Sulforaphane (SFN) is a newly identified dietary supplement, but only a few human studies have been conducted to reflect the effects of SFN intervention on exercise-induced inflammation and oxidative stress. In this review, we discussed the effects of SFN on exercise-induced inflammation and oxidative stress.<\/p>\n
\u30b9\u30eb\u30d5\u30a9\u30e9\u30d5\u30a1\u30f3\uff08SFN\uff09\u306f\u65b0\u305f\u306b\u767a\u898b\u3055\u308c\u305f\u6804\u990a\u88dc\u52a9\u98df\u54c1\u3067\u3059\u304c\u3001\u904b\u52d5\u8a98\u767a\u6027\u708e\u75c7\u304a\u3088\u3073\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b SFN \u4ecb\u5165\u306e\u52b9\u679c\u3092\u53cd\u6620\u3059\u308b\u4eba\u3092\u5bfe\u8c61\u3068\u3059\u308b\u7814\u7a76\u306f\u308f\u305a\u304b\u3057\u304b\u5b9f\u65bd\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001\u904b\u52d5\u8a98\u767a\u6027\u708e\u75c7\u304a\u3088\u3073\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b SFN \u306e\u52b9\u679c\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u307e\u3057\u305f\u3002<\/p>\n
Regular exercise is crucial for our health, but exercise-induced oxidative stress and inflammation are common phenomena, particularly in high-intensity and endurance activities. Although the body has natural defense mechanisms, chronic oxidative stress can lead to tissue damage and impair recovery. SFN, a bioactive compound derived from cruciferous vegetables, has been recognized for its potent antioxidant and anti-inflammatory properties, particularly through the activation of the Nrf2\/HO-1 pathway.<\/p>\n
\u5b9a\u671f\u7684\u306a\u904b\u52d5\u306f\u5065\u5eb7\u306b\u3068\u3063\u3066\u91cd\u8981\u3067\u3059\u304c\u3001\u904b\u52d5\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u708e\u75c7\u306f\u3001\u7279\u306b\u9ad8\u5f37\u5ea6\u304a\u3088\u3073\u6301\u4e45\u529b\u6027\u904b\u52d5\u3067\u306f\u4e00\u822c\u7684\u306a\u73fe\u8c61\u3067\u3059\u3002\u4eba\u4f53\u306b\u306f\u9632\u5fa1\u6a5f\u69cb\u304c\u5099\u308f\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u6162\u6027\u7684\u306a\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u7d44\u7e54\u306e\u640d\u50b7\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u56de\u5fa9\u3092\u963b\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30a2\u30d6\u30e9\u30ca\u79d1\u306e\u91ce\u83dc\u304b\u3089\u5f97\u3089\u308c\u308b\u751f\u7406\u6d3b\u6027\u5316\u5408\u7269\u3067\u3042\u308bSFN\u306f\u3001\u7279\u306b Nrf2\/HO-1 \u7d4c\u8def\u306e\u6d3b\u6027\u5316\u3092\u901a\u3058\u3066\u3001\u5f37\u529b\u306a\u6297\u9178\u5316\u4f5c\u7528\u3068\u6297\u708e\u75c7\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n
Regular exercise is crucial for our health, but exercise-induced oxidative stress and inflammation are common phenomena, particularly in high-intensity and endurance activities. Although the body has natural defense mechanisms, chronic oxidative stress can lead to tissue damage and impair recovery. SFN, a bioactive compound derived from cruciferous vegetables, has been recognized for its potent antioxidant and anti-inflammatory properties, particularly through the activation of the Nrf2\/HO-1 pathway.<\/p>\n
\u5b9a\u671f\u7684\u306a\u904b\u52d5\u306f\u5065\u5eb7\u306b\u3068\u3063\u3066\u91cd\u8981\u3067\u3059\u304c\u3001\u904b\u52d5\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u708e\u75c7\u306f\u3001\u7279\u306b\u9ad8\u5f37\u5ea6\u304a\u3088\u3073\u6301\u4e45\u529b\u6027\u904b\u52d5\u3067\u306f\u4e00\u822c\u7684\u306a\u73fe\u8c61\u3067\u3059\u3002\u4eba\u4f53\u306b\u306f\u9632\u5fa1\u6a5f\u69cb\u304c\u5099\u308f\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u6162\u6027\u7684\u306a\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u7d44\u7e54\u306e\u640d\u50b7\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u56de\u5fa9\u3092\u963b\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30a2\u30d6\u30e9\u30ca\u79d1\u306e\u91ce\u83dc\u304b\u3089\u5f97\u3089\u308c\u308b\u751f\u7406\u6d3b\u6027\u5316\u5408\u7269\u3067\u3042\u308bSFN\u306f\u3001\u7279\u306b Nrf2\/HO-1 \u7d4c\u8def\u306e\u6d3b\u6027\u5316\u3092\u901a\u3058\u3066\u3001\u5f37\u529b\u306a\u6297\u9178\u5316\u4f5c\u7528\u3068\u6297\u708e\u75c7\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n
Since this review does not involve experimental methodology, it discusses findings from previously published animal and human studies using advanced molecular techniques to evaluate exercise-induced Nrf2\/HO-1 activation, antioxidant enzyme activity, and inflammation markers, related to SFN intervention.<\/p>\n
\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u306b\u306f\u5b9f\u9a13\u7684\u624b\u6cd5\u306f\u542b\u307e\u308c\u3066\u3044\u306a\u3044\u305f\u3081\u3001SFN\u4ecb\u5165\u306b\u95a2\u9023\u3059\u308b\u3001\u904b\u52d5\u8a98\u767a\u6027\u306e Nrf2\/HO-1 \u6d3b\u6027\u5316\u3001\u6297\u9178\u5316\u9175\u7d20\u6d3b\u6027\u304a\u3088\u3073\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u9ad8\u5ea6\u306a\u5206\u5b50\u6280\u8853\u3092\u4f7f\u7528\u3057\u305f\u3001\u4ee5\u524d\u306b\u767a\u8868\u3055\u308c\u305f\u52d5\u7269\u304a\u3088\u3073\u30d2\u30c8\u306e\u7814\u7a76\u306e\u7d50\u679c\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n
This review provides insights into the potential use of SFN as a nutraceutical for athletes or individuals undergoing intense physical training. SFN is one of the most studied phytochemicals among isothiocyanates<\/span> and has shown plenty of health benefits. SFN could be a sustainable intervention to improve exercise endurance capacity and elevate mitochondrial function and cellular antioxidant responses.<\/p>\n \u3053\u306e\u30ec\u30d3\u30e5\u30fc\u306f\u3001\u30a2\u30b9\u30ea\u30fc\u30c8\u3084\u6fc0\u3057\u3044\u8eab\u4f53\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3063\u3066\u3044\u308b\u500b\u4eba\u306e\u305f\u3081\u306e\u6804\u990a\u88dc\u52a9\u98df\u54c1\u3068\u3057\u3066\u306e SFN \u306e\u6f5c\u5728\u7684\u4f7f\u7528\u306b\u3064\u3044\u3066\u306e\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002SFN \u306f isothiocyanates<\/span> \u306e\u4e2d\u3067\u6700\u3082\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u690d\u7269\u5316\u5b66\u7269\u8cea\u306e 1 \u3064\u3067\u3042\u308a\u3001\u591a\u304f\u306e\u5065\u5eb7\u4e0a\u306e\u5229\u70b9\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002SFN \u306f\u3001\u904b\u52d5\u6301\u4e45\u529b\u3092\u5411\u4e0a\u3055\u305b\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u3068\u7d30\u80de\u306e\u6297\u9178\u5316\u53cd\u5fdc\u3092\u9ad8\u3081\u308b\u305f\u3081\u306e\u6301\u7d9a\u53ef\u80fd\u306a\u4ecb\u5165\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n Several randomized control trials with different protocols were reported, but a generally acceptable guideline for the intake of SFN is yet to be declared. In order to gain a precise understanding of optimal dosage, long-term safety, and effectiveness of SFN consumption more preclinical and clinical studies are required. Additionally, the interaction of SFN with other dietary components and its effects on diverse populations requires investigation.<\/p>\n \u7570\u306a\u308b\u30d7\u30ed\u30c8\u30b3\u30eb\u306b\u3088\u308b\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u304c\u3044\u304f\u3064\u304b\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001SFN \u306e\u6442\u53d6\u306b\u95a2\u3059\u308b\u4e00\u822c\u7684\u306b\u53d7\u3051\u5165\u308c\u3089\u308c\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u307e\u3060\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002SFN \u6442\u53d6\u306e\u6700\u9069\u306a\u6295\u4e0e\u91cf\u3001\u9577\u671f\u7684\u306a\u5b89\u5168\u6027\u3001\u6709\u52b9\u6027\u3092\u6b63\u78ba\u306b\u7406\u89e3\u3059\u308b\u306b\u306f\u3001\u3088\u308a\u591a\u304f\u306e\u524d\u81e8\u5e8a\u7814\u7a76\u3068\u81e8\u5e8a\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059\u3002\u3055\u3089\u306b\u3001SFN\u3068\u4ed6\u306e\u98df\u4e8b\u6210\u5206\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304a\u3088\u3073\u3055\u307e\u3056\u307e\u306a\u96c6\u56e3\u306b\u5bfe\u3059\u308b\u305d\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u3082\u8abf\u67fb\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n SFN could be used as a potential therapeutic agent, and considering its health-promoting effects, SFN could be a promising future dietary supplement at the forefront of sports nutrition.<\/p>\n SFN \u306f\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u85ac\u3068\u3057\u3066\u4f7f\u7528\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u5065\u5eb7\u5897\u9032\u52b9\u679c\u3092\u8003\u616e\u3059\u308b\u3068\u3001SFN \u306f\u30b9\u30dd\u30fc\u30c4\u6804\u990a\u5b66\u306e\u6700\u524d\u7dda\u306b\u7acb\u3064\u5c06\u6765\u6709\u671b\u306a\u6804\u990a\u88dc\u52a9\u98df\u54c1\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n \u203b1 SFN: Sulforaphane is a naturally occurring indirect antioxidant<\/p>\n \u203b2 Nrf2: Nuclear factor erythroid 2-related factor 2: A key transcription factor that regulates the expression of antioxidant proteins.<\/p>\n \u203b3 HO-1 (Heme oxygenase-1): An enzyme that provides protection against oxidative stress and inflammation.<\/p>\n \u96d1\u8a8c\u540d\/Journal: International Journal of Molecular Sciences<\/p>\n \u8ad6\u6587\u540d\/Title: The Immunomodulatory Effects of Sulforaphane in Exercise-Induced Inflammation and Oxidative Stress: A Prospective Nutraceutical<\/p>\n \u57f7\u7b46\u8005\u540d\u30fb\u6240\u5c5e\u6a5f\u95a2\u540d\/Authors and Affiliated Organisation:<\/p>\n Ruheea Taskin Ruhee: Research Fellow of Japan Society for the Promotion of Sciences, Tokyo 102-0083, Japan<\/p>\n\uff08\uff15\uff09\u4eca\u5f8c\u306e\u8ab2\u984c\uff0fFuture issues<\/h4>\n
\uff08\uff16\uff09\u7814\u7a76\u8005\u306e\u30b3\u30e1\u30f3\u30c8\uff0fResearcher\u2019s Comment<\/h4>\n
\uff08\uff17\uff09\u7528\u8a9e\u89e3\u8aac\uff0fTerminology<\/h4>\n
\uff08\uff18\uff09\u8ad6\u6587\u60c5\u5831\uff0fJournal Information<\/h4>\n