{"id":835,"date":"2016-07-15T22:00:09","date_gmt":"2016-07-15T13:00:09","guid":{"rendered":"http:\/\/www.waseda.jp\/inst\/nanolife\/?p=835"},"modified":"2016-07-26T18:56:46","modified_gmt":"2016-07-26T09:56:46","slug":"%e3%80%90%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9%e3%80%91%e7%b2%be%e7%a5%9e%e9%81%85%e6%bb%9e%e5%8e%9f%e5%9b%a0%e9%81%ba%e4%bc%9d%e5%ad%90%e7%94%a3%e7%89%a9%e3%82%bb%e3%83%ac","status":"publish","type":"post","link":"https:\/\/www.waseda.jp\/inst\/nanolife\/news\/2016\/07\/15\/835\/","title":{"rendered":"\u3010\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u3011\u7cbe\u795e\u9045\u6ede\u539f\u56e0\u907a\u4f1d\u5b50\u7523\u7269\u30bb\u30ec\u30d6\u30ed\u30f3\u306e\u6297\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u7d30\u80de\u4fdd\u8b77\u6a5f\u80fd\u3092\u89e3\u660e"},"content":{"rendered":"<p>\u65e9\u7a32\u7530\u5927\u5b66\u30ca\u30ce\u30fb\u30e9\u30a4\u30d5\u5275\u65b0\u7814\u7a76\u6a5f\u69cb\u306e<a class=\"addicn\" href=\"https:\/\/researchers.waseda.jp\/profile\/ja.bdfa14e16506e71cee79f425781edf7c.html\" target=\"_blank\">\u6fa4\u6751\u76f4\u54c9\uff08\u3055\u308f\u3080\u3089\u306a\u304a\u3084\uff09\u4e3b\u4efb\u7814\u7a76\u54e1\uff08\u7814\u7a76\u9662\u51c6\u6559\u6388\uff09<\/a>\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u7cbe\u795e\u9045\u6ede\u539f\u56e0\u907a\u4f1d\u5b50\u3067\u3042\u308b\u30bb\u30ec\u30d6\u30ed\u30f3\uff08Cereblon\u3001\u4ee5\u4e0bCRBN\uff09\u304c\u3001\u6297\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u7d30\u80de\u4fdd\u8b77\u6a5f\u80fd\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>CRBN\u306f\u7cbe\u795e\u9045\u6ede\u3092\u983b\u767a\u3059\u308b\u5bb6\u7cfb\u306e\u89e3\u6790\u304b\u3089\u5f97\u3089\u308c\u3066\u304d\u305f\u907a\u4f1d\u5b50\u7523\u7269\u3067\u3059\u3002CRBN\u306e\u5909\u7570\u306e\u898b\u3089\u308c\u308b\u7cbe\u795e\u9045\u6ede\u306e\u5bb6\u7cfb\u306e\u60a3\u8005\u3067\u306f\u3001CRBN\u304c\u5207\u65ad\u3092\u53d7\u3051\u308b\u3053\u3068\u306b\u3088\u308a\u3001CRBN\u306e\u6a5f\u80fd\u304c\u55aa\u5931\u3057\u3001\u7cbe\u795e\u9045\u6ede\u304c\u767a\u75c7\u3059\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002CRBN\u306f\u767a\u898b\u5f53\u521d\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3067\u50cd\u304fLon\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u9ad8\u3044\u30a2\u30df\u30ce\u9178\u76f8\u540c\u6027\u3092\u793a\u3059\u3053\u3068\u304b\u3089\u3001Lon\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u540c\u69d8\u306b\u6297\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u7d30\u80de\u4fdd\u8b77\u6a5f\u80fd\u3092\u6301\u3064\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001CRBN \u304c\u69d8\u3005\u306a\u7d30\u80de\u5c0f\u5668\u5b98\u306b\u5b58\u5728\u3059\u308b\u591a\u6a5f\u80fd\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u305f\u3081\u3001\u6a5f\u80fd\u3092\u691c\u8a3c\u3059\u308b\u306e\u306f\u56f0\u96e3\u3067\u3057\u305f\u3002<\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001CRBN\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u79fb\u884c\u30b7\u30b0\u30ca\u30eb (Mitochondria targeting sequence; MTS) \u3092\u4ed8\u52a0\u3057\u3066\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u7279\u7570\u7684\u306b\u767a\u73fe\u3055\u305b\u3001CRBN \u306eLon \u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u3057\u3066\u306e\u6a5f\u80fd\u3092\u89e3\u6790\u3059\u308b\u3068\u3044\u3046\u624b\u6cd5\u3092\u958b\u767a\u3057\u3001\u691c\u8a3c\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001CRBN \u306fLon \u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u540c\u69d8\u306b\u3001\u6297\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u7d30\u80de\u4fdd\u8b77\u6a5f\u80fd\u3092\u6301\u3063\u3066\u3044\u308b\u4e8b\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u4eca\u5f8c\u3001\u672c\u7814\u7a76\u306b\u3088\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u304a\u3051\u308bCRBN\u306e\u6a5f\u80fd\u89e3\u660e\u304c\u3001\u7cbe\u795e\u9045\u6ede\u306b\u6709\u52b9\u306a\u85ac\u5264\u306e\u958b\u767a\u306b\u7e4b\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001Lon\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306f\u69d8\u3005\u306a\u5916\u90e8\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3057\u3066\u50cd\u3044\u3066\u3044\u308b\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u3001\u305d\u306e\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3068\u8001\u5316\u3068\u306e\u95a2\u308f\u308a\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u5206\u5b50\u3068\u3057\u3066\u306eCRBN\u306b\u7740\u76ee\u3057\u3001CRBN\u3092\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u305d\u306e\u6fc3\u5ea6\u3092\u8a08\u6e2c\u3067\u304d\u308c\u3070\u3001\u30b9\u30c8\u30ec\u30b9\u3084\u8001\u5316\u306e\u6307\u6a19\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u6210\u679c\u306f\u3001\u82f1\u56fdNature Publishing Group\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u79d1\u5b66\u96d1\u8a8c\u300eScientific Reports\u300f\u306b\u3001\uff17\u670815\u65e510\u6642\uff08\u65e5\u672c\u6642\u9593\uff17\u670815\u65e518\u6642\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u63b2\u8f09\u8ad6\u6587\uff1a<a class=\"addicn\" href=\"http:\/\/www.nature.com\/articles\/srep29986\" target=\"_blank\">Mitochondrial cereblon functions as a Lon-type protease<\/a><\/p>\n<p>\u307e\u305f\u3001\u672c\u7814\u7a76\u306f\u65e9\u7a32\u7530\u5927\u5b66\u304c\u30b5\u30c6\u30e9\u30a4\u30c8\u3068\u3057\u3066\u5c55\u958b\u3057\u3066\u3044\u308b\u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb\uff08JST\uff09\u304c\u63a8\u9032\u3059\u308b\u30bb\u30f3\u30bf\u30fc\u30fb\u30aa\u30d6\u30fb\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\uff08COI\uff09\u30d7\u30ed\u30b0\u30e9\u30e0\u306e<a class=\"addicn\" href=\"http:\/\/www.jst.go.jp\/coi\/site\/vision\/vision01_3.html\" target=\"_blank\">\u300c\u3055\u308a\u3052\u306a\u3044\u30bb\u30f3\u30b7\u30f3\u30b0\u3068\u65e5\u5e38\u4eba\u9593\u30c9\u30c3\u30af\u3067\u5b9f\u73fe\u3059\u308b\u7406\u60f3\u81ea\u5df1\u3068\u5bb6\u65cf\u306e\u7d46\u304c\u5c0e\u304f\u30e2\u30c1\u30d9\u30fc\u30b7\u30e7\u30f3\u5411\u4e0a\u793e\u4f1a\u5275\u751f\u62e0\u70b9\u300d<\/a>\u3067\u5f97\u3089\u308c\u305f\u7814\u7a76\u6210\u679c\u3067\u3059\u3002<\/p>\n<p>\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u306f<a href=\"https:\/\/www.waseda.jp\/top\/news\/43235\" target=\"_blank\">\u3053\u3061\u3089<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u65e9\u7a32\u7530\u5927\u5b66\u30ca\u30ce\u30fb\u30e9\u30a4\u30d5\u5275\u65b0\u7814\u7a76\u6a5f\u69cb\u306e\u6fa4\u6751\u76f4\u54c9\uff08\u3055\u308f\u3080\u3089\u306a\u304a\u3084\uff09\u4e3b\u4efb\u7814\u7a76\u54e1\uff08\u7814\u7a76\u9662\u51c6\u6559\u6388\uff09\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u7cbe\u795e\u9045\u6ede\u539f\u56e0\u907a\u4f1d\u5b50\u3067\u3042\u308b\u30bb\u30ec\u30d6\u30ed\u30f3\uff08Cereblon\u3001\u4ee5\u4e0bCRBN\uff09\u304c\u3001\u6297\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u7d30\u80de\u4fdd\u8b77\u6a5f\u80fd\u3092\u6301\u3063\u3066\u3044\u308b [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":839,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[28],"class_list":["post-835","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-research","lang-ja"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/inst\/nanolife\/wp-json\/wp\/v2\/posts\/835","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/inst\/nanolife\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/inst\/nanolife\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/nanolife\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/nanolife\/wp-json\/wp\/v2\/comments?post=835"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/inst\/nanolife\/wp-json\/wp\/v2\/posts\/835\/revisions"}],"predecessor-version":[{"id":837,"href":"https:\/\/www.waseda.jp\/inst\/nanolife\/wp-json\/wp\/v2\/posts\/835\/revisions\/837"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/nanolife\/wp-json\/wp\/v2\/media\/839"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/inst\/nanolife\/wp-json\/wp\/v2\/media?parent=835"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/nanolife\/wp-json\/wp\/v2\/categories?post=835"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/inst\/nanolife\/wp-json\/wp\/v2\/tags?post=835"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}