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Researchers / Kanami Orihara

Kanami Orihara

  • PhD (Pharmacy)
  • Assistant Professor, Waseda Institute for Advanced Study

Research Topics

I am investigating allergies from a new and emerging field of neuroimmunology. In particular, NMDA-R (a type of neurotransmitter receptors) and amphiregulin (an agonist for EGFR and a known growth factor for some type of cancers) are the key factors in this study. With a view to clarify the role of NMDA-R in immune regulation, I am currently aiming to delineate a mechanism of amphiregulin contributes to immune imbalance, leading to chronicity in allergies.

Education and Academic Employment

2002 Pharm.B. Pharmaceutical Sciences, Tokyo University of Science
2004 M.Sc. Bioscience, Tokyo Institute of Technology
2007 Ph.D. Pharmaceutical Sciences, Showa University
2007-2009 Post Doctoral Research Fellow, Department of Allergy and Immunology, National Research Institute for Child Health & Development
2009-2014 Post Doctoral Research Fellow, Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
2010-2012 Post Doctoral Fellowship, Manitoba Health Research Council
2014- Assistant Professor, Waseda Institute for Advance Study, Waseda University

Research Fields of Interest

  • Neuroimmunology
  • Allergy
  • Molecular Biology
  • Pharmacy
  • Immunology
  • Genetics
  • Biostatistics
  • Epidemiology

Academic Publications

  1. Ilarraza R, Odemuyiwa S.O, Orihara K, Arizmendi N, Moqbel R.  Eosinophils as Immunemodulators; Role of Inodleamine 2,3 Dioxygenase (IDO) and Tryptophan Catabolites.  In Eosinophils in Health and Disease; 16.4 621-634; Editors: Lee J.J., Rosenberg H.F.; Academic Press, 2012-12-17.
  2. Morita H, Nomura I, Orihara K, Yoshida K, Akasawa A, Tachimoto H, Ohtsuka Y, Namai Y, Futamura M, Shoda T, Matsuda A, Kamemura N, Kido H, Takahashi T, Ohya Y, Saito H, Matsumoto K. “Antigen-specific T-cell responses in patients with non-IgE-mediated gastrointestinal food allergy are predominantly skewed to TH2”, J Allergy Clin Immunol. 2012 Oct 16.
  3. Yagami A,* Orihara K,* Morita H, Hashimoto N, Futamura K, Matsumoto K, Saito H, Matsuda A. “IL-33 Mediates Inflammatory Responses in Human Lung Tissue Cells”, J Immunol. 2010 Nov 15;185(10):5743-50.
    *A.Y. and K.O.contributed equally to this work.
  4. Orihara K, Dil N, Anaparti V, Moqbel R. What’s new in Asthma Pathophysiology and Immunopathology? Expert Rev Respir Med. 2010 Oct;4(5):605-29.
  5. Futamura K,* Orihara K,* Hashimoto N, Morita H, Fukuda S, Sagara H, Matsumoto K, Tomita Y, Saito H, Matsuda A. “beta2-adrenoceptor agonists enhance cytokine-induced release of thymic stromal lymphopoietin by lung tissue cells”, Int Arch Allergy Immunol. 2010;152(4):353-61.
    *K.F. and K.O. contributed equally to this work.
  6. Matsuda A. Orihara K, Matsumoto K, Saito H. Asthmatic airway remodeling, from the perspective of pulmonary microvascular structure and functions. Kokyu. 2009;28(5):547-549.
  7. Enomoto Y, Orihara K, Takazmasu T, Matsuda A, Gon Y, Saito H, Ra C, Okayama Y. “Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack”, J Allergy Clin Immunol. 2009;124(5):913-20.
  8. Orihara K, Morita H, Yagami A, Matsumoto K, Nagasaki H, Saito Y, Saito H, Matsuda A. “TH2 cytokines potently induce an appetite-stimulating peptide, melanin-concentrating hormone, in human vascular endothelial cells”, J Allergy Clin Immunol. 2009;124(3):612-4.
  9. Orihara K, Matsuda A. Pathophysiolosical roles of microvascular alterations in pulmonary inflammatory diseases: Possible implications of tumor necrosis factor-alpha and CXC chmokines. Int J Chron Obstruct Pulmon Dis. 2008;3(4):619-27.
  10. Matsuda A, Orihara K, Fukuda S, Fujinaga H, Matsumoto K, Saito H. “Corticosteroid enhances TNF-alpha-mediated leukocyte adhesion to pulmonary microvascular endothelial cells”, Allergy 2008;63(12):1610-6.
  11. Orihara K, Nakae S, Pawankar R, Saito H. Role of regulatory and proinflammatory T cell populations in allergic diseases. World Allergy Organization Journal. 2008 Jan; 1(1):9-14.
  12. Orihara K, Narita M, Tobe T, Akasawa A, Matsumoto K, Saito H. “Circulating Foxp3+CD4+ cell number in atopic patients and healthy controls”, J Allergy Clin Immunol. 2007;120(4):960-2.
  13. Negoro T, Orihara K, Irahara T, Nishiyama H, Hagiwara K, Nishida R, Takagi H, Satoh K, Yamamoto Y, Shimizu S, Hagiwara T, Ishii M, Tanioka T, Nakano Y, Takeda K, Yoshimura I, Iikura I, Tobe T. “Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children”, Pediatr Allergy Immunol. 2006;17(8):583-90.
  14. Orihara K, Yamazaki T, Shinkyo R, Sakaki T, Inouye K, Tsukamoto A, Sugiura, J. Shishido, K.  “Rat cytochrome P450-mediated transformation of dichlorodibenzo-p-dioxins by recombinant white-rot basidiomycete Coriolus hirsutus”, Appl Microbiol Biotechnol. 2005;69(1):22-8.

Membership of Academic Organization

  • Japanese Society of Allergology
  • Japanese Society for Immunology
  • American Academy of Allergy, Asthma & Immunology
  • AAAAI Interest Section, Mechanisms of Asthma and Allergic Inflammation
  • Canadian Society of Allergy and Clinical Immunology
  • Canadian Society for Immunology
  • International Eosinophil Society
  • Honors

    1999 Delegate of Japan, London International Youth Science Forum
    2001 Scholarship from the Foundation for Advancement of Science and Technology
    2003 Delegate of Japan, Stockholm International Youth Science Seminar
    2004 Delegate of Students, Japan Prize Week
    2007 Grant-in-Aid for Young Scientists (Category B) from the Japan Society for the Promotion of Science
    2007 Travel Grant from the Asia Pacific Association of Allergy, Asthma and Clinical Immunology
    2010 FIT Travel Scholarship from the American Academy of Allergy, Asthma & Immunology
    2010 Postdoctoral Fellowship from the Manitoba Health Research Council (co-supported by Manitoba Institute of Child Health)
    2010 Travel Grant from the Canadian Society of Allergy and Clinical Immunology
    2011 FIT Travel Scholarship from the American Academy of Allergy, Asthma & Immunology
    2011 1st place poster award (Postdoc category) at the Manitoba Neuroscience Network
    2011 Young Investigator Award from the International Eosinophil Society 7th Biennial Symposium
    2011 Travel Allowance from the Manitoba Health Research Council
    2012 Alain de Weck Travel Grant from the Collegium International Allergologicum
    2013 FIT Travel Scholarship from the American Academy of Allergy, Asthma & Immunology