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研究員 / 折原 芳波

折原 芳波

  • 博士(薬学)
  • 早稲田大学高等研究所 助教

Monthly Spotlight[Monthly Spotlihgt]は研究員にスポットをあて、研究内容とそのビジョンを毎月紹介していくコンテンツです。




2002 東京理科大学薬学部薬学科 卒業
2004 東京工業大学大学院生命理工学研究科 修士課程 修了
2007 昭和大学大学院薬学研究科(国立成育医療研究センター研究所 免疫アレルギー研究部) 博士(薬学)取得
2007-2009 国立成育医療研究センター研究所 流動研究員
2009-2014 マニトバ大学医学部免疫研究部 ポスト・ドクトラル・フェロー
2010-2012 マニトバ州立ヘルスリサーチ ポスドク・フェローシップ
2014-- 早稲田大学高等研究所 助教


  • 免疫神経学
  • アレルギー学
  • 分子生物学
  • 薬学
  • 免疫学
  • 遺伝学
  • 生物統計学
  • 疫学


  • 1. Ilarraza R, Odemuyiwa S.O, Orihara K, Arizmendi N, Moqbel R. Eosinophils as Immunemodulators; Role of Inodleamine 2,3 Dioxygenase (IDO) and Tryptophan Catabolites. In Eosinophils in Health and Disease; 16.4 621-634; Editors: Lee J.J., Rosenberg H.F.; Academic Press, 2012-12-17.
  • 2. Morita H, Nomura I, Orihara K, Yoshida K, Akasawa A, Tachimoto H, Ohtsuka Y, Namai Y, Futamura M, Shoda T, Matsuda A, Kamemura N, Kido H, Takahashi T, Ohya Y, Saito H, Matsumoto K. “Antigen-specific T-cell responses in patients with non-IgE-mediated gastrointestinal food allergy are predominantly skewed to TH2”, J Allergy Clin Immunol. 2012 Oct 16.
  • 3. Yagami A,* Orihara K,* Morita H, Hashimoto N, Futamura K, Matsumoto K, Saito H, Matsuda A. “IL-33 Mediates Inflammatory Responses in Human Lung Tissue Cells”, J Immunol. 2010 Nov 15;185(10):5743-50.
    *A.Y. and K.O.contributed equally to this work.
  • 4. Orihara K, Dil N, Anaparti V, Moqbel R. What’s new in Asthma Pathophysiology and Immunopathology? Expert Rev Respir Med. 2010 Oct;4(5):605-29.
  • 5. Futamura K,* Orihara K,* Hashimoto N, Morita H, Fukuda S, Sagara H, Matsumoto K, Tomita Y, Saito H, Matsuda A. “beta2-adrenoceptor agonists enhance cytokine-induced release of thymic stromal lymphopoietin by lung tissue cells”, Int Arch Allergy Immunol. 2010;152(4):353-61.
    *K.F. and K.O. contributed equally to this work.
  • 6. Matsuda A. Orihara K, Matsumoto K, Saito H. Asthmatic airway remodeling, from the perspective of pulmonary microvascular structure and functions. Kokyu. 2009;28(5):547-549.
  • 7. Enomoto Y, Orihara K, Takazmasu T, Matsuda A, Gon Y, Saito H, Ra C, Okayama Y. “Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack”, J Allergy Clin Immunol. 2009;124(5):913-20.
  • 8. Orihara K, Morita H, Yagami A, Matsumoto K, Nagasaki H, Saito Y, Saito H, Matsuda A. “TH2 cytokines potently induce an appetite-stimulating peptide, melanin-concentrating hormone, in human vascular endothelial cells”, J Allergy Clin Immunol. 2009;124(3):612-4.
  • 9. Orihara K, Matsuda A. Pathophysiolosical roles of microvascular alterations in pulmonary inflammatory diseases: Possible implications of tumor necrosis factor-alpha and CXC chmokines. Int J Chron Obstruct Pulmon Dis. 2008;3(4):619-27.
  • 10. Matsuda A, Orihara K, Fukuda S, Fujinaga H, Matsumoto K, Saito H. “Corticosteroid enhances TNF-alpha-mediated leukocyte adhesion to pulmonary microvascular endothelial cells”, Allergy 2008;63(12):1610-6.
  • 11. Orihara K, Nakae S, Pawankar R, Saito H. Role of regulatory and proinflammatory T cell populations in allergic diseases. World Allergy Organization Journal. 2008 Jan; 1(1):9-14.
  • 12. Orihara K, Narita M, Tobe T, Akasawa A, Matsumoto K, Saito H. “Circulating Foxp3+CD4+ cell number in atopic patients and healthy controls”, J Allergy Clin Immunol. 2007;120(4):960-2.
  • 13. Negoro T, Orihara K, Irahara T, Nishiyama H, Hagiwara K, Nishida R, Takagi H, Satoh K, Yamamoto Y, Shimizu S, Hagiwara T, Ishii M, Tanioka T, Nakano Y, Takeda K, Yoshimura I, Iikura I, Tobe T. “Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children”, Pediatr Allergy Immunol. 2006;17(8):583-90.
  • 14. Orihara K, Yamazaki T, Shinkyo R, Sakaki T, Inouye K, Tsukamoto A, Sugiura, J. Shishido, K. “Rat cytochrome P450-mediated transformation of dichlorodibenzo-p-dioxins by recombinant white-rot basidiomycete Coriolus hirsutus”, Appl Microbiol Biotechnol. 2005;69(1):22-8.


  • 日本アレルギー学会
  • 日本免疫学会
  • American Academy of Allergy, Asthma & Immunology
  • AAAAI Interest Section, Mechanisms of Asthma and Allergic Inflammation
  • Canadian Society of Allergy and Clinical Immunology
  • Canadian Society for Immunology
  • International Eosinophil Society
  • 受賞

    1999 ロンドン国際青少年科学フォーラム 日本代表
    2001 科学技術振興会 奨学生
    2003 ストックホルム国際青年科学セミナー 日本代表
    2004 日本国際賞・ジャパンプライズ週間 学生代表
    2007 Grant-in-Aid for Young Scientists (Category B) from the Japan Society for the Promotion of Science
    2007 Travel Grant from the Asia Pacific Association of Allergy, Asthma and Clinical Immunology
    2010 FIT Travel Scholarship from the American Academy of Allergy, Asthma & Immunology
    2010 Postdoctoral Fellowship from the Manitoba Health Research Council (co-supported by Manitoba Institute of Child Health)
    2010 Travel Grant from the Canadian Society of Allergy and Clinical Immunology
    2011 FIT Travel Scholarship from the American Academy of Allergy, Asthma & Immunology
    2011 1st place poster award (Postdoc category) at the Manitoba Neuroscience Network
    2011 Young Investigator Award from the International Eosinophil Society 7th Biennial Symposium
    2011 Travel Allowance from the Manitoba Health Research Council
    2012 Alain de Weck Travel Grant from the Collegium International Allergologicum
    2013 FIT Travel Scholarship from the American Academy of Allergy, Asthma & Immunology