\n
![\"20170509_fig1\"](\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2017\/05\/20170509_fig1-610x537.png\")
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\n\u672c\u7814\u7a76\u306f\u3001\u6750\u6599\u5316\u5b66\u3001\u7269\u7406\u5b66\u3001\u751f\u7269\u5b66\u306e\u8907\u6570\u306e\u5c02\u9580\u5206\u91ce\u306e\u77e5\u6075\u3092\u7d50\u96c6\u3057\u3001\u6700\u7d42\u7684\u306b\u65e5\u672c\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u3001\u305d\u3057\u3066\u7c73\u56fd\u3078\u3068\u3001\u5206\u91ce\u3082\u56fd\u5883\u3082\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306b\u6a2a\u65ad\u3057\u305f\u5b66\u969b\u7684\u306a\u7814\u7a76\u3068\u3057\u3066\u306e\u6210\u679c\u3067\u3059\u3002
\n\u4eca\u56de\u306e\u7814\u7a76\u6210\u679c\u306f\u3001\u82f1\u56fdNature Publishing Group\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u79d1\u5b66\u96d1\u8a8c\u300eScientific Reports<\/a>\u300f\u306b2017\u5e74\uff15\u6708\uff13\u65e5\uff08\u73fe\u5730\u6642\u9593\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n
(1)<\/strong>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u3053\u3068<\/strong><\/h4>\n\u73fe\u5728\u3001\u5148\u9032\u56fd\u3084\u767a\u5c55\u9014\u4e0a\u56fd\u306b\u95a2\u308f\u3089\u305a\u3001\u80a5\u6e80\u306e\u5897\u52a0\u304c\u5927\u304d\u306a\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u7cd6\u5c3f\u75c5\u3001\u5fc3\u75be\u60a3\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u591a\u304f\u306e\u75c5\u6c17\u306e\u4e00\u56e0\u3068\u306a\u308b\u304b\u3089\u3067\u3059\u3002\u80a5\u6e80\u306f\u3001\u79c1\u305f\u3061\u304c\u98df\u4e8b\u304b\u3089\u6442\u53d6\u3059\u308b\u30ab\u30ed\u30ea\u30fc\u306e\u91cf\u304c\u3001\u79c1\u305f\u3061\u304c\u751f\u304d\u308b\u306e\u306b\u4f7f\u308f\u308c\u308b\u6d88\u8cbb\u30ab\u30ed\u30ea\u30fc\u306e\u91cf\u3092\u4e0a\u56de\u308b\u3053\u3068\u3067\u751f\u3058\u307e\u3059\u3002\u5f93\u3063\u3066\u3001\u300c\u80a5\u6e80\u306e\u5bfe\u7b56\u306b\u306f\u30ab\u30ed\u30ea\u30fc\u6442\u53d6\u91cf\u3092\u6e1b\u3089\u3059\u3053\u3068\u304c\u6709\u52b9\u3067\u3042\u308b\u300d\u3068\u4e00\u5fdc\u306f\u8a00\u3048\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u79c1\u305f\u3061\u306e\u4f53\u306f\u5143\u6765\u3001\u98e2\u9913\u304b\u3089\u8eab\u3092\u5b88\u308b\u305f\u3081\u306b\u30ab\u30ed\u30ea\u30fc\u3092\u8102\u80aa\u3068\u3057\u3066\u8caf\u3081\u3053\u307f\u6613\u3044\u6027\u8cea\u3092\u6301\u3064\u3053\u3068\u3001\u307e\u305f\u30ab\u30ed\u30ea\u30fc\u6442\u53d6\u3092\u6e1b\u3089\u3057\u305f\u72b6\u614b\u3078\u4f53\u304c\u4e00\u5ea6\u9069\u5fdc\u3059\u308b\u3068\u3001\u305d\u3053\u304b\u3089\u306e\u4f53\u91cd\u6e1b\u5c11\u304c\u6975\u3081\u3066\u96e3\u3057\u304f\u306a\u308b\u306a\u3069\u3001\u539f\u7406\u7684\u306b\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u306f\u9650\u754c\u304c\u3042\u308b\u3053\u3068\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u53c2\u8003\u6587\u732e\uff11\uff09\u3002
\n\u3044\u3063\u307d\u3046\u3067\u3001\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u3001\u6442\u53d6\u91cf\u3067\u306f\u306a\u304f\u6d88\u8cbb\u91cf\u306b\u7740\u76ee\u3057\u3001\u7372\u5f97\u3057\u305f\u30ab\u30ed\u30ea\u30fc\u3092\u71b1\u3068\u3057\u3066\u6d88\u8cbb\u3059\u308b\u300c\u7d30\u80de\u306e\u71b1\u7523\u751f\u300d\u3092\u4fc3\u9032\u3059\u308b\u85ac\u306e\u958b\u767a\u304c\u7cbe\u529b\u7684\u306b\u884c\u308f\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306e\u4f53\u306e\u4e2d\u3067\u71b1\u7523\u751f\u3092\u7a4d\u6975\u7684\u306b\u884c\u3063\u3066\u3044\u308b\u306e\u304c\u3001\u8910\u8272\u8102\u80aa\u7d30\u80de\u3068\u7b4b\u8089\u306e\u7d30\u80de\u3067\u3059\u3002\u7279\u306b\u8910\u8272\u8102\u80aa\u7d30\u80de\u306f\u3001\u4eca\u307e\u3067\u5c0f\u578b\u3052\u3063\u6b6f\u985e\u3084\u30d2\u30c8\u4e73\u5e7c\u5150\u3067\u306e\u7814\u7a76\u304c\u76db\u3093\u3067\u3057\u305f\u304c\u3001\u30d2\u30c8\u6210\u4eba\u3067\u3082\u305d\u306e\u91cd\u8981\u6027\u304c\u518d\u8a8d\u8b58\u3055\u308c\u3001\u8fd1\u5e74\u3001\u6cbb\u7642\u85ac\u306e\u6a19\u7684\u3068\u3057\u3066\u3082\u5927\u304d\u306a\u6ce8\u76ee\u3092\u96c6\u3081\u59cb\u3081\u3066\u3044\u307e\u3059\u3002
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\n\u305d\u3053\u3067\u3001\u8910\u8272\u8102\u80aa\u7d30\u80de\u304b\u3089\u751f\u307e\u308c\u305f\u71b1\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u7d30\u80de\u306e\u6e29\u5ea6\u5909\u5316\u3092\u3001\u86cd\u5149\u30b7\u30b0\u30ca\u30eb\u306e\u5909\u5316\u3068\u3057\u3066\u8aad\u307f\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u3001\u7d30\u80de\u7528\u306e\u300c\u86cd\u5149\u6e29\u5ea6\u8a08\u300d\u3092\u7528\u3044\u305f\u6280\u8853\u306e\u958b\u767a\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u65b0\u4e95\u7814\u7a76\u9662\u8b1b\u5e2b\u3089\uff08\u53c2\u8003\u6587\u732e\uff12\uff09\u306e\u4ed6\u306b\u3082\u3001\u4eac\u90fd\u5927\u5b66\u3084\u5927\u962a\u5927\u5b66\u306e\u30c1\u30fc\u30e0\u304c\u907a\u4f1d\u5b50\u5de5\u5b66\u7684\u306a\u624b\u6cd5\uff08\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u3092\u3001\u6771\u4eac\u5927\u5b66\u306e\u30c1\u30fc\u30e0\u304c\u30ca\u30ce\u30b2\u30eb\u7c92\u5b50\u3092\u7528\u3044\u305f\u65b9\u6cd5\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u5927\u91cf\u306b\u5b58\u5728\u3059\u308b\u8910\u8272\u7d30\u80de\u306b\u5bfe\u3057\u3066\u3001\u86cd\u5149\u6e29\u5ea6\u8a08\u3092\u5747\u4e00\u3001\u7c21\u5358\u306b\u5c0e\u5165\u3057\u3066\u3001\u3057\u304b\u3082\u9577\u6642\u9593\u306b\u308f\u305f\u3063\u3066\u5b89\u5b9a\u3057\u3066\u6e29\u5ea6\u5909\u5316\u3092\u691c\u51fa\u3059\u308b\u65b9\u6cd5\u304c\u3053\u308c\u307e\u3067\u306b\u7121\u304b\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u85ac\u5264\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u6307\u6a19\u3068\u3057\u3066\u6e29\u5ea6\u5909\u5316\u3092\u6271\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n
(2)<\/strong>\u4eca\u56de\u306e\u7814\u7a76\u3067\u65b0\u305f\u306b\u5b9f\u73fe\u3057\u3088\u3046\u3068\u3057\u305f\u3053\u3068\u3001\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068<\/strong><\/h4>\n\u4eca\u56de\u3001\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u8910\u8272\u8102\u80aa\u7d30\u80de\u304b\u3089\u306e\u71b1\u7523\u751f\u3092\u3001\u5149\u5b66\u9855\u5fae\u93e1\u4e0b\u30671\u7d30\u80de\u3054\u3068\u306b\u86cd\u5149\u6e29\u5ea6\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3057\u3066\u691c\u51fa\u3059\u308b\u65b0\u3057\u3044\u624b\u6cd5\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u86cd\u5149\u6e29\u5ea6\u8a08\u3092\u3001\u30de\u30a6\u30b9\u7531\u6765\u306e\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001\u30d2\u30c8\u7531\u6765\u306e\u7d30\u80de\u304b\u3089\u5206\u5316\u8a98\u5c0e\u3057\u305f\u8910\u8272\u8102\u80aa\u7d30\u80de\u306b\u5c0e\u5165\u3057\u3001\u5149\u5b66\u9855\u5fae\u93e1\u3067\u89b3\u5bdf\u3057\u306a\u304c\u3089\u3001\u8996\u91ce\u5185\u306b\u3042\u308b\u591a\u6570\u306e\u7d30\u80de\u304c\u500b\u5225\u306b\u71b1\u7523\u751f\u3057\u3066\u6e29\u5ea6\u5909\u5316\u3059\u308b\u69d8\u5b50\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u898b\u308b\u3053\u3068\u306b\u3001\u521d\u3081\u3066\u6210\u529f\u3057\u307e\u3057\u305f\u3002
\n
![\"\u5de6\u304b\u3089R\u00f3kus](\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2017\/05\/20170509_fig2.png\")
\u5de6\u304b\u3089R\u00f3kus Kriszt\u6c0f\u3001Michael Raghunath\u535a\u58eb\u3001\u65b0\u4e95\u654f\u535a\u58eb<\/p><\/div><\/p>\n
(3)<\/strong>\u305d\u306e\u305f\u3081\u306b\u65b0\u3057\u304f\u958b\u767a\u3057\u305f\u624b\u6cd5<\/strong><\/h4>\n\u8910\u8272\u8102\u80aa\u7d30\u80de\u3067\u306e\u8a08\u6e2c\u306b\u3068\u3063\u3066\u3001\u3088\u308a\u9069\u3057\u305f\u5316\u5b66\u7684\u306a\u7279\u6027\u3092\u6301\u305f\u305b\u308b\u305f\u3081\u306b\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u56fd\u7acb\u5927\u5b66\u306eYoung-Tae Chang\u6559\u6388\u3089\u304c\u3001\u4eca\u307e\u3067\u306b\u5171\u540c\u3067\u958b\u767a\u3057\u3066\u3044\u305f\u86cd\u5149\u6e29\u5ea6\u8a08\uff08ER thermo yellow\uff1a\u53c2\u8003\u6587\u732e2\uff09\u306b\u6539\u826f\u3092\u65bd\u3057\u307e\u3057\u305f\uff08ER thermAC\uff09\u3002\u66f4\u306b\u3001\u6700\u7d42\u7684\u306a\u6cbb\u7642\u85ac\u3092\u63a2\u7d22\u3059\u308b\u3053\u3068\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u30d2\u30c8\u7531\u6765\u306e\u8a66\u6599\u3092\u7528\u3044\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u3053\u3068\u304b\u3089\u3001\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u306eYu-Hua Tseng\u3089\u304c\u72ec\u81ea\u306b\u958b\u767a\u3057\u305f\u30d2\u30c8\u7531\u6765\u306e\u7d30\u80de\u304b\u3089\u5206\u5316\u8a98\u5c0e\u3057\u305f\u8910\u8272\u8102\u80aa\u7d30\u80de\u3092\u7528\u3044\u307e\u3057\u305f\u3002<\/p>\n
(4)<\/strong>\u4eca\u56de\u306e\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u7d50\u679c\u53ca\u3073\u77e5\u898b<\/strong><\/h4>\n![\"320170509_fig\"](\"https:\/\/www.waseda.jp\/top\/assets\/uploads\/2017\/05\/320170509_fig-610x450.png\")
\n\u307e\u305a\u6e29\u5ea6\u8a08\u3068\u3057\u3066\u306e\u7279\u6027\u3092\u78ba\u304b\u3081\uff08\u2460\uff09\u3001\u6b21\u306b\u8910\u8272\u8102\u80aa\u7d30\u80de\u3078\u5fdc\u7528\u3057\uff08\u2461\uff09\u3001\u540c\u4e00\u8996\u91ce\u5185\u306b\u3042\u308b\u8907\u6570\u306e\u7d30\u80de\u304c\u500b\u5225\u306b\u5fdc\u7b54\u3059\u308b\u300c\u500b\u6027\u300d\u3092\u898b\u308b\u3053\u3068\u306b\u521d\u3081\u3066\u6210\u529f\u3057\u307e\u3057\u305f\uff08\u2462\uff09\u3002
\n\u2460\u5f93\u6765\u306eER thermo yellow\u3068\u6bd4\u8f03\u3057\u3066\u3001\u5316\u5b66\u7684\u30fb\u7269\u7406\u7684\u306a\u5b89\u5b9a\u6027\u304c\u9ad8\u304f\u3001\u304b\u3064\u9577\u6642\u9593\u306e\u9855\u5fae\u93e1\u89b3\u5bdf\u306b\u3082\u8010\u3048\u3046\u308b\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u304b\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u30c1\u30fc\u30e0\u306e\u86cd\u5149\u6e29\u5ea6\u8a08\u306f\u3001\u305d\u306e\u5927\u304d\u3055\u304c\u5206\u5b50\u30b5\u30a4\u30ba\u3067\u3042\u308b\u3053\u3068\u304c\u7279\u5fb4\u3067\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u86cd\u5149\u6e29\u5ea6\u8a08\u3092\u7d30\u80de\u306b\u3075\u308a\u304b\u3051\u305f\u3060\u3051\u3067\u3001\u308f\u305a\u304b\u6570\u5206\u3067\u7d30\u80de\u306e\u4e2d\u306b\u5c0e\u5165\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u4ed6\u306e\u624b\u6cd5\u3068\u6bd4\u3079\u308b\u3068\u3001\u672c\u7814\u7a76\u30c1\u30fc\u30e0\u306e\u6280\u8853\u306f\u3001\u7d30\u80de\u306e\u7a2e\u985e\u3092\u9078\u3070\u305a\u3001\u3069\u3093\u306a\u7d30\u80de\u306b\u3067\u3082\u5bb9\u6613\u306b\u7d30\u80de\u5185\u3078\u5c0e\u5165\u3067\u304d\u308b\u70b9\u3067\u512a\u308c\u3066\u3044\u307e\u3059\u3002
\n\u2461\u30de\u30a6\u30b9\u304a\u3088\u3073\u30d2\u30c8\u7531\u6765\u306e\u8910\u8272\u8102\u80aa\u7d30\u80de\u3092\u85ac\u5264\u3067\u523a\u6fc0\u3057\u305f\u3068\u3053\u308d\u3001\u86cd\u5149\u6e29\u5ea6\u8a08\u306e\u86cd\u5149\u5f37\u5ea6\u304c\u5927\u304d\u304f\u5909\u5316\u3057\u307e\u3057\u305f\u3002\u7d30\u80de\u306e\u71b1\u7523\u751f\u91cf\u3092\u76f4\u63a5\u6e2c\u308b\u30de\u30a4\u30af\u30ed\u30ab\u30ed\u30ea\u30e1\u30c8\u30ea\u30fc\u3092\u7528\u3044\u305f\u6e2c\u5b9a\u3060\u3051\u3067\u306a\u304f\u3001\u3053\u308c\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u91cf\u3068\u3057\u3066\u9593\u63a5\u7684\u306b\u8a55\u4fa1\u3059\u308b\u624b\u6cd5\u3068\u3057\u3066\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u4ed6\u306e\u624b\u6cd5\uff08pH\u3084\u9178\u7d20\u306e\u6d88\u8cbb\u91cf\uff09\u304b\u3089\u5f97\u3089\u308c\u308b\u7d50\u679c\u3068\u3082\u3001\u975e\u5e38\u306b\u826f\u304f\u76f8\u95a2\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u3092\u542b\u3080\u8907\u6570\u306e\u7570\u306a\u308b\u8a08\u6e2c\u304b\u3089\u3001\u672c\u624b\u6cd5\u304c\u7d30\u80de\u306e\u71b1\u7523\u751f\u3092\u691c\u51fa\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002
\n\u2462\u7d30\u80de\u96c6\u56e3\u3092\u8a08\u6e2c\u306b\u7528\u3044\u308b\u5f93\u6765\u306e\u624b\u6cd5\u3067\u306f\u30011\u500b1\u500b\u306e\u7d30\u80de\u3092\u500b\u5225\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3053\u3053\u3067\u958b\u767a\u3057\u305f\u624b\u6cd5\u3092\u7528\u3044\u308c\u3070\u3001\u523a\u6fc0\u3092\u53d7\u3051\u305f\u8910\u8272\u8102\u80aa\u7d30\u80de\u306e\u6e29\u5ea6\u5909\u5316\u30921\u7d30\u80de\u3054\u3068\u306b\u89e3\u6790\u3067\u304d\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u305d\u308c\u305e\u308c\u306e\u7d30\u80de\u304c\u300c\u7570\u306a\u308b\u30bf\u30a4\u30df\u30f3\u30b0\u300d\u3067\u71b1\u7523\u751f\u3057\u3066\u6e29\u5ea6\u304c\u5909\u308f\u308b\u3068\u3044\u3046\u500b\u6027\u7684\u306a\u59ff\u3092\u6349\u3048\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n
(5)<\/strong>\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3068\u610f\u7fa9<\/strong><\/h4>\n\u8910\u8272\u8102\u80aa\u7d30\u80de\u306e\u71b1\u7523\u751f\u305d\u306e\u3082\u306e\u3092\u3001\u9593\u63a5\u7684\u306a\u6307\u6a19\u3092\u4ecb\u3055\u305a\u306b\u3001\u3088\u308a\u76f4\u63a5\u7684\u306b\u89b3\u5bdf\u3067\u304d\u308b\u7c21\u4fbf\u306a\u624b\u6cd5\u306e\u958b\u767a\u306b\u6210\u529f\u3057\u305f\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u540c\u69d8\u306b\u71b1\u7523\u751f\u6a5f\u80fd\u3092\u6301\u3064\u7b4b\u8089\u306e\u7d30\u80de\u306a\u3069\u3078\u3082\u3001\u672c\u6280\u8853\u306e\u9069\u7528\u5bfe\u8c61\u306f\u5e83\u304c\u3063\u3066\u3044\u304d\u307e\u3059\u3002\u4eca\u5f8c\u3001\u3053\u306e\u624b\u6cd5\u304c\u5275\u85ac\u306e\u305f\u3081\u306e\u57fa\u76e4\u6280\u8853\u306e\u4e00\u3064\u3068\u3057\u3066\u666e\u53ca\u3059\u308c\u3070\u3001\u4eca\u307e\u3067\u306b\u7121\u304b\u3063\u305f\u8996\u70b9\u304b\u3089\u71b1\u7523\u751f\u3092\u4fc3\u3059\u85ac\u3092\u898b\u51fa\u3057\u3001\u80a5\u6e80\u3092\u5f15\u304d\u91d1\u306b\u3057\u3066\u751f\u3058\u308b\u69d8\u3005\u306a\u75c5\u6c17\u306e\u6cbb\u7642\u85ac\u306e\u958b\u767a\u3078\u3068\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002
\n\u4eca\u56de\u3001\u672c\u7814\u7a76\u3092\u52b9\u7387\u3088\u304f\u9042\u884c\u3059\u308b\u305f\u3081\u306b\u3001\u56fd\u969b\u7684\u306a\u7814\u7a76\u30cf\u30d6\u3067\u3042\u308b\u5728\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u62e0\u70b9\u304c\u6700\u5927\u9650\u306b\u6d3b\u304b\u3055\u308c\u307e\u3057\u305f\u3002\u5b9f\u969b\u306b\u73fe\u5730\u3067\u9854\u3068\u9854\u3092\u3064\u304d\u5408\u308f\u305b\u3066\u3001\u65e5\u591c\u3001\u9855\u5fae\u93e1\u3092\u8997\u304d\u306a\u304c\u3089\u5fb9\u5e95\u7684\u306b\u8b70\u8ad6\u3092\u91cd\u306d\u3001\u5b9f\u9a13\u4e0a\u751f\u3058\u305f\u554f\u984c\u70b9\u306f\u3001\u7d20\u65e9\u304f\u5171\u540c\u7814\u7a76\u8005\u3078\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u3057\u3001\u554f\u984c\u89e3\u6c7a\u306b\u3042\u305f\u308a\u307e\u3057\u305f\u3002\u6700\u7d42\u7684\u306b\u3001\u30d2\u30c8\u30b5\u30f3\u30d7\u30eb\u3092\u7528\u3044\u305f\u5b9f\u9a13\u306e\u5fc5\u8981\u6027\u304c\u751f\u3058\u305f\u3053\u3068\u304b\u3089\u3001\u7b46\u982d\u8457\u8005\u306eR\u00f3kus\u6c0f\u304c\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u3078\u76f4\u63a5\u8d74\u304d\u3001\u7cbe\u529b\u7684\u306a\u5b9f\u9a13\u306b\u6c57\u3092\u6d41\u3057\u307e\u3057\u305f\u3002\u4e16\u754c\u4e2d\u3067\u30d0\u30a4\u30aa\u7814\u7a76\u306e\u7af6\u4e89\u304c\u6fc0\u5316\u3057\u3066\u3044\u308b\u4e2d\u3001\u5fc5\u8981\u306a\u6280\u8853\u3092\u3001\u56fd\u5883\u3092\u8d8a\u3048\u3066\u3067\u3082\u3044\u304b\u306b\u8fc5\u901f\u306b\u7d50\u96c6\u3067\u304d\u308b\u304b\u304c\u3001\u6211\u304c\u56fd\u304c\u79d1\u5b66\u6280\u8853\u7acb\u56fd\u3068\u3057\u3066\u4e16\u754c\u3092\u30ea\u30fc\u30c9\u3059\u308b\u3046\u3048\u3067\u3001\u4eca\u5f8c\u307e\u3059\u307e\u3059\u91cd\u8981\u306b\u306a\u308b\u3082\u306e\u3068\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002\u672c\u5171\u540c\u7814\u7a76\u3092\u901a\u3057\u3066\u5b9f\u5730\u306b\u69cb\u7bc9\u3057\u305f\u56fd\u969b\u7684\u306a\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306f\u3001\u4eca\u5f8c\u3082\u672c\u5b66\u306b\u3068\u3063\u3066\u5927\u304d\u306a\u5f37\u307f\u3068\u306a\u308a\u3001\u6211\u304c\u56fd\u3092\u4e2d\u5fc3\u3068\u3057\u3066\u65b0\u305f\u306a\u7814\u7a76\u6210\u679c\u3092\u751f\u307f\u51fa\u3057\u3066\u3044\u304f\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306b\u306a\u308b\u3082\u306e\u3068\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u00a0<\/strong><\/p>\n(6)<\/strong>\u4eca\u5f8c\u306e\u8ab2\u984c<\/strong><\/h4>\n\u523a\u6fc0\u3092\u53d7\u3051\u3066\u304b\u3089\u71b1\u7523\u751f\u307e\u3067\u3092\u3064\u306a\u3052\u308b\u60c5\u5831\u4f1d\u9054\u306e\u4ed5\u7d44\u307f\u304c\u3001\u7d30\u80de\u5185\u306b\u306f\u3042\u308a\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u898b\u3044\u3060\u3055\u308c\u305f\u7d30\u80de\u306e\u500b\u6027\u306f\u3001\u3053\u306e\u60c5\u5831\u4f1d\u9054\u306e\u3070\u3089\u3064\u304d\u306b\u7531\u6765\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u3069\u306e\u30b9\u30c6\u30c3\u30d7\u304c\u3069\u306e\u3088\u3046\u306b\u52b9\u3044\u3066\u3044\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u5206\u304b\u308a\u307e\u305b\u3093\u3002\u71b1\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u85ac\u5264\u5019\u88dc\u304c\u898b\u3064\u304b\u3063\u305f\u3068\u3057\u3066\u3001\u305d\u306e\u6a5f\u5e8f\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u3082\u30011\u7d30\u80de\u3067\u6e29\u5ea6\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3067\u304d\u308b\u672c\u6280\u8853\u3092\u4ed6\u306e\u7d30\u80de\u751f\u7269\u5b66\u7684\u3001\u5206\u5b50\u751f\u7269\u5b66\u7684\u306a\u624b\u6cd5\u3068\u5408\u308f\u305b\u3066\u3001\u71b1\u7523\u751f\u306b\u3064\u306a\u304c\u308b\u7d30\u80de\u5185\u60c5\u5831\u4f1d\u9054\u306e\u4ed5\u7d44\u307f\u3092\u3088\u308a\u8a73\u7d30\u306b\u7406\u89e3\u3059\u308b\u3053\u3068\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002
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(7)100<\/strong>\u5b57\u7a0b\u5ea6\u306e\u6982\u8981<\/strong><\/h4>\n\u71b1\u3092\u751f\u307f\u51fa\u3059\u8910\u8272\u8102\u80aa\u7d30\u80de\u306e\u6e29\u5ea6\u5909\u5316\u3092\u300c\u898b\u3048\u308b\u5316\u300d\u3059\u308b\u6280\u8853\u306e\u958b\u767a\u306b\u6210\u529f\u3002\u80a5\u6e80\u306e\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u63a2\u7d22\u306e\u305f\u3081\u306e\u57fa\u76e4\u6280\u8853\u3068\u3057\u3066\u671f\u5f85\u3002<\/p>\n
\u8ad6\u6587\u60c5\u5831<\/h5>\n\n- \u63b2\u8f09\u8a8c\uff1aScientific Reports<\/li>\n
- \u30bf\u30a4\u30c8\u30eb\uff1aOptical visualisation of thermogenesis in stimulated single-cell brown adipocytes<\/a><\/li>\n
- \u8457\u8005\uff1aR\u00f3kus Kriszt, Satoshi Arai\uff08WABIOS\uff09, Hideki Itoh, Michelle H. Lee, Anna G. Goralczyk, Xiu Min Ang, Aaron M. Cypess, Andrew P. White, Farnaz Shamzi, Ruidan Xue, Jung Yeol Lee, Sung-Chan Lee, Yanyan Hou\uff08WABIOS\uff09, Tetsuya Kitaguchi\uff08WABIOS\uff09, Thankiah Sudhaharan, Shin\u2019ichi Ishiwata\uff08WABIOS\uff09, E. Birgitte Lane, Young-Tae Chang, Yu-Hua Tseng*, Madoka Suzuki*\uff08WABIOS\u30fbJST\u3055\u304d\u304c\u3051\uff09 and Michael Raghunath*\u3000\uff08*Corresponding authors\uff09<\/li>\n
- \u8457\u8005\u6240\u5c5e\uff1a\u65e9\u7a32\u7530\u5927\u5b66\uff08WABIOS\uff09\u3001JST\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u56fd\u7acb\u5927\u5b66\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u79d1\u5b66\u6280\u8853\u7814\u7a76\u5e81\u3001\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u533b\u5b66\u90e8<\/li>\n
- DOI\uff1a10.1038\/s41598-017-00291-9<\/li>\n<\/ul>\n
\u53c2\u8003\u6587\u732e<\/h5>\n\n- 1\uff09Y.-H. Tseng\uff08\u672c\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u8ad6\u6587\u306e\u5171\u8457\u8005\uff09, A. M. Cypess and C. R. Kahn, Nat. Rev. Drug Discov.<\/em>, 2010, 9<\/strong>, 465\u2013482.<\/li>\n
- 2) S. Arai, S.-C. Lee, D. Zhai, M. Suzuki and Y.-T. Chang, Sci. Rep.<\/em>, 2014, 4<\/strong>, 6701.<\/li>\n
- 3) M. Suzuki, V. Zeeb, S. Arai, K. Oyama and S. Ishiwata, Nat. Methods<\/em>, 2015, 12<\/strong>, 802\u2013803.\uff08\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\uff09<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"
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\n
\u5de6\u304b\u3089R\u00f3kus Kriszt\u6c0f\u3001Michael Raghunath\u535a\u58eb\u3001\u65b0\u4e95\u654f\u535a\u58eb<\/p><\/div><\/p>\n
(3)<\/strong>\u305d\u306e\u305f\u3081\u306b\u65b0\u3057\u304f\u958b\u767a\u3057\u305f\u624b\u6cd5<\/strong><\/h4>\n\u8910\u8272\u8102\u80aa\u7d30\u80de\u3067\u306e\u8a08\u6e2c\u306b\u3068\u3063\u3066\u3001\u3088\u308a\u9069\u3057\u305f\u5316\u5b66\u7684\u306a\u7279\u6027\u3092\u6301\u305f\u305b\u308b\u305f\u3081\u306b\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u56fd\u7acb\u5927\u5b66\u306eYoung-Tae Chang\u6559\u6388\u3089\u304c\u3001\u4eca\u307e\u3067\u306b\u5171\u540c\u3067\u958b\u767a\u3057\u3066\u3044\u305f\u86cd\u5149\u6e29\u5ea6\u8a08\uff08ER thermo yellow\uff1a\u53c2\u8003\u6587\u732e2\uff09\u306b\u6539\u826f\u3092\u65bd\u3057\u307e\u3057\u305f\uff08ER thermAC\uff09\u3002\u66f4\u306b\u3001\u6700\u7d42\u7684\u306a\u6cbb\u7642\u85ac\u3092\u63a2\u7d22\u3059\u308b\u3053\u3068\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u30d2\u30c8\u7531\u6765\u306e\u8a66\u6599\u3092\u7528\u3044\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u3053\u3068\u304b\u3089\u3001\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u306eYu-Hua Tseng\u3089\u304c\u72ec\u81ea\u306b\u958b\u767a\u3057\u305f\u30d2\u30c8\u7531\u6765\u306e\u7d30\u80de\u304b\u3089\u5206\u5316\u8a98\u5c0e\u3057\u305f\u8910\u8272\u8102\u80aa\u7d30\u80de\u3092\u7528\u3044\u307e\u3057\u305f\u3002<\/p>\n
(4)<\/strong>\u4eca\u56de\u306e\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u7d50\u679c\u53ca\u3073\u77e5\u898b<\/strong><\/h4>\n
\n\u307e\u305a\u6e29\u5ea6\u8a08\u3068\u3057\u3066\u306e\u7279\u6027\u3092\u78ba\u304b\u3081\uff08\u2460\uff09\u3001\u6b21\u306b\u8910\u8272\u8102\u80aa\u7d30\u80de\u3078\u5fdc\u7528\u3057\uff08\u2461\uff09\u3001\u540c\u4e00\u8996\u91ce\u5185\u306b\u3042\u308b\u8907\u6570\u306e\u7d30\u80de\u304c\u500b\u5225\u306b\u5fdc\u7b54\u3059\u308b\u300c\u500b\u6027\u300d\u3092\u898b\u308b\u3053\u3068\u306b\u521d\u3081\u3066\u6210\u529f\u3057\u307e\u3057\u305f\uff08\u2462\uff09\u3002
\n\u2460\u5f93\u6765\u306eER thermo yellow\u3068\u6bd4\u8f03\u3057\u3066\u3001\u5316\u5b66\u7684\u30fb\u7269\u7406\u7684\u306a\u5b89\u5b9a\u6027\u304c\u9ad8\u304f\u3001\u304b\u3064\u9577\u6642\u9593\u306e\u9855\u5fae\u93e1\u89b3\u5bdf\u306b\u3082\u8010\u3048\u3046\u308b\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u304b\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u30c1\u30fc\u30e0\u306e\u86cd\u5149\u6e29\u5ea6\u8a08\u306f\u3001\u305d\u306e\u5927\u304d\u3055\u304c\u5206\u5b50\u30b5\u30a4\u30ba\u3067\u3042\u308b\u3053\u3068\u304c\u7279\u5fb4\u3067\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u86cd\u5149\u6e29\u5ea6\u8a08\u3092\u7d30\u80de\u306b\u3075\u308a\u304b\u3051\u305f\u3060\u3051\u3067\u3001\u308f\u305a\u304b\u6570\u5206\u3067\u7d30\u80de\u306e\u4e2d\u306b\u5c0e\u5165\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u4ed6\u306e\u624b\u6cd5\u3068\u6bd4\u3079\u308b\u3068\u3001\u672c\u7814\u7a76\u30c1\u30fc\u30e0\u306e\u6280\u8853\u306f\u3001\u7d30\u80de\u306e\u7a2e\u985e\u3092\u9078\u3070\u305a\u3001\u3069\u3093\u306a\u7d30\u80de\u306b\u3067\u3082\u5bb9\u6613\u306b\u7d30\u80de\u5185\u3078\u5c0e\u5165\u3067\u304d\u308b\u70b9\u3067\u512a\u308c\u3066\u3044\u307e\u3059\u3002
\n\u2461\u30de\u30a6\u30b9\u304a\u3088\u3073\u30d2\u30c8\u7531\u6765\u306e\u8910\u8272\u8102\u80aa\u7d30\u80de\u3092\u85ac\u5264\u3067\u523a\u6fc0\u3057\u305f\u3068\u3053\u308d\u3001\u86cd\u5149\u6e29\u5ea6\u8a08\u306e\u86cd\u5149\u5f37\u5ea6\u304c\u5927\u304d\u304f\u5909\u5316\u3057\u307e\u3057\u305f\u3002\u7d30\u80de\u306e\u71b1\u7523\u751f\u91cf\u3092\u76f4\u63a5\u6e2c\u308b\u30de\u30a4\u30af\u30ed\u30ab\u30ed\u30ea\u30e1\u30c8\u30ea\u30fc\u3092\u7528\u3044\u305f\u6e2c\u5b9a\u3060\u3051\u3067\u306a\u304f\u3001\u3053\u308c\u3092\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u91cf\u3068\u3057\u3066\u9593\u63a5\u7684\u306b\u8a55\u4fa1\u3059\u308b\u624b\u6cd5\u3068\u3057\u3066\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u4ed6\u306e\u624b\u6cd5\uff08pH\u3084\u9178\u7d20\u306e\u6d88\u8cbb\u91cf\uff09\u304b\u3089\u5f97\u3089\u308c\u308b\u7d50\u679c\u3068\u3082\u3001\u975e\u5e38\u306b\u826f\u304f\u76f8\u95a2\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u3092\u542b\u3080\u8907\u6570\u306e\u7570\u306a\u308b\u8a08\u6e2c\u304b\u3089\u3001\u672c\u624b\u6cd5\u304c\u7d30\u80de\u306e\u71b1\u7523\u751f\u3092\u691c\u51fa\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002
\n\u2462\u7d30\u80de\u96c6\u56e3\u3092\u8a08\u6e2c\u306b\u7528\u3044\u308b\u5f93\u6765\u306e\u624b\u6cd5\u3067\u306f\u30011\u500b1\u500b\u306e\u7d30\u80de\u3092\u500b\u5225\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3053\u3053\u3067\u958b\u767a\u3057\u305f\u624b\u6cd5\u3092\u7528\u3044\u308c\u3070\u3001\u523a\u6fc0\u3092\u53d7\u3051\u305f\u8910\u8272\u8102\u80aa\u7d30\u80de\u306e\u6e29\u5ea6\u5909\u5316\u30921\u7d30\u80de\u3054\u3068\u306b\u89e3\u6790\u3067\u304d\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u305d\u308c\u305e\u308c\u306e\u7d30\u80de\u304c\u300c\u7570\u306a\u308b\u30bf\u30a4\u30df\u30f3\u30b0\u300d\u3067\u71b1\u7523\u751f\u3057\u3066\u6e29\u5ea6\u304c\u5909\u308f\u308b\u3068\u3044\u3046\u500b\u6027\u7684\u306a\u59ff\u3092\u6349\u3048\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n
(5)<\/strong>\u7814\u7a76\u306e\u6ce2\u53ca\u52b9\u679c\u3068\u610f\u7fa9<\/strong><\/h4>\n\u8910\u8272\u8102\u80aa\u7d30\u80de\u306e\u71b1\u7523\u751f\u305d\u306e\u3082\u306e\u3092\u3001\u9593\u63a5\u7684\u306a\u6307\u6a19\u3092\u4ecb\u3055\u305a\u306b\u3001\u3088\u308a\u76f4\u63a5\u7684\u306b\u89b3\u5bdf\u3067\u304d\u308b\u7c21\u4fbf\u306a\u624b\u6cd5\u306e\u958b\u767a\u306b\u6210\u529f\u3057\u305f\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u540c\u69d8\u306b\u71b1\u7523\u751f\u6a5f\u80fd\u3092\u6301\u3064\u7b4b\u8089\u306e\u7d30\u80de\u306a\u3069\u3078\u3082\u3001\u672c\u6280\u8853\u306e\u9069\u7528\u5bfe\u8c61\u306f\u5e83\u304c\u3063\u3066\u3044\u304d\u307e\u3059\u3002\u4eca\u5f8c\u3001\u3053\u306e\u624b\u6cd5\u304c\u5275\u85ac\u306e\u305f\u3081\u306e\u57fa\u76e4\u6280\u8853\u306e\u4e00\u3064\u3068\u3057\u3066\u666e\u53ca\u3059\u308c\u3070\u3001\u4eca\u307e\u3067\u306b\u7121\u304b\u3063\u305f\u8996\u70b9\u304b\u3089\u71b1\u7523\u751f\u3092\u4fc3\u3059\u85ac\u3092\u898b\u51fa\u3057\u3001\u80a5\u6e80\u3092\u5f15\u304d\u91d1\u306b\u3057\u3066\u751f\u3058\u308b\u69d8\u3005\u306a\u75c5\u6c17\u306e\u6cbb\u7642\u85ac\u306e\u958b\u767a\u3078\u3068\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002
\n\u4eca\u56de\u3001\u672c\u7814\u7a76\u3092\u52b9\u7387\u3088\u304f\u9042\u884c\u3059\u308b\u305f\u3081\u306b\u3001\u56fd\u969b\u7684\u306a\u7814\u7a76\u30cf\u30d6\u3067\u3042\u308b\u5728\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u62e0\u70b9\u304c\u6700\u5927\u9650\u306b\u6d3b\u304b\u3055\u308c\u307e\u3057\u305f\u3002\u5b9f\u969b\u306b\u73fe\u5730\u3067\u9854\u3068\u9854\u3092\u3064\u304d\u5408\u308f\u305b\u3066\u3001\u65e5\u591c\u3001\u9855\u5fae\u93e1\u3092\u8997\u304d\u306a\u304c\u3089\u5fb9\u5e95\u7684\u306b\u8b70\u8ad6\u3092\u91cd\u306d\u3001\u5b9f\u9a13\u4e0a\u751f\u3058\u305f\u554f\u984c\u70b9\u306f\u3001\u7d20\u65e9\u304f\u5171\u540c\u7814\u7a76\u8005\u3078\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u3057\u3001\u554f\u984c\u89e3\u6c7a\u306b\u3042\u305f\u308a\u307e\u3057\u305f\u3002\u6700\u7d42\u7684\u306b\u3001\u30d2\u30c8\u30b5\u30f3\u30d7\u30eb\u3092\u7528\u3044\u305f\u5b9f\u9a13\u306e\u5fc5\u8981\u6027\u304c\u751f\u3058\u305f\u3053\u3068\u304b\u3089\u3001\u7b46\u982d\u8457\u8005\u306eR\u00f3kus\u6c0f\u304c\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u3078\u76f4\u63a5\u8d74\u304d\u3001\u7cbe\u529b\u7684\u306a\u5b9f\u9a13\u306b\u6c57\u3092\u6d41\u3057\u307e\u3057\u305f\u3002\u4e16\u754c\u4e2d\u3067\u30d0\u30a4\u30aa\u7814\u7a76\u306e\u7af6\u4e89\u304c\u6fc0\u5316\u3057\u3066\u3044\u308b\u4e2d\u3001\u5fc5\u8981\u306a\u6280\u8853\u3092\u3001\u56fd\u5883\u3092\u8d8a\u3048\u3066\u3067\u3082\u3044\u304b\u306b\u8fc5\u901f\u306b\u7d50\u96c6\u3067\u304d\u308b\u304b\u304c\u3001\u6211\u304c\u56fd\u304c\u79d1\u5b66\u6280\u8853\u7acb\u56fd\u3068\u3057\u3066\u4e16\u754c\u3092\u30ea\u30fc\u30c9\u3059\u308b\u3046\u3048\u3067\u3001\u4eca\u5f8c\u307e\u3059\u307e\u3059\u91cd\u8981\u306b\u306a\u308b\u3082\u306e\u3068\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002\u672c\u5171\u540c\u7814\u7a76\u3092\u901a\u3057\u3066\u5b9f\u5730\u306b\u69cb\u7bc9\u3057\u305f\u56fd\u969b\u7684\u306a\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306f\u3001\u4eca\u5f8c\u3082\u672c\u5b66\u306b\u3068\u3063\u3066\u5927\u304d\u306a\u5f37\u307f\u3068\u306a\u308a\u3001\u6211\u304c\u56fd\u3092\u4e2d\u5fc3\u3068\u3057\u3066\u65b0\u305f\u306a\u7814\u7a76\u6210\u679c\u3092\u751f\u307f\u51fa\u3057\u3066\u3044\u304f\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306b\u306a\u308b\u3082\u306e\u3068\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u00a0<\/strong><\/p>\n(6)<\/strong>\u4eca\u5f8c\u306e\u8ab2\u984c<\/strong><\/h4>\n\u523a\u6fc0\u3092\u53d7\u3051\u3066\u304b\u3089\u71b1\u7523\u751f\u307e\u3067\u3092\u3064\u306a\u3052\u308b\u60c5\u5831\u4f1d\u9054\u306e\u4ed5\u7d44\u307f\u304c\u3001\u7d30\u80de\u5185\u306b\u306f\u3042\u308a\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u898b\u3044\u3060\u3055\u308c\u305f\u7d30\u80de\u306e\u500b\u6027\u306f\u3001\u3053\u306e\u60c5\u5831\u4f1d\u9054\u306e\u3070\u3089\u3064\u304d\u306b\u7531\u6765\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u3069\u306e\u30b9\u30c6\u30c3\u30d7\u304c\u3069\u306e\u3088\u3046\u306b\u52b9\u3044\u3066\u3044\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u5206\u304b\u308a\u307e\u305b\u3093\u3002\u71b1\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u85ac\u5264\u5019\u88dc\u304c\u898b\u3064\u304b\u3063\u305f\u3068\u3057\u3066\u3001\u305d\u306e\u6a5f\u5e8f\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u3082\u30011\u7d30\u80de\u3067\u6e29\u5ea6\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3067\u304d\u308b\u672c\u6280\u8853\u3092\u4ed6\u306e\u7d30\u80de\u751f\u7269\u5b66\u7684\u3001\u5206\u5b50\u751f\u7269\u5b66\u7684\u306a\u624b\u6cd5\u3068\u5408\u308f\u305b\u3066\u3001\u71b1\u7523\u751f\u306b\u3064\u306a\u304c\u308b\u7d30\u80de\u5185\u60c5\u5831\u4f1d\u9054\u306e\u4ed5\u7d44\u307f\u3092\u3088\u308a\u8a73\u7d30\u306b\u7406\u89e3\u3059\u308b\u3053\u3068\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002
\n\u307e\u305f\u4eca\u56de\u5f97\u3089\u308c\u305f\u30c7\u30fc\u30bf\u306f\u3001\u3042\u304f\u307e\u3067\u5b9a\u6027\u7684\u306a\u6307\u6a19\u3067\u3042\u308a\u3001\u7d30\u80de\u5185\u306e\u6e29\u5ea6\u304c\u5b9f\u969b\u306b\u4f55\u2103\u4e0a\u6607\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u3068\u3044\u3046\u5b9a\u91cf\u7684\u306a\u8b70\u8ad6\u3068\u306f\u533a\u5225\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u73fe\u5728\u3001\u7d30\u80de\u306e\u81ea\u767a\u7684\u306a\u71b1\u7523\u751f\u306b\u7531\u6765\u3059\u308b\u7d30\u80de\u5185\u6e29\u5ea6\u306b\u3064\u3044\u3066\u306e\u610f\u898b\u306f\u5927\u304d\u304f\u5272\u308c\u3066\u304a\u308a\u3001\u5b9a\u91cf\u7684\u306a\u8b70\u8ad6\u306f\u672a\u3060\u306b\u6b8b\u3055\u308c\u3066\u3044\u308b\u91cd\u8981\u306a\u8ab2\u984c\u3067\u3059\uff08\u53c2\u8003\u6587\u732e3\uff09\u3002\u5b9a\u91cf\u6027\u3092\u5411\u4e0a\u3055\u305b\u308b\u6539\u826f\u3092\u65bd\u3059\u3053\u3068\u3067\u3001\u3053\u3046\u3057\u305f\u8ab2\u984c\u306e\u89e3\u6c7a\u306b\u5411\u3051\u305f\u4e00\u3064\u306e\u7cf8\u53e3\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n
(7)100<\/strong>\u5b57\u7a0b\u5ea6\u306e\u6982\u8981<\/strong><\/h4>\n\u71b1\u3092\u751f\u307f\u51fa\u3059\u8910\u8272\u8102\u80aa\u7d30\u80de\u306e\u6e29\u5ea6\u5909\u5316\u3092\u300c\u898b\u3048\u308b\u5316\u300d\u3059\u308b\u6280\u8853\u306e\u958b\u767a\u306b\u6210\u529f\u3002\u80a5\u6e80\u306e\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u63a2\u7d22\u306e\u305f\u3081\u306e\u57fa\u76e4\u6280\u8853\u3068\u3057\u3066\u671f\u5f85\u3002<\/p>\n
\u8ad6\u6587\u60c5\u5831<\/h5>\n\n- \u63b2\u8f09\u8a8c\uff1aScientific Reports<\/li>\n
- \u30bf\u30a4\u30c8\u30eb\uff1aOptical visualisation of thermogenesis in stimulated single-cell brown adipocytes<\/a><\/li>\n
- \u8457\u8005\uff1aR\u00f3kus Kriszt, Satoshi Arai\uff08WABIOS\uff09, Hideki Itoh, Michelle H. Lee, Anna G. Goralczyk, Xiu Min Ang, Aaron M. Cypess, Andrew P. White, Farnaz Shamzi, Ruidan Xue, Jung Yeol Lee, Sung-Chan Lee, Yanyan Hou\uff08WABIOS\uff09, Tetsuya Kitaguchi\uff08WABIOS\uff09, Thankiah Sudhaharan, Shin\u2019ichi Ishiwata\uff08WABIOS\uff09, E. Birgitte Lane, Young-Tae Chang, Yu-Hua Tseng*, Madoka Suzuki*\uff08WABIOS\u30fbJST\u3055\u304d\u304c\u3051\uff09 and Michael Raghunath*\u3000\uff08*Corresponding authors\uff09<\/li>\n
- \u8457\u8005\u6240\u5c5e\uff1a\u65e9\u7a32\u7530\u5927\u5b66\uff08WABIOS\uff09\u3001JST\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u56fd\u7acb\u5927\u5b66\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u79d1\u5b66\u6280\u8853\u7814\u7a76\u5e81\u3001\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u533b\u5b66\u90e8<\/li>\n
- DOI\uff1a10.1038\/s41598-017-00291-9<\/li>\n<\/ul>\n
\u53c2\u8003\u6587\u732e<\/h5>\n\n- 1\uff09Y.-H. Tseng\uff08\u672c\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u8ad6\u6587\u306e\u5171\u8457\u8005\uff09, A. M. Cypess and C. R. Kahn, Nat. Rev. Drug Discov.<\/em>, 2010, 9<\/strong>, 465\u2013482.<\/li>\n
- 2) S. Arai, S.-C. Lee, D. Zhai, M. Suzuki and Y.-T. Chang, Sci. Rep.<\/em>, 2014, 4<\/strong>, 6701.<\/li>\n
- 3) M. Suzuki, V. Zeeb, S. Arai, K. Oyama and S. Ishiwata, Nat. Methods<\/em>, 2015, 12<\/strong>, 802\u2013803.\uff08\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\uff09<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"
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(7)100<\/strong>\u5b57\u7a0b\u5ea6\u306e\u6982\u8981<\/strong><\/h4>\n\u71b1\u3092\u751f\u307f\u51fa\u3059\u8910\u8272\u8102\u80aa\u7d30\u80de\u306e\u6e29\u5ea6\u5909\u5316\u3092\u300c\u898b\u3048\u308b\u5316\u300d\u3059\u308b\u6280\u8853\u306e\u958b\u767a\u306b\u6210\u529f\u3002\u80a5\u6e80\u306e\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u63a2\u7d22\u306e\u305f\u3081\u306e\u57fa\u76e4\u6280\u8853\u3068\u3057\u3066\u671f\u5f85\u3002<\/p>\n
\u8ad6\u6587\u60c5\u5831<\/h5>\n\n- \u63b2\u8f09\u8a8c\uff1aScientific Reports<\/li>\n
- \u30bf\u30a4\u30c8\u30eb\uff1aOptical visualisation of thermogenesis in stimulated single-cell brown adipocytes<\/a><\/li>\n
- \u8457\u8005\uff1aR\u00f3kus Kriszt, Satoshi Arai\uff08WABIOS\uff09, Hideki Itoh, Michelle H. Lee, Anna G. Goralczyk, Xiu Min Ang, Aaron M. Cypess, Andrew P. White, Farnaz Shamzi, Ruidan Xue, Jung Yeol Lee, Sung-Chan Lee, Yanyan Hou\uff08WABIOS\uff09, Tetsuya Kitaguchi\uff08WABIOS\uff09, Thankiah Sudhaharan, Shin\u2019ichi Ishiwata\uff08WABIOS\uff09, E. Birgitte Lane, Young-Tae Chang, Yu-Hua Tseng*, Madoka Suzuki*\uff08WABIOS\u30fbJST\u3055\u304d\u304c\u3051\uff09 and Michael Raghunath*\u3000\uff08*Corresponding authors\uff09<\/li>\n
- \u8457\u8005\u6240\u5c5e\uff1a\u65e9\u7a32\u7530\u5927\u5b66\uff08WABIOS\uff09\u3001JST\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u56fd\u7acb\u5927\u5b66\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u79d1\u5b66\u6280\u8853\u7814\u7a76\u5e81\u3001\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u533b\u5b66\u90e8<\/li>\n
- DOI\uff1a10.1038\/s41598-017-00291-9<\/li>\n<\/ul>\n
\u53c2\u8003\u6587\u732e<\/h5>\n\n- 1\uff09Y.-H. Tseng\uff08\u672c\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u8ad6\u6587\u306e\u5171\u8457\u8005\uff09, A. M. Cypess and C. R. Kahn, Nat. Rev. Drug Discov.<\/em>, 2010, 9<\/strong>, 465\u2013482.<\/li>\n
- 2) S. Arai, S.-C. Lee, D. Zhai, M. Suzuki and Y.-T. Chang, Sci. Rep.<\/em>, 2014, 4<\/strong>, 6701.<\/li>\n
- 3) M. Suzuki, V. Zeeb, S. Arai, K. Oyama and S. Ishiwata, Nat. Methods<\/em>, 2015, 12<\/strong>, 802\u2013803.\uff08\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\uff09<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"
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(7)100<\/strong>\u5b57\u7a0b\u5ea6\u306e\u6982\u8981<\/strong><\/h4>\n\u71b1\u3092\u751f\u307f\u51fa\u3059\u8910\u8272\u8102\u80aa\u7d30\u80de\u306e\u6e29\u5ea6\u5909\u5316\u3092\u300c\u898b\u3048\u308b\u5316\u300d\u3059\u308b\u6280\u8853\u306e\u958b\u767a\u306b\u6210\u529f\u3002\u80a5\u6e80\u306e\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u63a2\u7d22\u306e\u305f\u3081\u306e\u57fa\u76e4\u6280\u8853\u3068\u3057\u3066\u671f\u5f85\u3002<\/p>\n
\u8ad6\u6587\u60c5\u5831<\/h5>\n\n- \u63b2\u8f09\u8a8c\uff1aScientific Reports<\/li>\n
- \u30bf\u30a4\u30c8\u30eb\uff1aOptical visualisation of thermogenesis in stimulated single-cell brown adipocytes<\/a><\/li>\n
- \u8457\u8005\uff1aR\u00f3kus Kriszt, Satoshi Arai\uff08WABIOS\uff09, Hideki Itoh, Michelle H. Lee, Anna G. Goralczyk, Xiu Min Ang, Aaron M. Cypess, Andrew P. White, Farnaz Shamzi, Ruidan Xue, Jung Yeol Lee, Sung-Chan Lee, Yanyan Hou\uff08WABIOS\uff09, Tetsuya Kitaguchi\uff08WABIOS\uff09, Thankiah Sudhaharan, Shin\u2019ichi Ishiwata\uff08WABIOS\uff09, E. Birgitte Lane, Young-Tae Chang, Yu-Hua Tseng*, Madoka Suzuki*\uff08WABIOS\u30fbJST\u3055\u304d\u304c\u3051\uff09 and Michael Raghunath*\u3000\uff08*Corresponding authors\uff09<\/li>\n
- \u8457\u8005\u6240\u5c5e\uff1a\u65e9\u7a32\u7530\u5927\u5b66\uff08WABIOS\uff09\u3001JST\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u56fd\u7acb\u5927\u5b66\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u79d1\u5b66\u6280\u8853\u7814\u7a76\u5e81\u3001\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u533b\u5b66\u90e8<\/li>\n
- DOI\uff1a10.1038\/s41598-017-00291-9<\/li>\n<\/ul>\n
\u53c2\u8003\u6587\u732e<\/h5>\n\n- 1\uff09Y.-H. Tseng\uff08\u672c\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u8ad6\u6587\u306e\u5171\u8457\u8005\uff09, A. M. Cypess and C. R. Kahn, Nat. Rev. Drug Discov.<\/em>, 2010, 9<\/strong>, 465\u2013482.<\/li>\n
- 2) S. Arai, S.-C. Lee, D. Zhai, M. Suzuki and Y.-T. Chang, Sci. Rep.<\/em>, 2014, 4<\/strong>, 6701.<\/li>\n
- 3) M. Suzuki, V. Zeeb, S. Arai, K. Oyama and S. Ishiwata, Nat. Methods<\/em>, 2015, 12<\/strong>, 802\u2013803.\uff08\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\uff09<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"
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\u8ad6\u6587\u60c5\u5831<\/h5>\n\n- \u63b2\u8f09\u8a8c\uff1aScientific Reports<\/li>\n
- \u30bf\u30a4\u30c8\u30eb\uff1aOptical visualisation of thermogenesis in stimulated single-cell brown adipocytes<\/a><\/li>\n
- \u8457\u8005\uff1aR\u00f3kus Kriszt, Satoshi Arai\uff08WABIOS\uff09, Hideki Itoh, Michelle H. Lee, Anna G. Goralczyk, Xiu Min Ang, Aaron M. Cypess, Andrew P. White, Farnaz Shamzi, Ruidan Xue, Jung Yeol Lee, Sung-Chan Lee, Yanyan Hou\uff08WABIOS\uff09, Tetsuya Kitaguchi\uff08WABIOS\uff09, Thankiah Sudhaharan, Shin\u2019ichi Ishiwata\uff08WABIOS\uff09, E. Birgitte Lane, Young-Tae Chang, Yu-Hua Tseng*, Madoka Suzuki*\uff08WABIOS\u30fbJST\u3055\u304d\u304c\u3051\uff09 and Michael Raghunath*\u3000\uff08*Corresponding authors\uff09<\/li>\n
- \u8457\u8005\u6240\u5c5e\uff1a\u65e9\u7a32\u7530\u5927\u5b66\uff08WABIOS\uff09\u3001JST\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u56fd\u7acb\u5927\u5b66\u3001\u30b7\u30f3\u30ac\u30dd\u30fc\u30eb\u79d1\u5b66\u6280\u8853\u7814\u7a76\u5e81\u3001\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u533b\u5b66\u90e8<\/li>\n
- DOI\uff1a10.1038\/s41598-017-00291-9<\/li>\n<\/ul>\n
\u53c2\u8003\u6587\u732e<\/h5>\n\n- 1\uff09Y.-H. Tseng\uff08\u672c\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u8ad6\u6587\u306e\u5171\u8457\u8005\uff09, A. M. Cypess and C. R. Kahn, Nat. Rev. Drug Discov.<\/em>, 2010, 9<\/strong>, 465\u2013482.<\/li>\n
- 2) S. Arai, S.-C. Lee, D. Zhai, M. Suzuki and Y.-T. Chang, Sci. Rep.<\/em>, 2014, 4<\/strong>, 6701.<\/li>\n
- 3) M. Suzuki, V. Zeeb, S. Arai, K. Oyama and S. Ishiwata, Nat. Methods<\/em>, 2015, 12<\/strong>, 802\u2013803.\uff08\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\uff09<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"
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\u53c2\u8003\u6587\u732e<\/h5>\n\n- 1\uff09Y.-H. Tseng\uff08\u672c\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u8ad6\u6587\u306e\u5171\u8457\u8005\uff09, A. M. Cypess and C. R. Kahn, Nat. Rev. Drug Discov.<\/em>, 2010, 9<\/strong>, 465\u2013482.<\/li>\n
- 2) S. Arai, S.-C. Lee, D. Zhai, M. Suzuki and Y.-T. Chang, Sci. Rep.<\/em>, 2014, 4<\/strong>, 6701.<\/li>\n
- 3) M. Suzuki, V. Zeeb, S. Arai, K. Oyama and S. Ishiwata, Nat. Methods<\/em>, 2015, 12<\/strong>, 802\u2013803.\uff08\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\uff09<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"
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