\uff1c\u30bb\u30c3\u30b7\u30e7\u30f31\uff1e \u5ea7\u9577\uff1a\u9ad8\u6728\u4fca \u5148\u751f<\/p>\n
\u30c9\u30d7\u30e9\u8d85\u97f3\u6ce2\u6cd5\u306b\u3088\u308b\u904b\u52d5\u5f8c\u306e\u814e\u8840\u6d41\u306b\u95a2\u3059\u308b\u7814\u7a76\u00a0\uff0f\u4f50\u85e4\u6587\u9999\uff08\u8d64\u9593\u7814\u7a76\u5ba4\uff09<\/p>\n
\u6226\u524d\u65e5\u672c\u306b\u304a\u3051\u308b\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u306e\u6210\u7acb\u3068\u5c55\u958b\u20151920\uff0d30\u5e74\u4ee3\u306e\u30b9\u30dd\u30fc\u30c4\u533b\u5b66\u3068\u52b4\u50cd\u79d1\u5b66\u3092\u4e2d\u5fc3\u3068\u3057\u3066\u2015\u00a0\uff0f\u4f50\u3005\u6728\u9678\u6469\uff08\u77f3\u4e95\u7814\u7a76\u5ba4\uff09<\/p>\n
\u65e5\u4e2d\u7e70\u308a\u8fd4\u3057\u884c\u3046\u4e2d\u5f37\u5ea6\u6709\u9178\u7d20\u904b\u52d5\u304c\u591c\u9593\u7761\u7720\u306b\u4e0e\u3048\u308b\u52b9\u679c\u00a0\uff0f\u7530\u908a\u5f18\u7950\uff08\u5185\u7530\u7814\u7a76\u5ba4\uff09<\/p>\n
\u5c0f\u5b66\u6821\u306b\u304a\u3051\u308b\u59cb\u696d\u524d\u306e\u6642\u9593\u5e2f\u3067\u306e\u5150\u7ae5\u306e\u8eab\u4f53\u6d3b\u52d5\u63a8\u9032\u306b\u95a2\u3059\u308b\u7814\u7a76\u00a0\uff0f\u9ad8\u6a4b\u4eae\u5e73\uff08\u5ca1\u7814\u7a76\u5ba4\uff09<\/p>\n
\u904b\u52d5\u4ecb\u5165\u304c\u88ab\u885d\u6483\u6642\u306e\u981a\u90e8\u7b4b\u53cd\u5fdc\u901f\u5ea6\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u00a0\uff0f\u68b6\u539f\u6176\u88d5\uff08\u91d1\u5ca1\u7814\u7a76\u5ba4\uff09<\/p>\n
\uff1c\u30bb\u30c3\u30b7\u30e7\u30f32\uff1e \u5ea7\u9577\uff1a\u6c60\u6751\u53f8 \u5148\u751f<\/p>\n
\u5bfe\u5074\u624b\u8db3\u3068\u540c\u5074\u624b\u8db3\u306e\u5354\u8abf\u52d5\u4f5c\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306e\u9055\u3044\u306b\u95a2\u9023\u3059\u308b\u8133\u90e8\u4f4d\uff0f\u5ddd\u5cf6\u5f69\u6075\u5b50\uff08\u5f7c\u672b\u7814\u7a76\u5ba4\uff09<\/p>\n
\u9ad8\u5f37\u5ea6\u30da\u30c0\u30ea\u30f3\u30b0\u52d5\u4f5c\u6642\u306e\u8db3\u90e8\u56fa\u5b9a\u306e\u6709\u7121\u304c\u5927\u817f\u90e8\u306e\u7b4b\u7fa4\u306e\u6d3b\u52d5\u304a\u3088\u3073\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306b\u53ca\u307c\u3059\u5f71\u97ff\uff0f\u798f\u7530\u6e09\uff08\u5ddd\u4e0a\u7814\u7a76\u5ba4\uff09<\/p>\n
\u7af6\u6280\u8005\u306b\u304a\u3051\u308b\u57fa\u790e\u4ee3\u8b1d\u91cf\u500b\u4eba\u5dee\u306e\u898f\u5b9a\u8981\u56e0\u306e\u691c\u8a0e\uff0f\u9234\u6728\u6674\u9999\uff08\u7530\u53e3\u7814\u7a76\u5ba4\uff09<\/p>\n
\u9ad8\u7b49\u5b66\u6821\u300c\u4f53\u80b2\u7406\u8ad6\u300d\u9818\u57df\u306b\u304a\u3051\u308b\u6388\u696d\u4f5c\u6210\u306e\u8a66\u307f\u306b\u95a2\u3059\u308b\u7814\u7a76\u2015\u5358\u5143\u300c\u30c8\u30c3\u30d7\u30a2\u30b9\u30ea\u30fc\u30c8\u306e\u6804\u5149\u3068\u6ca1\u843d\u300d\u306e\u4e8b\u4f8b\u3092\u57fa\u306b\u3057\u3066\u2015\uff0f\u677e\u7530\u5e83\uff08\u53cb\u6dfb\u7814\u7a76\u5ba4\uff09<\/p>\n
\u4e2d\u9ad8\u9f62\u7537\u6027\u306b\u304a\u3051\u308b\u98df\u4e8b\u30d1\u30bf\u30fc\u30f3\u3068\u5185\u81d3\u8102\u80aa\u578b\u80a5\u6e80\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\uff0f\u4f0a\u85e4\u667a\u5b50\uff08\u6a0b\u53e3\u7814\u7a76\u5ba4\uff09<\/p>\n
\uff1c\u30bb\u30c3\u30b7\u30e7\u30f33\uff1e \u5ea7\u9577\uff1a\u6c34\u53e3\u66a2\u7ae0 \u5148\u751f<\/p>\n
\u30ab\u30c3\u30c6\u30a3\u30f3\u30b0\u52d5\u4f5c\u306b\u304a\u3051\u308b\u6162\u6027\u8db3\u95a2\u7bc0\u4e0d\u5b89\u5b9a\u75c7\u4f8b\u306e\u4e0b\u80a2\u904b\u52d5\u7279\u6027\u2015\u8db3\u95a2\u7bc0\u5f1b\u7de9\u6027\uff0c\u8db3\u95a2\u7bc0\u5185\u65cb\u3092\u542b\u3081\u305f\u691c\u8a0e\u2015\uff0f\u677f\u82b1\u4fca\u5e0c\uff08\u798f\u6797\u7814\u7a76\u5ba4\uff09<\/p>\n
\u8a8d\u77e5\u5b66\u7fd2\u4e2d\u306e\u4e8b\u8c61\u95a2\u9023\u96fb\u4f4d\uff0f\u5e73\u5c3e\u8cb4\u5927\uff08\u6b63\u6728\u7814\u7a76\u5ba4\uff09<\/p>\n
\u30b7\u30fc\u30ba\u30f3\u30c1\u30b1\u30c3\u30c8\u975e\u7d99\u7d9a\u8cfc\u5165\u306b\u81f3\u308b\u30d7\u30ed\u30bb\u30b9\uff0f\u5742\u8a70\u6b69\u5b50\uff08\u677e\u5ca1\u7814\u7a76\u5ba4\uff09<\/p>\n
\u6b66\u8853\u592a\u6975\u62f3\u306e\u7af6\u6280\u4f1a\u3067\u9ad8\u5f97\u70b9\u3092\u7372\u5f97\u3067\u304d\u308b\u6f14\u6b66\u306e\u904b\u52d5\u5b66\u7684\u7279\u5fb4\uff1a\u300e\u5f13\u6b69\u6c96\u62f3\u300f\u306b\u7740\u76ee\u3057\u3066\uff0f\u7f85\u5289\u661f\uff08\u77e2\u5185\u7814\u7a76\u5ba4\uff09<\/p>\n
\u5c0f\u5b66\u6821\u4e2d\u5b66\u5e74\u306e\u300c\u304b\u3051\u3063\u3053\u30fb\u30ea\u30ec\u30fc\u300d\u306e\u6388\u696d\u306b\u304a\u3051\u308b\u75be\u8d70\u80fd\u529b\u5411\u4e0a\u306e\u305f\u3081\u306e\u6307\u5c0e\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u95a2\u3059\u308b\u7814\u7a76\uff0f\u68b6\u653f\u5fb3\uff08\u5409\u6c38\u7814\u7a76\u5ba4\uff09<\/p>\n
<\/p>\n
\u9aa8\u683c\u7b4b\u5185\u306e\u6027\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u5897\u5927\u306b\u3088\u308b\u65b0\u898f\u7cd6\u5c3f\u75c5\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u5411\u3051\u3066<\/p>\n
\u4f50\u85e4\u5e78\u6cbb\u5148\u751f\uff08\u7acb\u547d\u9928\u5927\u5b66\uff09<\/p>\n
\u7cd6\u5c3f\u75c5\u3084\u80a5\u6e80\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u8840\u4e2d\u304a\u3088\u3073\u9aa8\u683c\u7b4b\u5185\u306e\u6027\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u6fc3\u5ea6\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u6211\u3005\u306f\u3001\u6027\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u306e\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308b\u65b0\u305f\u306a\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u305f\u3002\u73fe\u5728\u307e\u3067\u306b\u52d5\u7269\u5b9f\u9a13\u3067\u57fa\u790e\u7814\u7a76\u3092\u884c\u3044\u3001\u305d\u308c\u3089\u306e\u57fa\u790e\u30c7\u30fc\u30bf\u3092\u57fa\u306b\u3001\u4eca\u5f8c\u3001\u904b\u52d5\u3084\u6804\u990a\u6210\u5206\u6442\u53d6\u306b\u3088\u308b\u6027\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u5897\u5927\u304c\u65b0\u898f\u7cd6\u5c3f\u75c5\u6cbb\u7642\u30fb\u4e88\u9632\u6cd5\u958b\u767a\u306b\u5411\u3051\u3001\u30d2\u30c8\u306b\u5fdc\u7528\u3057\u3066\u3044\u304f\u3002
\n\u307e\u305a\u59cb\u3081\u306b\u3001\u7b4b\u57f9\u990a\u7d30\u80de\u3067\u3001\u7cbe\u5de3\u3084\u5375\u5de3\u3060\u3051\u3067\u306a\u304f\u3001\u7b4b\u306b\u304a\u3044\u3066\u3082\u6027\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u304c\u4ee3\u8b1d\u30fb\u5408\u6210\u3055\u308c\u308b\u3053\u3068\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u5831\u544a\u3057\u3001\u305d\u306e\u6027\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u304c\u9aa8\u683c\u7b4b\u306e\u7cd6\u4ee3\u8b1d\u3092\u4ea2\u9032\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u3002\u52d5\u7269\u5b9f\u9a13\u306b\u304a\u3044\u3066\u3082\u3001\u6025\u6027\u3001\u6162\u6027\u306e\u904b\u52d5\u3067\u9aa8\u683c\u7b4b\u306e\u6027\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u304c\u5897\u52a0\u3057\u3001\u305d\u306e\u5897\u52a0\u3057\u305f\u6027\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u6539\u5584\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u307e\u305f\u30012\u578b\u7cd6\u5c3f\u75c5\u30e2\u30c7\u30eb\u30e9\u30c3\u30c8\u3092\u7528\u3044\u3066\u904b\u52d5\u3001\u904b\u52d5\uff0b\u6027\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u5408\u6210\u963b\u5bb3\u5264\u3092\u6162\u6027\u7684\u306b\u6295\u4e0e\u3057\u305f\u7d50\u679c\u3001\u963b\u5bb3\u5264\u3092\u6295\u4e0e\u3057\u305f2\u578b\u7cd6\u5c3f\u75c5\u30e9\u30c3\u30c8\u306f\u904b\u52d5\u306b\u3088\u308b\u9aa8\u683c\u7b4b\u7cd6\u4ee3\u8b1d\u7d4c\u8def\u3001\u8840\u7cd6\u5024\u306e\u6539\u5584\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u305f\u3002
\n\u30d2\u30c8\u306b\u304a\u3044\u3066\u3001\u9ad8\u9f62\u8005\u3067\u306f\u3001\u6027\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u304c\u3001\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u308a\u9aa8\u683c\u7b4b\u5185\u306e\u6027\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u6fc3\u5ea6\u304c\u5897\u5927\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u6027\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u306e\u5f79\u5272\u3001\u9ad8\u9f62\u8005\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6027\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u5897\u5927\u306e\u610f\u7fa9\u306b\u3064\u3044\u3066\u7d39\u4ecb\u3059\u308b\u4e88\u5b9a\u3067\u3042\u308b\u3002<\/p>\n
<\/p>\n
\u77e5\u899a\u30fb\u8a8d\u77e5\u306e\u8996\u70b9\u304b\u3089\u904b\u52d5\u5236\u5fa1\u3092\u3068\u3089\u3048\u308b\uff0d\u79fb\u52d5\u884c\u52d5\u3092\u4e2d\u5fc3\u306b\uff0d<\/p>\n
\u6a0b\u53e3\u8cb4\u5e83\u5148\u751f\uff08\u9996\u90fd\u5927\u5b66\u6771\u4eac\uff09<\/p>\n
\u30b9\u30dd\u30fc\u30c4\u52d5\u4f5c\u3084\u65e5\u5e38\u52d5\u4f5c\u306e\u5236\u5fa1\u306e\u4ed5\u7d44\u307f\u3092\u8003\u3048\u308b\u6642\uff0c\u89e3\u5256\u5b66\u30fb\u904b\u52d5\u751f\u7406\u5b66\u30fb\u904b\u52d5\u529b\u5b66\u3068\u3044\u3063\u305f\uff0c\u904b\u52d5\u306e\u51fa\u529b\u306b\u95a2\u308f\u308b\u77e5\u8b58\u4f53\u7cfb\u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3053\u3068\u306f\u8a00\u3046\u307e\u3067\u3082\u306a\u3044\u3002\u672c\u8b1b\u6f14\u3067\u306f\uff0c\u77e5\u899a\u3084\u8a8d\u77e5\u306b\u95a2\u308f\u308b\u77e5\u8b58\u4f53\u7cfb\u304c\uff0c\u3053\u3046\u3057\u305f\u77e5\u8b58\u4f53\u7cfb\u3068\u7b49\u3057\u304f\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\uff0c\u6b69\u884c\u3084\u8d70\u884c\u3068\u3044\u3063\u305f\u79fb\u52d5\u884c\u52d5\u306b\u95a2\u3059\u308b\u7814\u7a76\u6210\u679c\u306b\u57fa\u3065\u304d\u6982\u8aac\u3057\u305f\u3044\u3002\u8eab\u4f53\u904b\u52d5\u305d\u308c\u81ea\u4f53\u306f\uff0c\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u53f8\u4ee4\u306b\u57fa\u3065\u304f\u7b4b\u9aa8\u683c\u7cfb\u306e\u632f\u308b\u821e\u3044\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3060\u304b\u3089\u3068\u3044\u3063\u3066\uff0c\u7b4b\u9aa8\u683c\u7cfb\u304c\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u96b7\u5c5e\u7684\u3068\u3044\u3046\u95a2\u4fc2\u3067\u306f\u306a\u3044\u3002\u6b69\u884c\u3067\u306f\uff0c\u632f\u308a\u51fa\u3057\u305f\u4e0b\u80a2\u304c\u74b0\u5883\u306b\u4f5c\u7528\u3059\u308b\u3053\u3068\u3067\uff0c\u69d8\u3005\u306a\u611f\u899a\u60c5\u5831\u304c\u751f\u8d77\u3059\u308b\u3002\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306f\uff0c\u3053\u306e\u611f\u899a\u60c5\u5831\u3092\u53d7\u5bb9\u3059\u308b\u3053\u3068\u3067\u72b6\u6cc1\u3092\u628a\u63e1\u3057\uff0c\u4e8b\u5f8c\u306e\u53f8\u4ee4\u3092\u5fae\u8abf\u6574\u3059\u308b\u3002\u3053\u306e\u3088\u3046\u306b\u898b\u308c\u3070\uff0c\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u53f8\u4ee4\u3092\u5f62\u4f5c\u308b\u306e\u306f\uff0c\u7b4b\u9aa8\u683c\u7cfb\u3068\u74b0\u5883\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3068\u3044\u3063\u3066\u3082\u904e\u8a00\u3067\u306a\u3044\u5074\u9762\u304c\u3042\u308b\u3002\u300c\u8eab\u4f53\u3068\u74b0\u5883\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u300d\u3068\u3044\u3046\u5de8\u8996\u7684\u306a\u5207\u308a\u53e3\u3067\u3068\u3089\u3048\u308b\u3053\u3068\u306b\u3088\u308a\uff0c\u6b69\u884c\u5236\u5fa1\u306e\u771f\u306e\u5b9f\u614b\u304c\u898b\u3048\u3066\u304f\u308b\u90e8\u5206\u3082\u3042\u308b\u3002 \u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\uff0c\u4e3b\u3068\u3057\u3066\u300c\u79fb\u52d5\u884c\u52d5\u306e\u77e5\u899a\u904b\u52d5\u5236\u5fa1\u300d\u306b\u3064\u3044\u3066\u5b9f\u9a13\u3092\u884c\u3046\u3053\u3068\u306b\u3088\u308a\uff0c\u8eab\u4f53\u3068\u74b0\u5883\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3068\u3057\u3066\u904b\u52d5\u3092\u7406\u89e3\u3059\u308b\u8a66\u307f\u3092\u884c\u3063\u3066\u304d\u305f\u3002\u30e9\u30b0\u30d3\u30fc\u9078\u624b\u3084\u30a2\u30e1\u30ea\u30ab\u30f3\u30d5\u30c3\u30c8\u30dc\u30fc\u30eb\u306e\u9078\u624b\u304c\u5bc6\u96c6\u3092\u7a81\u7834\u3059\u308b\u5834\u9762\u306e\u3088\u3046\u306b\uff0c\u72ed\u3044\u9699\u9593\u3092\u5de7\u307f\u306b\u3059\u308a\u629c\u3051\u308b\u884c\u70ba\u306b\u7740\u76ee\u3057\uff0c\u8eab\u4f53\u3068\u74b0\u5883\u306e\u7a7a\u9593\u95a2\u4fc2\u304c\u3069\u306e\u3088\u3046\u306b\u77e5\u899a\u3055\u308c\uff0c\u884c\u52d5\u304c\u8abf\u6574\u3055\u308c\u308b\u306e\u304b\u3092\u691c\u8a0e\u3057\u3066\u304d\u305f\u3002\u672c\u8b1b\u6f14\u3067\u306f\u4e3b\u3068\u3057\u3066\u305d\u306e\u6210\u679c\u3092\u7d39\u4ecb\u3059\u308b\u3002\u3053\u306e\u307b\u304b\uff0c\u4eba\u9593\u306e\u512a\u308c\u305f\u77e5\u899a\u904b\u52d5\u5236\u5fa1\u80fd\u529b\u306b\u95a2\u3059\u308b\u65b0\u3057\u3044\u77e5\u898b\u3068\u3057\u3066\uff0c\u305f\u3063\u305f\u6570\u56de\u306e\u30d0\u30a6\u30f3\u30c9\u97f3\u304c\u3082\u305f\u3089\u3059\u8074\u899a\u60c5\u5831\u3060\u3051\u3067\u30dc\u30fc\u30eb\u306e\u8ecc\u9053\u3092\u4e88\u6e2c\u3057\u3066\uff0c\u30e9\u30b1\u30c3\u30c8\u6b63\u78ba\u306b\u6253\u3061\u8fd4\u3059\u3068\u3044\u3046\u30d6\u30e9\u30a4\u30f3\u30c9\u30c6\u30cb\u30b9\u9078\u624b\u306b\u7740\u76ee\u3057\uff0c\u305d\u306e\u512a\u308c\u305f\u7a7a\u9593\u5b9a\u4f4d\u306b\u95a2\u3059\u308b\u691c\u8a0e\u3092\u304a\u3053\u306a\u3063\u305f\u3002\u672c\u8b1b\u6f14\u3067\u306f\u305d\u306e\u6210\u679c\u306b\u3064\u3044\u3066\u3082\u7d39\u4ecb\u3059\u308b\u3002<\/p>\n
Eccentric exercise: Positive and Negative Aspects<\/p>\n
Professor Kazunori Nosaka\uff08Edith Cowan University, Australia\uff09<\/p>\n
In exercises such as downhill walking, going down stairs, downhill running, Nordic hamstrings exercise and back squat exercise with a heavy weight, leg muscles are stretched or lengthened during submaximal or maximal contractions, which is referred to as eccentric contractions. It has been well documented that unaccustomed exercise consisting of eccentric contractions induces muscle damage characterised by delayed onset muscle soreness and a prolonged decrease in muscle strength. Damage and inflammation of muscle fibres and connective tissue surrounding muscle fibres appear to be associated with these symptoms. When the same eccentric exercise is repeated, less muscle soreness and faster recovery of muscle strength are evident. This adaptation is referred to as the repeated bout effect. It has been shown that submaximal eccentric contractions or maximal isometric contractions at a long muscle length confer protective effect again muscle damage induced by maximal eccentric contractions that are performed within 2 weeks. This type of protective effect is considered as pre-conditioning effect. If eccentric exercise is performed regularly and repeatedly for several weeks, training effects such as increases in muscle strength and size are produced, and these effects of eccentric training have been shown to be greater that those after concentric training in which muscles are shortened. Additionally, eccentric training seems to be more effective than concentric training for improving insulin sensitivity, blood lipid profiles, blood pressure and life-related fitness in elderly individuals. It does not appear that muscle damage is responsible for these adaptations, but eccentric contractions themselves seem to provide potent stimulus for these. The presentation will cover these aspects of eccentric exercise, and discuss positive and negative aspects of eccentric exercise and eccentric exercise training.<\/p>\n
\u767a\u75c7\u5f8c\u65e9\u671f\u306e\u5fc3\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u904b\u52d5\u6642\u9aa8\u683c\u7b4b\u9178\u7d20\u52d5\u614b\u3068\u6700\u9ad8\u9178\u7d20\u6442\u53d6\u91cf<\/p>\n
\u9ad8\u6728\u4fca\u5148\u751f \uff08\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u5b66\u8853\u9662\u52a9\u624b\uff09<\/p>\n
\u6162\u6027\u5fc3\u75be\u60a3\u60a3\u8005(CHF)\u3067\u306f\uff0c\u5de6\u5ba4\u99c6\u51fa\u7387\u3092\u4ee3\u8868\u3068\u3059\u308b\u5fc3\u6a5f\u80fd\u306e\u30dd\u30f3\u30d7\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3002\u305d\u306e\u4e00\u65b9\u3067\uff0c\u904b\u52d5\u4e2d\u306b\u304a\u3051\u308b\u6d3b\u52d5\u7b4b\u3078\u306e\u8840\u6d41\u4f4e\u4e0b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5bc6\u5ea6\u304a\u3088\u3073\u6a5f\u80fd\u4f4e\u4e0b\u306b\u7531\u6765\u3059\u308b\u9aa8\u683c\u7b4b\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u7570\u5e38\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002CHF\u306b\u304a\u3044\u3066\u306f\u6700\u9ad8\u9178\u7d20\u6442\u53d6\u91cf(VO2peak) \u304c\u751f\u547d\u4e88\u5f8c\u306e\u91cd\u8981\u306a\u6c7a\u5b9a\u56e0\u5b50\u3067\u3042\u308b\u304c\uff0cCHF\u306b\u304a\u3051\u308bVO2peak\u306e\u6539\u5584\u306f\uff0c\u5fc3\u6a5f\u80fd\u306e\u6539\u5584\u3068\u306f\u95a2\u9023\u3057\u306a\u3044\u4e00\u65b9\u3067\uff0c\u9aa8\u683c\u7b4b\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u6539\u5584\u3068\u95a2\u9023\u3059\u308b\u3002\u307e\u305f\uff0c\u5fc3\u75be\u60a3\u306e\u7f79\u60a3\u671f\u9593\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304b\u3089\u5fc3\u75be\u60a3\u767a\u75c7\u5f8c\u65e9\u671f\u304b\u3089\u306eVO2peak\u306e\u7dad\u6301\u306a\u3044\u3057\u6539\u5584\u306e\u305f\u3081\u306b\u672b\u68a2\u9aa8\u683c\u7b4b\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u7570\u5e38\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u767a\u75c7\u5f8c\u65e9\u671f\u306b\u304a\u3051\u308b\u5fc3\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u9aa8\u683c\u7b4b\u6a5f\u80fd\u306b\u3064\u3044\u3066\u306f\u5341\u5206\u306b\u691c\u8a0e\u304c\u306a\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u6211\u3005\u306f\uff0c\u8fd1\u8d64\u5916\u5206\u5149\u6cd5\u3092\u7528\u3044\u3066\u767a\u75c7\u5f8c\u65e9\u671f\u306e\u5fc3\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u904b\u52d5\u6642\u9aa8\u683c\u7b4b\u306e\u9178\u7d20\u52d5\u614b\u3068\u5168\u8eab\u6301\u4e45\u529b\u3068\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3057\u3066\u304d\u305f\u3002\u672c\u7814\u7a76\u4f1a\u3067\u306f\uff0c\u767a\u75c7\u5f8c\u65e9\u671f\u306e\u5fc3\u7b4b\u6897\u585e\u5f8c\u60a3\u8005\u306b\u304a\u3051\u308b\u9aa8\u683c\u7b4b\u9178\u7d20\u52d5\u614b\u306b\u95a2\u3059\u308b\u77e5\u898b\u3092\u7d39\u4ecb\u3059\u308b\u4e88\u5b9a\u3067\u3042\u308b\u3002<\/p>\n
\u52a0\u9f62\u306b\u4f34\u3046\u9aa8\u683c\u7b4b\u91cf\u4f4e\u4e0b\uff08\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\uff09\u8a55\u4fa1\u306e\u6700\u524d\u7dda\u2015\u7b4b\u7d30\u80de\u819c\u306e\u96fb\u6c17\u7279\u6027\u3092\u5229\u7528\u3057\u305f\u7b4b\u7d30\u80de\u91cf\u8a55\u4fa1\u6cd5\u2015<\/p>\n
\u5c71\u7530\u967d\u4ecb\u5148\u751f \uff08\u72ec\u7acb\u884c\u653f\u6cd5\u4eba\u56fd\u7acb\u5065\u5eb7\u30fb\u6804\u990a\u7814\u7a76\u6240\uff09<\/p>\n
\u30d2\u30c8\u306e\u9aa8\u683c\u7b4b\u91cf\u3092\u975e\u4fb5\u8972\u7684\u306b\u5b9a\u91cf\u3059\u308b\u65b9\u6cd5\u306f\u5b58\u5728\u3057\u306a\u3044\u305f\u3081\u3001\u3042\u3089\u3086\u308b\u8a55\u4fa1\u6cd5\u306f\u9593\u63a5\u6cd5\u3067\u3042\u308a\u3001\u305d\u308c\u305e\u308c\u9577\u6240\u3084\u77ed\u6240\u304c\u5b58\u5728\u3059\u308b\u3002\u9aa8\u683c\u7b4b\u91cf\u3068\u8eab\u4f53\u6a5f\u80fd\u4f4e\u4e0b\u3084\u7dcf\u6b7b\u4ea1\u30ea\u30b9\u30af\u3068\u306e\u95a2\u4fc2\u3092\u8abf\u3079\u305f\u7814\u7a76\u3092\u30ec\u30d3\u30e5\u30fc\u3059\u308b\u3068CT\u3084DXA\u306a\u3069\u306e\u63a8\u5b9a\u6cd5\u3067\u6c42\u3081\u305f\u7b4b\u91cf\u6307\u6a19\u306f\u3001\u3053\u308c\u3089\u3068\u4e2d\u7a0b\u5ea6\u304b\u5f31\u3044\u95a2\u9023\u3057\u304b\u8a8d\u3081\u3089\u308c\u306a\u3044\u3002DXA\u3067\u306f\u305d\u306e\u539f\u7406\u306b\u57fa\u3065\u304f\u3068\u4f53\u80a2\u9664\u8102\u80aa\u91cf\u3092\u8a08\u6e2c\u3059\u308b\u88c5\u7f6e\u3067\u3042\u308a\u3001\u6b63\u5f0f\u306b\u306f\u9aa8\u683c\u7b4b\u91cf\u3092\u8a08\u6e2c\u3059\u308b\u65b9\u6cd5\u3067\u306f\u306a\u304f\u3001\u7b4b\u91cf\u5909\u5316\u8a55\u4fa1\u306e\u611f\u5ea6\u304c\u4f4e\u3044\u3002MRI\u3067\u63a8\u5b9a\u3055\u308c\u308b\u9aa8\u683c\u7b4b\u91cf\u306f20\u4ee3\u304b\u308970\u4ee3\u3067\u7d0426%\u306e\u4f4e\u4e0b\u3092\u793a\u3059\u3002\u5c4d\u4f53\u89e3\u5256\u306b\u304a\u3044\u3066\u3082\u300120\u4ee3\u306870\u4ee3\u3068\u306e\u9593\u306e\u7b4b\u65ad\u9762\u7a4d\u306e\u4f4e\u4e0b\u7387\u306f26%\u3067\u3042\u308b\u304c\u3001\u7b4b\u7dda\u7dad\u6570\u306f41%\u6e1b\u5c11\u3057\u3066\u304a\u308a\u3001\u7b4b\u7dda\u7dad1\u672c\u3042\u305f\u308a\u306e\u5e73\u5747\u65ad\u9762\u7a4d\u306f11%\u6e1b\u5c11\u3057\u3066\u3044\u308b\u3002\u305d\u306e\u305f\u3081\u3001\u7b4b\u7dda\u7dad\u6570\u00d71\u672c\u3042\u305f\u308a\u306e\u5e73\u5747\u65ad\u9762\u7a4d\u306b\u3088\u3063\u3066\u6c42\u3081\u3089\u308c\u308b\u7dcf\u7b4b\u7dda\u7dad\u65ad\u9762\u7a4d\u306f48%\u306e\u6e1b\u5c11\u3068\u306a\u308b\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u8001\u5316\u306b\u4f34\u3046\u9aa8\u683c\u7b4b\u91cf\u306e\u4f4e\u4e0b\u7387\u3068\u3001\u9aa8\u683c\u7b4b\u7d30\u80de\u91cf\u306e\u4f4e\u4e0b\u7387\u306f\u7570\u306a\u308a\u3001\u7d30\u80de\u9593\u9699\u306e\u5897\u5927\u3092\u6b63\u3057\u304f\u8a55\u4fa1\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u7d30\u80de\u9593\u9699\u306b\u306f\u7d50\u5408\u7d44\u7e54\u3001\u7b4b\u5185\u7d30\u80de\u5916\u8102\u80aa\u3001\u305d\u3057\u3066\u7d30\u80de\u5916\u6db2\u304c\u542b\u307e\u308c\u308b\u3002MRI\u3084CT\u3001DXA\u306a\u3069\u306e\u753b\u50cf\u6cd5\u3067\u306f\u3001\u3053\u306e\u7d30\u80de\u9593\u9699\u90e8\u5206\u304c\u8a55\u4fa1\u3067\u304d\u306a\u3044\u306e\u304c\u554f\u984c\u3067\u3042\u308a\u3001\u771f\u306e\u7b4b\u7d30\u80de\u91cf\u3092\u904e\u5927\u8a55\u4fa1\u3057\u3066\u3057\u307e\u3046\u3053\u3068\u306b\u306a\u308b\u3002\u3064\u307e\u308a\u3001\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u8a55\u4fa1\u306b\u306f\u9aa8\u683c\u7b4b\u91cf\u3067\u306f\u306a\u304f\u3001\u9aa8\u683c\u7b4b\u7d30\u80de\u91cf\u3092\u63a8\u5b9a\u3059\u308b\u5fc5\u8981\u304c\u793a\u5506\u3055\u308c\u308b\u3002\u91cd\u6c34\u7d20\u6a19\u8b58\u30af\u30ec\u30a2\u30c1\u30f3\u5e0c\u91c8\u6cd5\u3084\u751f\u4f53\u96fb\u6c17\u30a4\u30f3\u30d4\u30fc\u30c0\u30f3\u30b9\u5206\u5149\uff08BIS\uff09\u6cd5\u3068\u3044\u3063\u305f\u65b0\u3057\u3044\u65b9\u6cd5\u304c\u958b\u767a\u3055\u308c\u3064\u3064\u3042\u308a\u3001\u4eca\u5f8c\u306e\u5c55\u958b\u306b\u671f\u5f85\u304c\u3067\u304d\u308b\u3002<\/p>\n
Too Much Sitting: Implications for Chronic Disease Prevention<\/p>\n
Prof. Neville Owen \uff08Baker IDI Heart and Diabetes Institute, Australia\uff09<\/p>\n
Exercise is highly beneficial for cardio-metabolic health and other chronic disease outcomes. However, The Lancet\u2019s 2012 Physical Activity Series concluded that the wide-ranging potential health benefits of participation in moderate-to-vigorous physical activity (particularly reducing the risk of type II diabetes, cardiovascular disease and some cancers) remain largely unrealised. Furthermore, even among those who meet the current public health recommendations \u2013 for adults, 30 minutes of moderate-to-vigorous physical activity on most days each week; for children and youth, it is 60 minutes daily \u2013 there are likely to be deleterious health consequences of the 7 to 10 hours of sitting that they are exposed to each day. This talk will provide an overview of the evidence on too much sitting and health outcomes; describe new approaches and findings from objective measurement studies; consider implications of new evidence on the breaking up and patterning of sitting time; report findings from laboratory studies at Baker IDI that aim to understand mechanisms and dose response issues; review evidence on the likely environmental and other determinants of prolonged sitting time; and, highlight recent findings from real-world intervention trials examining the feasibility and potential benefits of reducing sitting time. Directions for future research and likely implications for chronic disease prevention will be discussed.<\/p>\n
\u904b\u52d5\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306e\u30d0\u30e9\u30c4\u30ad\u3092\u751f\u307f\u51fa\u3059\u795e\u7d4c\u6a5f\u69cb<\/p>\n
\u6c34\u53e3\u3000\u66a2\u7ae0\u3000\u5148\u751f\uff08\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u5b66\u8853\u9662\u52a9\u624b\uff09<\/p>\n
\u4eba\u9593\u304c\u540c\u3058\u904b\u52d5\u3092\u884c\u304a\u3046\u3068\u3057\u3066\u3082\u3001\u6bce\u56de\u4e00\u5b9a\u306a\u52d5\u4f5c\u3092\u884c\u3046\u3053\u3068\u306f\u3067\u304d\u305a\u3001\u30d0\u30e9\u30c4\u30ad\u304c\u751f\u3058\u308b\u3002\u30b9\u30dd\u30fc\u30c4\u3067\u306f\u3001\u3053\u306e\u30d0\u30e9\u30c4\u30ad\u3084\u30df\u30b9\u304c\u8a66\u5408\u306e\u7d50\u679c\u3092\u5de6\u53f3\u3059\u308b\u3002\u6211\u3005\u306f\u3001\u904b\u52d5\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306e\u30d0\u30e9\u30c4\u30ad\u3092\u751f\u3058\u3055\u305b\u308b\u539f\u56e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u3001\u307e\u305a\u3001\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306e\u826f\u3057\u60aa\u3057\u3068\u95a2\u9023\u3059\u308b\u8133\u6d3b\u52d5\u3092\u8abf\u3079\u305f\u3002\u3088\u304f\u8a13\u7df4\u3055\u308c\u305f\u7cfb\u5217\u6307\u30bf\u30c3\u30d4\u30f3\u30b0\u8ab2\u984c\u3092\u5bfe\u8c61\u306b\u3001\u8ab2\u984c\u9042\u884c\u4e2d\u306e\u8133\u6d3b\u52d5\u3092\u6a5f\u80fd\u7684\u78c1\u6c17\u5171\u9cf4\u753b\u50cf\u6cd5\u306b\u3066\u8a08\u6e2c\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30bf\u30c3\u30d4\u30f3\u30b0\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u304c\u60aa\u3044\u6642\u306b\u524d\u982d-\u982d\u9802\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u6d3b\u52d5\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002\u6b21\u306b\u3001\u56e0\u679c\u95a2\u4fc2\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001\u524d\u982d-\u982d\u9802\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u6d3b\u52d5\u3092\u4eba\u5de5\u7684\u306b\u9ad8\u3081\u308b\u7d4c\u982d\u84cb\u76f4\u6d41\u96fb\u6c17\u304c\u30bf\u30c3\u30d4\u30f3\u30b0\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u60aa\u5316\u3055\u305b\u308b\u304b\u3092\u8abf\u3079\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u524d\u982d-\u982d\u9802\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u6d3b\u52d5\u3092\u9ad8\u3081\u308b\u3068\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u304c\u60aa\u5316\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u524d\u982d-\u982d\u9802\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u904e\u6d3b\u52d5\u304c\u3088\u304f\u8a13\u7df4\u3055\u308c\u305f\u904b\u52d5\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306e\u30d0\u30e9\u30c4\u30ad\u3092\u751f\u307f\u51fa\u3059\u4e00\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002<\/p>\n
\u8907\u6570\u80a2\u5354\u8abf\u904b\u52d5\u306b\u304a\u3051\u308b\u81ea\u7531\u5ea6\u306e\u5236\u7d04\u3068\u305d\u306e\u767a\u73fe\u8981\u56e0<\/p>\n
\u4e2d\u5ddd \u5263\u4eba \u5148\u751f\uff08\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u5b66\u8853\u9662\u7814\u7a76\u52a9\u624b\uff09<\/p>\n
\u30d2\u30c8\u306f\u591a\u80a2\u3001\u591a\u95a2\u7bc0\u3092\u540c\u6642\u306b\u5354\u8abf\u3055\u305b\u308b\u3053\u3068\u3067\u65e5\u5e38\u751f\u6d3b\u3084\u30b9\u30dd\u30fc\u30c4\u3067\u306e\u591a\u69d8\u306a\u52d5\u4f5c\u3092\u5b9f\u73fe\u3057\u3066\u3044\u308b\u3002\u6b69\u884c\u306e\u3088\u3046\u306a\u81ea\u52d5\u5316\u3055\u308c\u305f\u904b\u52d5\u3067\u306f\u610f\u8b58\u3059\u308b\u3053\u3068\u306f\u306a\u3044\u304c\u3001\u81ea\u52d5\u5316\u3055\u308c\u3066\u3044\u306a\u3044\u5354\u8abf\u904b\u52d5\u3092\u884c\u304a\u3046\u3068\u3059\u308b\u3068\u3001\u69d8\u3005\u306a\u300c\u52d5\u4f5c\u4e0a\u306e\u5236\u7d04\u300d\u304c\u898b\u3089\u308c\u308b\u3002\u4f8b\u3048\u3070\u3001\u540c\u6642\u306b\u540c\u5074\u306e\u624b\u95a2\u7bc0\u3068\u8db3\u95a2\u7bc0\u3092\u5f8b\u52d5\u7684\u306b\u52d5\u304b\u305d\u3046\u3068\u3059\u308b\u3068\u3001\u540c\u65b9\u5411\u306b\u52d5\u304b\u3059\u5834\u5408\u306f\u5b89\u5b9a\u3059\u308b\u304c\u3001\u9006\u65b9\u5411\u306b\u52d5\u304b\u3059\u3068\u304d\u306f\u52d5\u4f5c\u304c\u975e\u5e38\u306b\u4e0d\u5b89\u5b9a\u3067\u3001\u540c\u65b9\u5411\u306b\u8ee2\u79fb\u3057\u3084\u3059\u3044\u3002\u3053\u306e\u3088\u3046\u306a\u73fe\u8c61\u306f\u3001\u8907\u6570\u80a2\u5354\u8abf\u904b\u52d5\u306e\u5236\u5fa1\u304c\u4e00\u80a2\u305a\u3064\u306e\u5236\u5fa1\u3092\u5358\u7d14\u306b\u8db3\u3057\u5408\u308f\u305b\u305f\u3082\u306e\u3067\u306f\u306a\u3044\u3053\u3068\u3092\u793a\u3059\u3002\u30b9\u30dd\u30fc\u30c4\u3084\u697d\u5668\u6f14\u594f\u7b49\u3067\u306f\u3001\u3053\u306e\u3088\u3046\u306a\u5236\u7d04\u306b\u6253\u3061\u52dd\u3063\u3066\u3001\u56db\u80a2\u3092\u52d5\u304b\u3055\u306d\u3070\u306a\u3089\u306a\u3044\u5834\u5408\u304c\u591a\u3044\u3002\u8907\u6570\u80a2\u5354\u8abf\u904b\u52d5\u306e\u5236\u5fa1\u6a5f\u69cb\u306b\u3064\u3044\u3066\u306f\u3001\u4e21\u624b\u5354\u8abf\u904b\u52d5\u3067\u306f\u6bd4\u8f03\u7684\u7814\u7a76\u304c\u306a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u65e5\u5e38\u751f\u6d3b\u3084\u30b9\u30dd\u30fc\u30c4\u52d5\u4f5c\u3067\u3082\u591a\u304f\u898b\u3089\u308c\u308b\u4e0a\u80a2\u3068\u4e0b\u80a2\u306e\u5354\u8abf\u904b\u52d5\u306e\u969b\u306b\u3001\u3069\u306e\u3088\u3046\u306a\u795e\u7d4c\u57fa\u76e4\u304c\u50cd\u3044\u3066\u3044\u308b\u306e\u304b\u3001\u5148\u884c\u7814\u7a76\u304c\u5c11\u306a\u304f\u3001\u4e0d\u660e\u306a\u70b9\u304c\u591a\u3044\u3002\u672c\u7814\u7a76\u4f1a\u3067\u306f\u3001\u4e3b\u306b\u4e0a\u80a2\u3068\u4e0b\u80a2\u3092\u7528\u3044\u305f\u5354\u8abf\u904b\u52d5\u306b\u304a\u3051\u308b\u3001\u9006\u4f4d\u76f8\u52d5\u4f5c\u304c\u4e0d\u5b89\u5b9a\u3067\u540c\u4f4d\u76f8\u306b\u8ee2\u79fb\u3057\u3084\u3059\u3044\u73fe\u8c61\uff08\u52d5\u4f5c\u65b9\u5411\u306e\u5236\u7d04\uff09\u306e\u767a\u73fe\u8981\u56e0\u306b\u3064\u3044\u3066\u691c\u8a0e\u3057\u305f\u5b9f\u9a13\u306e\u30c7\u30fc\u30bf\u3092\u4e2d\u5fc3\u306b\u3001\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u6210\u679c\u3092\u7d39\u4ecb\u3059\u308b\u3002<\/p>\n
\u9ad8\u8840\u5727\u306b\u304a\u3051\u308b\u904b\u52d5\u6642\u795e\u7d4c\u6027\u5faa\u74b0\u8abf\u7bc0\u7570\u5e38<\/p>\n
\u6c34\u91ce \u6b63\u6a39 \u5148\u751f \uff08The University of Texas Southwestern Medical Center, USA\uff09<\/p>\n
\u9ad8\u8840\u5727\u306f\u3001\u4e16\u754c\u4e2d\u306e\u6210\u4eba\u306e\u7d043\u5206\u306e1\u304c\u7f79\u60a3\u3057\u3066\u3044\u308b\u3068\u63a8\u6e2c\u3055\u308c\u3066\u304a\u308a\uff08WHO\uff09\u3001\u6cbb\u7642\u3068\u4e88\u9632\u304c\u91cd\u8981\u306a\u75be\u60a3\u3067\u3042\u308b\u3002\u9ad8\u8840\u5727\u306e\u6cbb\u7642\u6226\u7565\u306f\u3001\u85ac\u7269\u6cbb\u7642\u3084\u98df\u4e8b\u7642\u6cd5\u306b\u52a0\u3048\u3066\u3001\u904b\u52d5\u7642\u6cd5\u304c\u6709\u52b9\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u904b\u52d5\u7642\u6cd5\u306f\u4e00\u5b9a\u306e\u6cbb\u7642\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u4e00\u65b9\u3001\u9ad8\u8840\u5727\u60a3\u8005\u304c\u904b\u52d5\u3092\u884c\u3046\u969b\u306b\u306f\u3001\u5065\u5e38\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u3001\u904e\u5270\u306a\u5faa\u74b0\u5fdc\u7b54\u304c\u60f9\u8d77\u3055\u308c\u308b\u3068\u3044\u3046\u554f\u984c\u3092\u5b55\u3093\u3067\u3044\u308b\u3002\u3053\u306e\u904e\u5270\u306a\u5fdc\u7b54\u306f\u3001\u904b\u52d5\u5b9f\u65bd\u306e\u5927\u304d\u306a\u969c\u5bb3\u3068\u306a\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u904b\u52d5\u6642\u306b\u304a\u3051\u308b\u81f4\u6b7b\u6027\u4e0d\u6574\u8108\u3084\u8133\u5352\u4e2d\u3092\u5f15\u304d\u8d77\u3053\u3059\u5371\u967a\u6027\u3092\u9ad8\u3081\u308b\u3002\u5b89\u5168\u306b\u904b\u52d5\u7642\u6cd5\u3092\u9042\u884c\u3059\u308b\u305f\u3081\u3082\u3001\u9ad8\u8840\u5727\u60a3\u8005\u306b\u89b3\u5bdf\u3055\u308c\u308b\u5faa\u74b0\u5fdc\u7b54\u7570\u5e38\u306e\u767a\u751f\u6a5f\u5e8f\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u6211\u3005\u304c\u904b\u52d5\u3092\u884c\u3046\u969b\u306b\u306f\u3001\u81ea\u5f8b\u795e\u7d4c\u3092\u4ecb\u3057\u305f\u795e\u7d4c\u6027\u306e\u5faa\u74b0\u8abf\u7bc0\u6a5f\u69cb\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3002\u3068\u308a\u308f\u3051\u3001\u9aa8\u683c\u7b4b\u304b\u3089\u306e\u611f\u899a\u60c5\u5831\u306f\u5faa\u74b0\u4e2d\u67a2\u3092\u4ecb\u3057\u3066\u4ea4\u611f\u795e\u7d4c\u6d3b\u52d5\u3092\u4ea2\u9032\u3055\u305b\u308b\u3002\u3053\u306e\u6d3b\u52d5\u7b4b\u304b\u3089\u306e\u53cd\u5c04\u306f\u3001\u904b\u52d5\u6607\u5727\u53cd\u5c04\u3068\u547c\u3070\u308c\u3001\u5fc3\u62cd\u51fa\u91cf\u3092\u9ad8\u3081\u308b\u3068\u4f34\u306b\u975e\u6d3b\u52d5\u90e8\u4f4d\u3078\u306e\u8840\u6d41\u91cf\u3092\u6e1b\u3089\u3057\u3001\u6d3b\u52d5\u7b4b\u306b\u304a\u3051\u308b\u9178\u7d20\u4f9b\u7d66\u306e\u5897\u52a0\u306b\u5bc4\u4e0e\u3059\u308b\u3002\u305d\u3053\u3067\u3001\u672c\u7814\u7a76\u4f1a\u3067\u306f\u3001\u9ad8\u8840\u5727\u30e2\u30c7\u30eb\u52d5\u7269\u306b\u89b3\u5bdf\u3055\u308c\u308b\u904b\u52d5\u6607\u5727\u53cd\u5c04\u3092\u4ecb\u3057\u305f\u904e\u5270\u306a\u4ea4\u611f\u795e\u7d4c\u5fdc\u7b54\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u6982\u8aac\u3059\u308b\u3002<\/p>\n
\u904b\u52d5\u4e2d\u306e\u773c\u5e95\u8840\u6d41\u306e\u5fdc\u7b54<\/p>\n
\u6c60\u6751 \u53f8 \u5148\u751f \uff08\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u5b66\u8853\u9662\u52a9\u624b\uff09<\/p>\n
\u773c\u5e95\u5faa\u74b0\u306f\u7db2\u819c\u52d5\u8108\u304a\u3088\u3073\u8108\u7d61\u819c\u8840\u7ba1\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u8840\u6db2\u5faa\u74b0\u306e\u3053\u3068\u3092\u6307\u3059\uff0e\u773c\u5e95\u8840\u6d41\u306f\u5149\u3092\u53d7\u5bb9\u3059\u308b\u7db2\u819c\u3078\u6804\u990a\u3059\u308b\u305f\u3081\uff0c\u305d\u306e\u8abf\u7bc0\u306f\u8996\u899a\u306e\u7372\u5f97\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3046\uff0e\u7cd6\u5c3f\u75c5\u6027\u7db2\u819c\u75c7\u306a\u3069\u306e\u773c\u75be\u60a3\u306b\u3088\u308a\uff0c\u773c\u5e95\u8840\u6d41\u304c\u6162\u6027\u7684\u306b\u4f4e\u4e0b\u3059\u308b\u3068\u8996\u899a\u6a5f\u80fd\u306b\u969c\u5bb3\u3092\u304d\u305f\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u52a0\u3048\u3066\u6211\u3005\u306f\uff0c\u5065\u5e38\u8005\u306b\u304a\u3044\u3066\u3082\u547c\u5438\u306e\u64cd\u4f5c\u306b\u3088\u3063\u3066\u773c\u5e95\u8840\u6d41\u3092\u5897\u6e1b\u3055\u305b\u308b\u3068\uff0c\u305d\u308c\u306b\u4f34\u3063\u3066\u8996\u529b\u304c\u4e00\u904e\u6027\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u304a\u308a\uff0c\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\uff0c\u773c\u5e95\u8840\u6d41\u304c\u8996\u899a\u6a5f\u80fd\u306e\u7dad\u6301\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u4f3a\u3048\u308b\uff0e\u7db2\u819c\u306e\u6a5f\u80fd\u3092\u6b63\u5e38\u306b\u4fdd\u3064\u305f\u3081\u306b\u306f\uff0c\u7d044mL\/\u5206\u306e\u773c\u5e95\u8840\u6d41\u304c\u5fc5\u8981\u3067\u3042\u308b\uff0e\u904b\u52d5\u4e2d\u306f\u773c\u5e95\u8840\u6d41\u3092\u7dad\u6301\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u4e00\u65b9\u3067\uff0c\u7d0418L\/\u5206\u3082\u306e\u8840\u6d41\u3092\u9aa8\u683c\u7b4b\u306b\u914d\u5206\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\uff0e\u3059\u306a\u308f\u3061\uff0c\u4e21\u8005\u306b\u304a\u3044\u3066\u7cbe\u7dfb\u306a\u8840\u6d41\u8abf\u7bc0\u304c\u6c42\u3081\u3089\u308c\u308b\uff0e\u3068\u3053\u308d\u304c\uff0c\u904b\u52d5\u6642\u306b\u773c\u5e95\u8840\u6d41\u304c\u4e0a\u624b\u304f\u8abf\u7bc0\u3055\u308c\u3066\u3044\u308b\u306e\u304b\u5426\u304b\u306f\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u306a\u3044\uff0e\u305d\u3053\u3067\u6211\u3005\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\uff0c\u69d8\u3005\u306a\u904b\u52d5\u6761\u4ef6\u3067\u306e\u4e00\u904e\u6027\u306e\u904b\u52d5\u4e2d\u306e\u773c\u5e95\u8840\u6d41\u306e\u5fdc\u7b54\u3092\u691c\u8a0e\u3057\uff0c\u904b\u52d5\u4e2d\uff0c\u773c\u5e95\u8840\u6d41\u306f\u5909\u5316\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\uff0e\u672c\u7814\u7a76\u4f1a\u3067\u306f\u305d\u306e\u7814\u7a76\u6210\u679c\u3092\u7d39\u4ecb\u3059\u308b\uff0e<\/p>\n
\u4f53\u5e79\u30a8\u30af\u30b5\u30b5\u30a4\u30ba\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u52b9\u679c\u301c\u30bf\u30a4\u30d7\u5225\u306e\u691c\u8a0e\u301c<\/p>\n
\u4eca\u4e95 \u539a \u5148\u751f\uff08\u65e9\u7a32\u7530\u5927\u5b66\u30b9\u30dd\u30fc\u30c4\u79d1\u5b66\u5b66\u8853\u9662\u52a9\u624b\uff09<\/p>\n
\u4f53\u5e79\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306f\uff0c\u30b9\u30dd\u30fc\u30c4\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u5411\u4e0a\u3084\u50b7\u5bb3\u4e88\u9632\uff0c\u8170\u75db\u306e\u6cbb\u7642\u3084\u4e88\u9632\uff0c\u8ee2\u5012\u4e88\u9632\uff0c\u59ff\u52e2\u77ef\u6b63\u3084\u30b9\u30bf\u30a4\u30eb\u4fdd\u6301\u306a\u3069\u3092\u76ee\u7684\u3068\u3057\u3066\u30b9\u30dd\u30fc\u30c4\u9078\u624b\u304b\u3089\u4e00\u822c\u4eba\u307e\u3067\u5e45\u5e83\u304f\u5b9f\u65bd\u3055\u308c\u3066\u3044\u308b\uff0e\u4f53\u5e79\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3068\u3057\u3066\u591a\u69d8\u306a\u30a8\u30af\u30b5\u30b5\u30a4\u30ba\u304c\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u304c\uff0c\u4e3b\u306b\u7b4b\u529b\u5411\u4e0a\u3092\u76ee\u7684\u3068\u3057\u305fSit up\u3084Back extension\u306a\u3069\u306e\u52d5\u7684\u306a\u8179\u7b4b\u30fb\u80cc\u7b4b\u904b\u52d5(Conventional exercise\uff1aCE)\u3068\uff0c\u4f53\u5e79\u5b89\u5b9a\u6027\u306e\u5411\u4e0a\u3092\u76ee\u7684\u3068\u3057\u305f\u59ff\u52e2\u4fdd\u6301\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u3042\u308bStabilization exercise(SE)\u306b\u5206\u985e\u3067\u304d\u308b\uff0e\u4f53\u5e79\u30a8\u30af\u30b5\u30b5\u30a4\u30ba\u6642\u306e\u7b4b\u6d3b\u52d5\u3084\u810a\u67f1\u3078\u306e\u8ca0\u8377\u306a\u3069\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u591a\u304f\u5831\u544a\u3055\u308c\u3066\u304a\u308a\uff0c\u4e21\u30a8\u30af\u30b5\u30b5\u30a4\u30ba\u306e\u76f8\u9055\u306f\u660e\u3089\u304b\u306b\u306a\u308a\u3064\u3064\u3042\u308b\uff0e\u3057\u304b\u3057\uff0c\u53cc\u65b9\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u52b9\u679c\u3092\u6bd4\u8f03\u3057\u305f\u7814\u7a76\u306f\u6975\u3081\u3066\u5c11\u306a\u304f\uff0c\u305d\u308c\u305e\u308c\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u52b9\u679c\u306e\u7279\u7570\u6027\u306f\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u306a\u3044\uff0e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u52b9\u679c\u306f\u7279\u7570\u6027\u306e\u539f\u5247\u306b\u5fdc\u3058\u3066\u73fe\u308c\u308b\u3053\u3068\u304b\u3089\uff0c\u76ee\u7684\u306b\u5408\u3063\u305f\u9069\u5207\u306a\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u8a2d\u5b9a\u3059\u308b\u305f\u3081\u306b\u306f\uff0cSE\u3068CE\u305d\u308c\u305e\u308c\u306e\u7279\u7570\u7684\u306a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u52b9\u679c\u306b\u3064\u3044\u3066\u691c\u8a0e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\uff0e\u672c\u7814\u7a76\u4f1a\u3067\u306f\uff0cSE\u3068CE\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u52b9\u679c\u3092\u6bd4\u8f03\u3057\u305f\u4ecb\u5165\u7814\u7a76\u306b\u3064\u3044\u3066\u7d39\u4ecb\u3059\u308b\uff0e<\/p>\n
Muscle phosphatidylethanolamine synthesis maintains sarcoplasmic reticulum integrity to regulate contractile function and insulin sensitivity<\/p>\n
Dr. Katsuhiko Funai\uff08East Carolina University\uff09<\/p>\n
Skeletal muscle insulin resistance is an early and essential defect in the development of type 2 diabetes. Molecular mechanisms responsible for reduction in skeletal muscle insulin-stimulated glucose disposal remain elusive. Previously we implicated that alteration in phospholipid composition at the sarcoplasmic reticulum (SR) may contribute to this process. Here we show that choline\/ethanolamine phosphotransferase-1 (CEPT1), a terminal enzyme in Kennedy pathway\u2019s phosphatidylethanolamine (PE) synthesis, regulates muscle insulin sensitivity. In C2C12 cells, lentivirus-mediated knockdown of CEPT1 resulted in altered SR phospholipid compositions and calcium flux. In mice and in humans, muscle CEPT1 abundance was associated with obesity and inversely correlated with insulin sensitivity. Mice with skeletal muscle-specific knockout of CEPT1 exhibited improved insulin sensitivity measured by glucose and insulin tolerance tests, hyperinsulinemic euglycemic clamp and 2-deoxyglucose uptake in isolated muscles. In CEPT1 deleted muscles, altered SR phospholipid milieu reduced sarco\/endoplasmic reticulum Ca2+ ATPase (SERCA)-dependent calcium uptake. This led to the activation of calcium signaling pathways, a known insulin sensitizer. However, dysregulated muscle SR calcium handling made these mice weak and exercise intolerant. Herein we propose that aberrant lipid flux in muscles can place metabolic stress on SR, an \u201cSR stress\u201d, that could compromise muscle contractile property through its action on membrane phospholipid composition. Diet-induced increase in skeletal muscle CEPT1 protects muscles from developing diet-induced SR stress. Paradoxically, this appears to come at the expense of promoting skeletal muscle insulin resistance.<\/p>\n","protected":false},"excerpt":{"rendered":"
\u7b2c145\u56de\uff08\u4fee\u58eb\u8ad6\u6587\u30b3\u30f3\u30c6\u30b9\u30c8\uff09 2\u67089\u65e5\uff08\u6708\uff0913:00\u3088\u308a\u3000\u6240\u6ca2\u30ad\u30e3\u30f3\u30d1\u30b9 100\u53f7\u9928 5F\u3000\u7b2c\u4e00\u4f1a\u8b70\u5ba4 \u5185\u5bb9 \uff1c\u30bb\u30c3\u30b7\u30e7\u30f31\uff1e \u5ea7\u9577\uff1a\u9ad8\u6728\u4fca \u5148\u751f \u30c9\u30d7\u30e9\u8d85\u97f3\u6ce2\u6cd5\u306b\u3088\u308b\u904b\u52d5\u5f8c\u306e\u814e\u8840\u6d41\u306b\u95a2\u3059\u308b\u7814\u7a76\u00a0\uff0f\u4f50\u85e4\u6587\u9999\uff08\u8d64\u9593\u7814 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[85],"tags":[51],"class_list":["post-40","post","type-post","status-publish","format-standard","hentry","category-other","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.waseda.jp\/fsps\/rcsports\/wp-json\/wp\/v2\/posts\/40","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.waseda.jp\/fsps\/rcsports\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.waseda.jp\/fsps\/rcsports\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/fsps\/rcsports\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.waseda.jp\/fsps\/rcsports\/wp-json\/wp\/v2\/comments?post=40"}],"version-history":[{"count":1,"href":"https:\/\/www.waseda.jp\/fsps\/rcsports\/wp-json\/wp\/v2\/posts\/40\/revisions"}],"predecessor-version":[{"id":2031,"href":"https:\/\/www.waseda.jp\/fsps\/rcsports\/wp-json\/wp\/v2\/posts\/40\/revisions\/2031"}],"wp:attachment":[{"href":"https:\/\/www.waseda.jp\/fsps\/rcsports\/wp-json\/wp\/v2\/media?parent=40"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.waseda.jp\/fsps\/rcsports\/wp-json\/wp\/v2\/categories?post=40"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.waseda.jp\/fsps\/rcsports\/wp-json\/wp\/v2\/tags?post=40"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}