5c0e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e)<\/li>\n<li>\u8457\u8005\u540d\uff1a\u65b0\u5e78\u4e8c\u3001\u9808\u7530\u4e99\u3001Chengwei Luo\u3001\u6cb3\u53e3\u8cb4\u662d\u3001\u5143\u5c3e\u4f0a\u7e54\u3001\u6210\u5cf6\u8056\u5b50\u3001\u6728\u53e3\u60a0\u4e5f\u3001\u5b89\u9593\u6075\u5b50\u3001\u6e21\u8fba\u6804\u4e00\u90ce\u3001\u7530\u4e4b\u4e0a\u5927\u3001Christoph A. Thaiss\u3001\u4f50\u85e4\u7e6d\u5b50\u3001\u8c4a\u5ca1\u516c\u5fb3\u3001Heba S. Said\u3001\u5c71\u4e0a\u535a\u4e00\u3001Scott A. Rice\u3001Dirk Gevers\u3001Ryan C. Johnson\u3001Julia A. Segre\u3001Kong Chen\u3001Jay K. Kolls\u3001Eran Elinav\u3001\u68ee\u7530\u82f1\u5229\u3001Ramnik J. Xavier\u3001\u670d\u90e8\u6b63\u5e73\u3001\u672c\u7530\u8ce2\u4e5f<\/li>\n<li>\u63b2\u8f09\u8a8c\uff1a\u300e Science\u300f\u30002017\u5e7410\u670820\u65e5\u30aa\u30f3\u30e9\u30a4\u30f3\u7248<\/li>\n<\/ul>\n<h5>\u7528\u8a9e\u89e3\u8aac<\/h5>\n<ul>\n<li>\u203b1\u00a0\u00a0\u00a0 TH1\u7d30\u80de<\/li>\n<\/ul>\n<p>CD4\u967d\u6027\u306e\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\u306e\u4e00\u7a2e\u3067\u3001\u4e3b\u306b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u30ac\u30f3\u30de\uff08IFN-\u03b3\uff09\u3092\u7523\u751f\u3057\u307e\u3059\u3002IFN-\u03b3\u306f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3092\u6d3b\u6027\u5316\u3057\u3001\u305d\u306e\u6bba\u83cc\u4f5c\u7528\u3092\u5f37\u5316\u3057\u307e\u3059\u3002\u4e3b\u306b\u7d30\u80de\u5185\u5bc4\u751f\u7d30\u83cc\u306e\u611f\u67d3\u9632\u5fa1\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u904e\u5270\u306a\u6d3b\u6027\u5316\u306f\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u767a\u75c7\u306b\u3064\u306a\u304c\u308b\u305f\u3081\u9069\u5207\u306a\u5236\u5fa1\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<ul>\n<li>\u203b2\u00a0\u00a0\u00a0 \u30af\u30ed\u30fc\u30f3\u75c5<\/li>\n<\/ul>\n<p>\u53e3\u304b\u3089\u809b\u9580\u306b\u3044\u305f\u308b\u6d88\u5316\u7ba1\u306b\u975e\u9023\u7d9a\u6027\u306b\u708e\u75c7\u30fb\u6f70\u760d\u304c\u3067\u304d\u308b\u75c5\u6c17\u3002\u56de\u8178\u306e\u672b\u7aef\u306b\u3082\u3063\u3068\u3082\u597d\u767a\u3057\u307e\u3059\u3002\u6d3b\u52d5\u671f\u3068\u5bdb\u89e3\u671f\u3092\u7e70\u308a\u8fd4\u3057\u3001\u305d\u306e\u904e\u7a0b\u3067\u8178\u304c\u72ed\u304f\u306a\u308a\u72ed\u7a84\u3092\u8d77\u3053\u3057\u3001\u8178\u9589\u585e\u3092\u8d77\u3053\u3059\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u307e\u3060\u75c5\u56e0\u306f\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u907a\u4f1d\u7684\u306a\u7d20\u56e0\u3001\u514d\u75ab\u7cfb\u306e\u7570\u5e38\u3001\u8178\u5185\u7d30\u83cc\u3084\u98df\u4e8b\u306a\u3069\u306e\u74b0\u5883\u8981\u56e0\u304c\u8907\u5408\u7684\u306b\u7d44\u307f\u5408\u308f\u3055\u3063\u3066\u8d77\u3053\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<ul>\n<li>\u203b3\u00a0\u00a0\u00a0 \u7121\u83cc\u30de\u30a6\u30b9<\/li>\n<\/ul>\n<p>\u7121\u83cc\u72b6\u614b\u3067\u98fc\u80b2\u3067\u304d\u308b\u7279\u6b8a\u306a\u74b0\u5883\uff08\u30a2\u30a4\u30bd\u30ec\u30fc\u30bf\u30fc\uff09\u5185\u3067\u98fc\u80b2\u3057\u305f\u30de\u30a6\u30b9\u3067\u3001\u8178\u5185\u7d30\u83cc\u3084\u76ae\u819a\u306a\u3069\u306e\u5e38\u5728\u7d30\u83cc\u3092\u542b\u3081\u3001\u691c\u51fa\u53ef\u80fd\u306a\u5fae\u751f\u7269\u3092\u307e\u3063\u305f\u304f\u6301\u305f\u306a\u3044\u30de\u30a6\u30b9\u3002\u5e38\u5728\u7d30\u83cc\u3092\u3082\u305f\u306a\u3044\u305f\u3081\u3001\u751f\u7406\u5b66\u7684\u3001\u514d\u75ab\u5b66\u7684\u306b\u3044\u304f\u3064\u304b\u306e\u7570\u5e38\u304c\u307f\u3089\u308c\u307e\u3059\u304c\u3001\u5065\u5eb7\u306a\u72b6\u614b\u3092\u7dad\u6301\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<ul>\n<li>\u203b4\u00a0\u00a0\u00a0 \u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc<\/li>\n<\/ul>\n<p>\u4e00\u3064\u306e\u7d30\u80de\u306e\u8907\u6570\u306e\u5206\u5b50\uff08\u4e3b\u306b\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u3092\u540c\u6642\u304b\u3064\u9ad8\u901f\u306b\u6e2c\u5b9a\u3057\u3001\u8907\u6570\u7a2e\u985e\u306e\u7d30\u80de\u306e\u5206\u5e03\u3092\u89e3\u6790\u3059\u308b\u88c5\u7f6e\u3002\u7d30\u80de\u8868\u9762\u307e\u305f\u306f\u5185\u90e8\u306e\u5206\u5b50\u3092\u86cd\u5149\u7269\u8cea\u3067\u6a19\u8b58\u3057\u305f\u5f8c\u3001\u7d30\u80de\u4e00\u3064\u305a\u3064\u306b\u4e00\u5b9a\u6ce2\u9577\u306e\u30ec\u30fc\u30b6\u30fc\u5149\u3092\u5f53\u3066\u305f\u6642\u306b\u751f\u3058\u308b\u86cd\u5149\u6ce2\u9577\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u305d\u306e\u7d30\u80de\u304c\u4f55\u306e\u5206\u5b50\u3092\u6301\u3063\u3066\u3044\u308b\u304b\u3092\u5206\u6790\u3057\u307e\u3059\u3002\u3042\u308b\u90e8\u4f4d\u306b\u5b58\u5728\u3059\u308b\u7d30\u80de\u96c6\u56e3\u306e\u5897\u6e1b\u3084\u6a5f\u80fd\u5206\u5b50\u306e\u767a\u73fe\u91cf\u306e\u5897\u6e1b\u3092\u89e3\u6790\u3059\u308b\u305f\u3081\u306b\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<ul>\n<li>\u203b5\u00a0\u00a0\u00a0 \u30af\u30ec\u30d6\u30b7\u30a8\u30e9\u30fb\u30cb\u30e5\u30fc\u30e2\u30cb\u30a8\uff08<em>Klebsiella pneumoniae<\/em>\uff09<\/li>\n<\/ul>\n<p>\u30b0\u30e9\u30e0\u9670\u6027\u306e\u687f\u83cc\u3067\u3001\u80ba\u708e\u687f\u83cc\u3068\u3082\u547c\u3070\u308c\u307e\u3059\u3002\u30d2\u30c8\u306e\u53e3\u8154\u3084\u8178\u5185\u306b\u5e38\u5728\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u901a\u5e38\u306f\u75c5\u6c17\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u514d\u75ab\u7cfb\u304c\u5f31\u3063\u3066\u3044\u308b\u4eba\u3084\u9ad8\u9f62\u8005\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u306a\u3069\u3067\u306f\u3001\u80ba\u708e\u3084\u6c17\u7ba1\u652f\u708e\u3001\u8180\u80f1\u708e\u306a\u3069\u65e5\u548c\u898b\u611f\u67d3\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<ul>\n<li>\u203b6\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 SPF\u30de\u30a6\u30b9<\/li>\n<\/ul>\n<p>\u7814\u7a76\u3067\u7528\u3044\u3089\u308c\u308b\u30de\u30a6\u30b9\u98fc\u80b2\u65bd\u8a2d\u306e\u57fa\u6e96\u3092\u6e80\u305f\u3057\u305f\u6e05\u6f54\u306a\u74b0\u5883\u3067\u98fc\u80b2\u3055\u308c\u3001\u75c5\u6c17\u3092\u5f15\u304d\u8d77\u3053\u3059\u75c5\u539f\u4f53\uff08specific pathogen\uff09\u304c\u3044\u306a\u3044\uff08free\uff09\u30de\u30a6\u30b9\u3002\u8178\u5185\u3084\u76ae\u819a\u306b\u306f\u5e38\u5728\u7d30\u83cc\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<ul>\n<li>\u203b7\u00a0\u00a0\u00a0 IL-10\u6b20\u640d\u30de\u30a6\u30b9<\/li>\n<\/ul>\n<p>\u514d\u75ab\u7cfb\u3092\u6291\u5236\u3059\u308b\u6a5f\u80fd\u3092\u3082\u3064\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\uff08IL\uff09-10\u3092\u907a\u4f1d\u7684\u306b\u50cd\u3051\u306a\u304f\u3057\u305f\u30de\u30a6\u30b9\u3002\u3053\u306e\u30de\u30a6\u30b9\u3067\u306f\u514d\u75ab\u7cfb\u306e\u6291\u5236\u304c\u4e0d\u5341\u5206\u306a\u305f\u3081\u3001SPF\u74b0\u5883\u3067\u98fc\u80b2\u3059\u308b\u3068\u81ea\u7136\u306b\u8178\u708e\u3092\u767a\u75c7\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u7121\u83cc\u74b0\u5883\u3067\u98fc\u80b2\u3059\u308b\u3068\u8178\u708e\u306e\u767a\u75c7\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u3001IL-10\u6b20\u640d\u30de\u30a6\u30b9\u306e\u8178\u708e\u306e\u767a\u75c7\u306b\u306f\u8178\u5185\u7d30\u83cc\u306e\u5b58\u5728\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3069\u306e\u3088\u3046\u306a\u7d30\u83cc\u7a2e\u304c\u708e\u75c7\u60f9\u8d77\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u304b\u306f\u3053\u308c\u307e\u3067\u3042\u307e\u308a\u3088\u304f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<h5>\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7<\/h5>\n<ul>\n<li>\u6176\u61c9\u7fa9\u587e\u5927\u5b66\u533b\u5b66\u90e8\uff08\u672c\u7530\u8ce2\u4e5f\u3001\u65b0\u5e78\u4e8c\u3001\u9808\u7530\u4e99\u3001\u6cb3\u53e3\u8cb4\u662d\u3001\u5b89\u9593\u6075\u5b50\u3001\u7530\u4e4b\u4e0a\u5927\uff09<\/li>\n<li>\u7406\u5316\u5b66\u7814\u7a76\u6240\u7d71\u5408\u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff08\u672c\u7530\u8ce2\u4e5f\u3001\u65b0\u5e78\u4e8c\u3001\u6cb3\u53e3\u8cb4\u662d\u3001\u5143\u5c3e\u4f0a\u7e54\u3001\u6210\u5cf6\u8056\u5b50\u3001\u6e21\u8fba\u6804\u4e00\u90ce\u3001\u7530\u4e4b\u4e0a\u5927\uff09<\/li>\n<li>\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u65b0\u9818\u57df\u5275\u6210\u79d1\u5b66\u7814\u7a76\u79d1\uff08\u670d\u90e8\u6b63\u5e73\u3001\u9808\u7530\u4e99\u3001\u6728\u53e3\u60a0\u4e5f\uff09<\/li>\n<li>\u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u5148\u9032\u7406\u5de5\u5b66\u7814\u7a76\u79d1\uff08\u670d\u90e8\u6b63\u5e73\u3001\u9808\u7530\u4e99\u3001Heba S. Said\uff09<\/li>\n<li>\u7406\u5316\u5b66\u7814\u7a76\u6240\u74b0\u5883\u8cc7\u6e90\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff08\u4f50\u85e4\u7e6d\u5b50\u3001\u8c4a\u5ca1\u516c\u5fb3\uff09<\/li>\n<li>\u5927\u962a\u5e02\u7acb\u5927\u5b66\u533b\u5b66\u90e8\uff08\u5c71\u4e0a\u535a\u4e00\uff09<\/li>\n<li>\u5ca1\u5c71\u5927\u5b66\u8fb2\u5b66\u90e8\uff08\u68ee\u7530\u82f1\u5229\uff09<\/li>\n<li>\u7c73\u56fdBroad Institute of MIT and Harvard\uff08Chengwei Luo\u3001Dirk Gevers\u3001Ramnik J. Xavier\uff09<\/li>\n<li>\u30a4\u30b9\u30e9\u30a8\u30ebWeizmann Institute of Science\uff08Christoph A. Thaiss\u3001Eran Elinav\uff09<\/li>\n<li>\u30b7\u30f3\u30ac\u30dd\u30fc\u30ebSingapore Centre on Environmental Life Sciences Engineering\uff08Scott A. Rice\uff09<\/li>\n<li>\u7c73\u56fdNIH National Human Genome Research Institute\uff08Ryan C. Johnson\u3001Julia A. Segre\uff09<\/li>\n<li>\u7c73\u56fdUniversity of Pittsburgh School of Medicine\uff08Kong Chen\u3001Jay K. Kolls\uff09<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u53e3\u8154\u5e38\u5728\u83cc\u306e\u4e2d\u306b\u306f\u3001 \u7570\u6240\u6027\u306b\u8178\u7ba1\u306b\u5b9a\u7740\u3059\u308b\u3068\u514d\u75ab\u3092\u6d3b\u6027\u5316\u3059\u308b\u3082\u306e\u304c\u3044\u308b \u65e9\u7a32\u7530\u5927\u5b66\u7406\u5de5\u5b66\u8853\u9662\u306e\u670d\u90e8\u6b63\u5e73\u6559\u6388\u3068\u6176\u61c9\u7fa9\u587e\u5927\u5b66\u533b\u5b66\u90e8\u306e\u672c\u7530\u8ce2\u4e5f\u6559\u6388\uff08\u7406\u5316\u5b66\u7814\u7a76\u6240\u7d71\u5408\u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u6d88\u5316\u7ba1\u6052\u5e38\u6027\u7814\u7a76\u30c1\u30fc\u30e0\u30ea\u30fc\u30c0\u30fc\u517c\u4efb\uff09\u3089 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":66739,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[145,178],"class_list":["post-54628","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-pressrelease","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/54628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/comments?post=54628"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/54628\/revisions"}],"predecessor-version":[{"id":66740,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/posts\/54628\/revisions\/66740"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media\/66739"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/media?parent=54628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/categories?post=54628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/research\/wp-json\/wp\/v2\/tags?post=54628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}