研究業績 (2009)
(2009) 2008 2007 2006 2005 2004 2003 2002 2001
酸素輸液全般に関する論文
| 1 |
Artificial Oxygen Carriers, Hemoglobin Vesicles and Albumin-Hemes, Based on Bioconjugate Chemistry. Tsuchida E, Sou K, Nakagawa A, Sakai H, Komatsu T, Kobayashi K. Bioconjugate Chem. (in press). [DOI: 10.1021/bc800431d] |
| 2 |
人工赤血球の過去、現在、未来. 酒井宏水、土田英俊. ファルマシア 2009, 45, 23. |
ヘモグロビン小胞体関連
| 1 |
Pharmacokinetic analysis of hemoglobin vesicles for red blood cell substitution in a rat model of hemorrhagic shock. K. Taguchi, T. Maruyama, Y. Iwao, H. Sakai, K. Kobayashi, H. Horinouchi, E. Tsuchida, T. Kai, M. Otagiri. J. Controlled Release (in press). |
| 2 |
Effect of hemoglobin vesicles, cellular-type artificial oxygen carriers, on the ex vivo expansion of human hematopoietic stem/progenitor cells using a coculture system with human stromal cells. M. Yamaguchi, M. Fujihara, S. Wakamoto, H. Sakai, E. Tsuchida, H. Azuma, H. Ikeda. ASAIO J. (in press). |
| 3 |
Effect of hemoglobin vesicles, cellular-type artificial oxygen carriers, on the ex vivo expansion of human hematopoietic stem/progenitor cells using a coculture system with human stromal cells. M. Yamaguchi, M. Fujihara, S. Wakamoto, H. Sakai, E. Tsuchida, H. Azuma, H. Ikeda. ASAIO J. (in press). |
| 4 |
Hemoglobin-vesicle, a cellular artificial oxygen carrier, that fulfils the physiological roles of the red blood cells structure. H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida. Adv. Exp. Med. Biol. (in press). |
| 5 |
Characterization and Cytotoxicity of Self-Organized Assemblies of Curcumin and Amphiphatic Poly(Ethylene Glycol). Sou K, Oyajobi BO, Goins B, Phillips WT, Tsuchida E. J. Biomed. Nanotechnol. (in press). |
| 6 |
Hemoglobin-Vesicles and Red Blood Cells as Carriers of Carbon Monoxide Prior to Oxygen for Resuscitation after Hemorrhagic Shock in a Rat Model. Sakai H, Horinouchi H, Kobayashi K, Tsuchida E. Shock (in press). |
| 7 |
Review of Hemoglobin-Vesicles as Artificial Oxygen Carriers. Sakai H, Sou K, Horinouchi H, Kobayashi K, Tsuchida E. Artif. Organs 2009, 33, 139. [DOI: 10.1111/j.1525-1594.2008.00698.x] |
| 8 |
Fluid Resuscitation with Artificial Oxygen Carriers in Hemorrhaged Rats: Profiles of Hb-Vesicles Degradation and Hematopoiesis for 14 days. Sakai H, Seishi Y, Obata Y, Takeoka S, Horinouchi H, Tsuchida E, Kobayashi K. Shock 2009, 31, 192. [DOI: 10.1097/SHK.0b013e31817d4066] |
| 9 |
Histopathological Changes of Rat Brain after Direct Injection of Hemoglobin-Vesicles (Oxygen Carriers) and Neurological Impact in an Intracerebral Hemorrhage Model. Sakai H, Okamoto M, Ikeda E, Horinouchi H, Kobayashi K, Tsuchida E. J. Biomed. Mater. Res. A (in press). [DOI: 10.1002/jbm.a.32164] |
| 10 |
Influence of Hemoglobin Vesicles, Cellular-Type Artificial Oxygen Carriers, on Human Umbilical Cord Blood Hematopoietic Progenitor Cells in vitro. Yamaguchi M, Fujihara M, Wakamoto S, Sakai H, Takeoka S, Tsuchida E, Hamada H, Azuma H, Ikeda H. J. Biomed. Mater. Res. A 2009, 88A, 34. [DOI: 10.1002/jbm.a.31857] |
| 11 |
Systemic Administration of Hemoglobin Vesicles Elevates Tumor Tissue Oxygen Tension and Modifies Tumor Response to Irradiation. Yamamoto M, Izumi Y, Horinouchi H, Teramura Y, Sakai H, Kohno M, Watanabe M, Adachi T, Ikeda E, Takeoka S, Tsuchida E, Kobayashi K. J. Surg. Res. 2009, 151, 48. [DOI: 10.1016/j.jss.2007.12.770] |
(日本語)
| 1 |
ヘモグロビン小胞体を含有する血液検体の臨床検査. 宗 慶太郎、小峰 梨沙、酒井 宏水、小林 紘一、土田 英俊、村田 満. 人工血液 (in press). |
研究業績 (2008)
2009 (2008) 2007 2006 2005 2004 2003 2002 2001
ヘモグロビン小胞体関連
| 1 |
Generation of Functional Erythrocytes from Human Embryonic Stem Cell-Derived Definitive Hematopoiesis. Ma F, Ebihara Y, Umeda K, Sakai H, Hanada S, Zhang H, Zaike Y, Tsuchida E, Nakahata T, Nakauchi H, Tsuji K. Proc. Natl. Acad. Sci. U. S. A. 2008, 105, 13087. [DOI: 10.1073/pnas.0802220105] |
| 2 |
The Role of Luminal Factors in the Recovery of Gastric Function and Behavioral Changes after Chronic Helicobacter Pylori Infection. Verdu EF, Bercik P, Huang XX, Lu J, Al-Mutawaly N, Sakai H, Tompkins TA, Croitoru K, Tsuchida E, Perdue M, Collins SM. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 295, G664 [DOI: 10.1152/ajpgi.90316.2008] |
| 3 |
NO and CO Binding Profiles of Hemoglobin-Vesicles as Artificial Oxygen Carriers. Sakai H, Sato A, Sobolewski P, Takeoka S, Frangos JA, Kobayashi K, Intaglietta M, Tsuchida E. Biochim. Biophys. Acta. 2008, 1784, 1441. [DOI: 10.1016/j.bbapap.2008.03.007] |
| 4 |
Haemoglobin-Vesicles as Artificial Oxygen Carriers: Present Situation and Future Visions. Sakai H, Sou K, Horinouchi H, Kobayashi K, Tsuchida E. J. Intern. Med. 2008, 263, 4. [DOI: 10.1111/j.1365-2796.2007.01893.x] |
| 5 |
Encapsulation of Concentrated Hemoglobin Solution in Phospholipid Vesicles Retards the Reaction with NO, but not CO, by Intracellular Diffusion Barrier. Sakai H, Sato A, Masuda K, Takeoka S, Tsuchida E. J. Biol. Chem. 2008, 283, 1508. [DOI: 10.1074/jbc.M7076602003] |
| 6 |
Electrostatic Interactions and Complement Activation on the Surface of Phospholipid Vesicle Containing Acidic Lipids: Effect of the Structure of Acidic Groups. Sou K, Tsuchida E. Biochim. Biophys. Acta 2008, 1778, 1035. [DOI: 10.1016/j.bbamem.2008.01.006] |
| 7 |
Loading of Curcumin into Macrophages Using Lipid-Based Nanoparticles. Sou K, Inenaga S, Takeoka S, Tsuchida E. Int. J. Pharm. 2008, 352, 287. [DOI: 10.1016/j.ijpharm.2007.10.033] |
(日本語)
| 1 |
FDA Workshop on Hemoglobin Based Oxygen Carriersに参加して. 酒井宏水、堀之内宏久、小林紘一. 人工血液 2008, 16, 23. |
| 2 |
海外文献紹介: ヘモグロビン内包リポソームによる脳への酸素供給：出血性ショックラットモデルでのPETイメージングによる評価. 宗 慶太郎. 人工血液 2008, 16, 169. |
| 3 |
多波長パルス分光法を用いたHb小胞体用パルスオキシメータに関する研究. 須崎裕典、酒井宏水、小林直樹、池田達彦、堀之内宏久、小林 紘一、武田 朴、戸川 達男、土田英俊. . 人工血液 2008, 16, 198. |
アルブミン-ヘム関連
| 1 |
Protein Nanotubes Comprised of an Alternate Layer-by-Layer Assembly using a Polycation as an Electrostatic Glue. Qu X, Lu G, Tsuchida E, Komatsu T. Chem. Eur. J. 2008, 14, 10303. [DOI: 10.1002/chem.200800771] |
| 2 | Human Serum Albumin Nanotubes Comprising Layer-by-Layer Assembly with Polycation. Lu G, Tsuchida E, Komatsu T. Chem. Lett. 2008, 37, 972. [DOI: 10.1246/cl.2008.972] |
| 3 |
Structure, Photophysical Property, and Cytotoxicity of Human Serum Albumin Complexed with Tris(Dicarboxymethylene)[60]Fullerene. Qu X, Komatsu T, Sato T, Glatter O, Horinouchi H, Kobayashi K, Tsuchida E. Bioconjugate Chem. 2008, 19, 1556. [DOI: 10.1021/bc800207j] |
| 4 |
Enhanced Radiation Response of a Solid Tumor with the Artificial Oxygen Carrier ‘Albumin-Heme’. Horinouchi H, Yamamoto H, Komatsu T, Huang Y, Tsuchida E, Kobayashi K. Cancer Sci. 2008, 99, 1274. [DOI: 10.1111/j.1349-7006.2008.00811.x] |
| 5 |
O2 Binding to Human Serum Albumin Incorporating Iron Porphyrin with a Covalently Linked Methyl-L-Histidine Isomer. Nakagawa A, Iizuka M, Komatsu T, Tsuchida E. Bioconjugate Chem. 2008, 19, 581. [DOI: 10.1021/bc700400n] |
(日本語図書)
| 1 |
交互積層法による蛋白質ナノチューブの合成, 小松晃之, 有機・無機・金属ナノチューブー非カーボンナノチューブ系の最新技術と応用 (清水敏美, 木島剛 編) 2008, 82. フロンティア出版 |
研究業績 (2007)
2009 2008 (2007) 2006 2005 2004 2003 2002 2001
ヘモグロビン小胞体関連
| 1 |
Rheological Properties of Hemoglobin Vesicles (Artificial Oxygen Carriers) Suspended in a Series of Plasma-Substitute Solutions. Sakai H, Sato A, Takeoka S, Tsuchida E. Langmuir 2007, 23, 8121. [DOI: 10.1021/la7004503] |
| 2 |
Effects of Hemoglobin Vesicles, a Liposomal Artificial Oxygen Carrier, on Hematological Responses, Complement and Anaphylactic Reactions in Rats. Abe H, Azuma H, Yamaguchi M, Fujihara M, Ikeda H, Sakai H, Takeoka S, Tsuchida E. Artif. Cells Blood Substit. Biotechnol. 2007, 35, 157. [DOI: 10.1080/10731190601188224] |
| 3 |
Selective Uptake of Surface-Modified Phospholipid Vesicles by Bone Marrow Macrophages in vivo. Sou K, Goins B, Takeoka S, Tsuchida E, Phillips WT. Biomaterials 2007, 28, 2655. [DOI: 10.1016/j.biomaterials.2007.01.041] |
| 4 |
One-Year Observation of Wistar Rats after Intravenous Infusion of Hemoglobin-Vesicles (Artificial Oxygen Carriers). Sakai H, Tsuchida E, Horinouchi H, Kobayashi K. Artif. Cells Blood Substit. Biotechnol. 2007, 35, 81. [DOI: 10.1080/10731190600974582] |
| 5 |
Hemoglobin Vesicles Reduce Hypoxia-Related Inflammation in Critically Ischemic Hamster Flap Tissue. Plock JA, Tromp AE, Contaldo C, Spanholtz T, Sinovcic D, Sakai H, Tsuchida E, Leunig M, Banic A, Erni D. Crit. Care. Med., 2007, 35, 899. [DOI: 10.1097/01.CCM.0000257463.71761.97] |
| 6 |
Poly(Ethylene Glycol)-Conjugated Phospholipids in Aqueous Micellar Solutions: Hydration, Static Structure, and Interparticle Interactions. Sato T, Sakai H, Sou K, Buchner R, Tsuchida E. J. Phys. Chem. B 2007, 111, 1393. [DOI: 10.1021/jp067011k] |
| 7 |
Hemoglobin-Vesicles for a Transfusion Alternative and Targeted Oxygen Delivery. Sakai H, Tsuchida E. J. Liposome Res. 2007, 17, 227. [DOI: 10.1080/08982100701529904] |
| 8 |
Solution to the Problems of Acellular Hbs by Encapsulation, and the Intrinsic Issues of Hb-Vesicles as a Molecular Assembly. Sakai H, Sou K, Tsuchida E. Trans. Altern. Trans. Med. 2007, 9, 226. [DOI: 10.1111/j.1778-428X.2007.00089.x] |
| 9 |
Hemoglobin Vesicles to Treat Hypoxia in Critically Ischemic Tissue. Erni D, Wettstein R, Contaldo C, Plock J, Rafatmehr N, Sakai H, Tsuchida E. Artif. Blood 2007, 15, 58. |
(日本語)
| 1 |
各種代用血漿剤に分散させたヘモグロビン小胞体(人工赤血球)とその血液混合系のレオロジー特性. 佐藤敦、酒井宏水、武岡真司、土田英俊. 日本ヘモレオロジー学会誌 2007, 53, 3. |
| 2 |
ヘモグロビン小胞体(HbV)-リコンビナントアルブミン分散溶液による40%交換輸血:ラット脾臓内HbV代謝と造血に関する2週間の観察. 酒井宏水、堀之内宏久、山本学、池田 栄二、武岡真司、高折益彦、土田英俊、小林紘一. 日本輸血細胞治療学会誌 2007, 53, 47. |
| 3 |
輸血の代替が可能な酸素輸液の実現と組織再生技術. 酒井宏水、土田英俊. 環境と健康 2007, 20, 464. |
アルブミン-ヘム関連
| 1 |
Nakagawa A, Komatsu T, Huang Y, Lu G, Tsuchida E. O2-Binding Albumin Thin Films: Solid Membranes of Poly(Ethylene Glycol)-Conjugated Human Serum Albumin Incorporating Iron Porphyrin. Bioconjugate Chem. 2007, 18, 1673. [DOI: 10.1021/bc070086m] |
| 2 |
Komatsu T, Nakagawa A, Zunszain PA, Curry S, Tsuchida E. Genetic Engineering of the Heme Pocket in Human Serum Albumin: Modulation of O2 Binding of Iron Protoporphyrin IX by Variation of Distal Amino Acids. J. Am. Chem. Soc. 2007, 129, 11286. [DOI: 10.1021/ja074179q] |
| 3 |
Artificial Hemoprotein Nanotubes. Lu G, Komatsu T, Tsuchida E. Chem. Commun. 2007, 28, 2980. [DOI: 10.1039/b704135g] |
| 4 |
meso-Tetrakis(α,α,α,α-o-amidophenyl)porphinatoiron(II) Bearing a Proximal Histidyl Group at the β-Pyrrolic Position via an Acyl Bond: Synthesis and O2 Coordination in Aqueous Media. Nakagawa A, Komatsu T, Tsuchida E. Chem. Lett. 2007, 36, 640. [DOI: 10.1246/cl.2007.640] |
| 5 |
Influence of O2-Carrying Plasma Hemoprotein "Albumin-Heme" on Complement System and Platelet Activation in vitro and Physiological Responses to Exchange Transfusion. Komatsu T, Huang YB, Wakamoto S, Abe H, Fujihara M, Azuma H, Ikeda H, Yamamoto H, Horinouchi H, Kobayash K, E. Tsuchida. J. Biomed. Mater. Res. A 2007, 81A, 821. [DOI: 10.1002/jbm.a.31016] |
| 6 |
Induced Long-Range Attractive Potentials of Human Serum Albumin by Ligand Binding. Sato T, Komatsu T, Nakagawa A, Tsuchida E. Phys. Rev. Lett. 2007, 98, 208101-1-4. [DOI: 10.1103/PhysRevLett.98.208101] |
研究業績 (2006)
2009 2008 2007 (2006) 2005 2004 2003 2002 2001
ヘモグロビン小胞体関連
| 1 |
Hemoglobin-Vesicles as a Transfusion Alternative. Tsuchida E, Sakai H, Horinouchi H, Kobayashi K. Artif. Cells Blood Substit. Biotechnol. 2006, 34, 581. [DOI: 10.1080/10731190600973907] |
| 2 |
Hemoglobin Vesicles Containing Methemoglobin and L-Tyrosine to Suppress Methemoglobin Formation in vitro and in vivo. Atoji T, Aihara M, Sakai H, Tsuchida E, Takeoka S. Bioconjugate Chem. 2006, 17, 1241. [DOI: 10.1021/bc050349h] |
| 3 |
Performances of PEG-Modified Hemoglobin-Vesicles as Artificial Oxygen Carriers in Microcirculation. Sakai H, Tsuchida E. Clin. Hemorheol. Microcirc. 2006, 34, 335. |
| 4 |
Acute 40 percent exchange-transfusion with hemoglobin-vesicles (HbV) suspended in recombinant human serum albumin solution: degradation of HbV and erythropoiesis in a rat spleen for 2 weeks. Sakai H, Horinouchi H, Yamamoto M, Ikeda E, Takeoka S, Takaori M, Tsuchida E, Kobayashi K. Transfusion 2006, 46, 339. [DOI: 10.1111/j.1537-2995.2006.00727.x] |
| 5 |
Fluid Resuscitation with Hemoglobin-Vesicle Solution Does not Increase Hypoxia or Inflammatory Responses in Moderate Hemorrhagic Shock. Goto Y, Terajima K, Tsueshita T, Miyashita M, Horinouchi H, Sakai H, Tsuchida E, Sakamoto A. Biomed. Res. 2006, 27, 283. [DOI: 10.2220/biomedres.27.283] |
(Book)
| 1 | Blood Substitutes; Sakai H, Tsuchida E. In: Wiley Encyclopedia of Biomedical Engineering. Akay M. (Ed.) 2006, 613-621, John Wiley & Sons, Inc., Hoboken, NJ. |
| 2 | Blood Substitutes Efficacy: Microvascular and Theological Determinants. Tsai AG, Cabrales P, Sakai H, Intaglietta M. In: Microvascular Research: Biology and Pathology, Vol. 2. (Ed: Shepro D);2006, 1095-1103, San Diego: Elsevier. |
| 3 | Hemoglobin-Vesicles as a Molecular Assembly: Characteristics of Preparation Process and Performances as Artificial Oxygen Carriers. Sakai H, Sou K, Takeoka S, Kobayashi K,Tsuchida E. In Blood Substitutes Chapt. 44, (Ed. By Winslow RM); 2006, 514-522, Elsevier. |
(日本語)
| 1 |
ハムスター皮下の細動脈血流を一過性に遮断するモデルを用いたP50値が異なるHb小胞体の酸素放出挙動. 酒井宏水、ペドロカブラレス、エミ G. ツァイ、土田英俊、マルコス インタリエッタ. 人工血液 2006, 14, 130-137 (二次掲載) |
アルブミン-ヘム関連
| 1 |
Photosensitized Reduction of Water to Hydrogen Using Human Serum Albumin Complexed with Zinc-Protoporphyrin IX. Komatsu T, Wang RM, Zunszain PA, Curry S, Tsuchida E. J. Am. Chem. Soc. 2006 128, 16297. [DOI: 10.1021/ja0656806] |
| 2 |
PEGylated Albumin-Heme as an Oxygen-Carrying Plasma Expander: Exchange Transfusion into Acute Anemia Rat Model. Huang Y, Komatsu T, Yamamoto H, Horinouchi H, Kobayashi K, Tsuchida E. Biomaterials 2006 27, 4477. [DOI: 10.1016/j.biomaterials.2006.04.008] |
| 3 |
Huang YB, Komatsu T, Wang RM, Nakagawa A, Tsuchida E. Poly(Ethylene Glycol)-Conjugated Human Serum Albumin Including Iron Porphyrins: Surface Modification Improves the O2-Transporting Ability. Bioconjugate Chem. 2006 17, 393. [DOI: 10.1021/bc050315+] |
| 4 |
Human serum albumin hybrid incorporating tailed porphyrinatoiron(II) in the α,α,α,β-conformer as an O2-binding site. Nakagawa A, Komatsu T, Iizuka M, Tsuchida E. Bioconjugate Chem. 2006 17, 146. [DOI: 10.1021/bc050154+] |
(図書)
| 1 | Albumin-Heme: A Synthetic Heme-Based Oxygen Carrier. T. Komatsu, Y. Huang, H. Yamamoto, H. Horinouchi H, Kobayashi K, Tsuchida E. In Blood Substitutes Chapt. 44, (Ed. By Winslow RM), 2006, 532-539, Elsevier. |
(日本語)
| 1 |
ポリ（エチレングリコール）修飾アルブミン-ヘム：酸素輸送血漿増量剤としての溶液物性と機能. 小松晃之, 黄宇彬, 王栄民, 中川晶人, 山本尚志, 堀之内宏久, 小林紘一, 土田英俊. 人工血液 2006, 14, 47. |
研究業績 (2005)
2009 2008 2007 2006 (2005) 2004 2003 2002 2001
酸素輸液全般に関する論文、図書
| 1 |
Oxygen Infusions (Hemoglobin-Vesicles and Albumin-Hemes) Based on Nano-Molecular Sciences. Tsuchida E, Sakai H, Komatsu T, Takeoka S, Huang Y, Sou K, Nakagawa A, Teramura Y, Kobayashi K. Polym. Adv. Tec. 2005, 16, 73. [DOI: 10.1002/pat.559] |
| 2 |
Safety and Efficacy of Hemoglobin-Vesicles and Albumin-Hemes. Kobayashi K, Horinouchi H, Watanabe M, Izumi Y, Teramura Y, Nakagawa A, Huang Y, Sou K, Sakai H, Komatsu T, Takeoka S, Tsuchida E. In: Artificial Oxygen Carrier: Its Front Line, Keio University International Symposia for Life Sciences and Medicine Vol.12, Eds. by K. Kobayashi, E. Tsuchida, H. Horinouchi; 2005, 1-21 Springer-Verlag. |
| 3 | 土田英俊、酒井宏水、小松晃之、小林紘一. 「酸素輸液(人工赤血球)の臨床応用」先端医療シリーズ３７「人工臓器・再生医療の最先端」第16章-4, 2005, 279-286, 寺田国際事務所 / 先端医療技術研究所 |
ヘモグロビン小胞体関連
| 1 |
Is Hemoglobin in Hemoglobin Vesicles Infused for Isovolemic Hemodilution Necessary to Improve Oxygenation in Critically Ischemic Hamster Skin? Plock JA, Contaldo C, Sakai H, Tsuchida E, Leunig M, Banic A, Menger MD, Erni D. Am. J. Physiol. Heart Circ. Physiol. 2005, 289, H2624. [DOI: 10.1152/ajpheart.00308.2005] |
| 2 |
Oxygen Release from Low and Normal P50 Hb Vesicles in Transiently Occluded Arterioles of the Hamster Window Model. Sakai H, Cabrales P, Tsai AG, Tsuchida E, Intaglietta M. Am. J. Physiol. Heart Circ. Physiol. 2005, 288, H2897. [DOI: 10.1152/ajpheart.01184.2004] |
| 3 |
New Generation of Hemoglobin-Based Oxygen Carriers Evaluated for Oxygenation of Critically Ischemic Hamster Flap Tissue. Contaldo C, Plock J, Sakai H, Takeoka S, Tsuchida E, Leunig M, Banic A, Erni D. Crit. Care Med., 2005, 33, 806. [DOI: 110.1097/01.CCM.0000159195.12111.CE] |
| 4 |
Oxygen Transport by Low and Normal Oxygen Affinity Hemoglobin Vesicles in Extreme Hemodilution. Cabrales P, Sakai H, Tsai AG, Takeoka S, Tsuchida E, Intaglietta M. Am. J. Physiol. Heart Circ. Physiol. 2005, 288, H1885. [DOI: 10.1152/ajpheart.01004.2004] |
| 5 |
Circulation Kinetics and Organ Distribution of Hb-Vesicles Developed as a Red Blood Cell Substitute. Sou K, Klipper R, Goins B, Tsuchida E, Phillips WT. J. Pharm. Exp. Ther. 2005, 312, 702. [DOI: 10.1124/jpet.104.074534] |
(図書)
| 1 | Hemoglobin-vesicles (HbV) as Artificial Oxygen Carriers. Sakai H, Sou K, Takeoka S, Kobayashi K, Tsuchida E. In: Artificial Oxygen Carrier: Its Front Line, Keio University International Symposia for Life Sciences and Medicine Vol.12. Eds. by Kobayashi K, Tsuchida E, Horinouchi H; 2005, 135-168, Springer-Verlag. |
(日本語)
| 1 |
酒井宏水, 土田英俊. 目でみるバイオ「微小血管内を均一に流れる人工赤血球とその運命」. バイオサイエンス と インダストリー;2005, 63, 571. |
| 2 | 「医療用マテリアルと機能膜」人工赤血球 第5章, 酒井宏水、宗慶太郎、武岡真司、小林紘一、土田英俊. 2005, 107-118, シーエムシー出版 |
| 3 |
土田英俊、小林紘一. 輸血製剤への新しい取り組み：人工赤血球、「周術期の輸液・輸血療法」麻酔科プラクティス18 (稲田英一 編) , 2005, 270-273, 文光堂 |
| 4 |
人工酸素運搬体の開発 –現状と将来展望-. 堀之内宏久, 泉陽太郎, 小林紘一, 土田英俊. 検査と技術 2005, 33, 879. |
| 5 |
人工赤血球(人工酸素運搬体)の臨床応用. 小林紘一, 山崎真敬, 饗庭了, 四津良平, 土田英俊. ハートナーシング 2005, 18, 965. |
アルブミン-ヘム関連
| 1 |
O2 and CO Binding Properties of Artificial Hemoproteins Formed by Complexing Iron Protoporphyrin Ix with Human Serum Albumin Mutants. Komatsu T, Ohmichi N, Nakagawa A, Zunszain PA, Curry S, Tsuchida E. J. Am. Chem. Soc., 2005, 127, 15933. [DOI: 10.1021/ja054819u] |
| 2 |
Albumin clusters: Structurally defined protein tetramer and oxygen carrier including thirty-two iron(II) porphyrins. Komatsu T, Oguro Y, Nakagawa A, Tsuchida E. Biomacromolecules, 2005, 6, 3397. [DOI: 10.1021/bm050454u] |
| 3 |
Heat-resistant oxygen-carrying hemoproteins consist of recombinant xylanases and synthetic iron(II) porphyrin. Komatsu T, Ishihara S, Tsuchida E, Nishide H, Morokuma C, Nakamura S. Biomacromolecules, 2005, 6, 1489. [DOI: 10.1021/bm049255l] |
| 4 |
Human Serum Albumin Bearing Covalently Attached Iron(Ii) Porphyrins as O2-Coordination Sites. Wang RM, Komatsu T, Nakagawa A, Tsuchida E. Bioconjugate Chem. 2005, 16, 23. [DOI: 10.1021/bc049859m] |
(図書)
| 1 | Komatsu T, Tsuchida E. Oxygen-Carrying Plasma Hemoprotein Including Synthetic Heme. In: Artificial Oxygen Carrier: Its Front Line, Keio University International Symposia for Life Sciences and Medicine Vol.12. Eds. by Kobayashi K, Tsuchida E, Horinouchi H; 2005, 193-204, Springer-Verlag. |
研究業績 (2004)
2009 2008 2007 2006 2005 (2004) 2003 2002 2001
酸素輸液全般に関する図書
| 1 | 人工赤血球, 土田英俊, 武岡真司, 小松晃之, 酒井宏水, 新訂版・表面科学の基礎と応用 2004; 第5章第12節:1333-1336,日本表面科学会, エヌ・ティー・エス社 |
| 2 | 土田英俊、酸素輸液の安全性と人工赤血球としての効果. TMDC Mate. 2004, 233, 4. |
ヘモグロビン小胞体関連
| 1 |
Physiological Capacity of the Reticuloendothelial System for the Degradation of Hemoglobin Vesicles (Artificial Oxygen Carriers) after Massive Intravenous Doses by Daily Repeated Infusions for 14 Days. Sakai H, Masada Y, Horinouchi H, Ikeda E, Sou K, Takeoka S, Suematsu M, Takaori M, Kobayashi K, Tsuchida E. J. Pharm. Exp. Ther. 2004, 311, 874. [DOI: 10.1124/jpet.104.073049] |
| 2 |
Hemorrhagic Shock Resuscitation with an Artificial Oxygen Carrier, Hemoglobin Vesicle, Maintains Intestinal Perfusion and Suppresses the Increase in Plasma Tumor Necrosis Factor-α. Yoshizu A, Izumi Y, Park S, Sakai H, Takeoka S, Horinouchi H, Ikeda E, Tsuchida E, Kobayashi K. ASAIO J. 2004, 50, 458. [DOI: 10.1097/01.MAT.0000136508.51676.EF] |
| 3 |
Reduction of methemoglobin via electron transfer from photoreduced flavin: Restoration of O2-binding of concentrated hemoglobin solution coencapsulated in phospholipid vesicles. Sakai H, Masada Y, Onuma H, Takeoka S, Tsuchida E. Bioconjugate Chem. 2004, 15, 1037. [DOI: 10.1021/bc049913z] |
| 4 |
Metabolism of Hemoglobin-Vesicles (Artificial Oxygen Carriers) and Their Influence on Organ Functions in a Rat Model. Sakai H, Horinouchi H, Masada Y, Takeoka S, Ikeda E, Takaori M, Kobayashi K, Tsuchida E. Biomaterials 2004, 25, 4317. [DOI: 10.1016/j.biomaterials.2003.11.005] |
| 5 |
Hemoglobin-Vesicles Suspended in Recombinant Human Serum Albumin for Resuscitation from Hemorrhagic Shock in Anesthetized Rats. Sakai H, Masada Y, Horinouchi H, Yamamoto M, Ikeda E, Takeoka S, Kobayashi K, Tsuchida E. Crit. Care Med. 2004, 32, 539. [DOI: 10.1097/01.CCM.0000109774.99665.22] |
| 6 |
Detection of lipopolysaccharide in hemoglobin-vesicles by Limulus amebocyte lysate test with kinetic-turbidimetric gel clotting analysis and pretreatment of surfactant. Sakai H, Hisamoto S, Fukutomi I, Sou K, Takeoka S, Tsuchida E. J. Pharm. Sci. 2004, 93, 310. [DOI: 10.1002/jps.10525] |
| 7 |
An Effective Blood Substitutes That Targets Oxygen Delivery, Increases Plasma Viscosity, and Has High Oxygen Affinity. Tsai AG, Sakai H, Wettstein R, Kerger H, Intaglietta M. Trans. Altern. Trans. Med. 2004, 5, 507. [DOI: 10.1111/j.1778-428X.2004.tb00089.x] |
アルブミン-ヘム関連
| 1 |
Safety Evaluation of an Artificial O2 Carrier as a Red Blood Cell Substitute by Blood Biochemical Tests and Histopathology Observations. Huang YB, Komatsu T, Yamamoto H, Horinouchi H, Kobayashi K, Tsuchida E. ASAIO J. 2004, 50, 525. |
| 2 |
Exchange Transfusion with Synthetic Oxygen-Carrying Plasma Protein "Albumin-Heme" Into an Acute Anemia Rat Model after Seventy-Percent Hemodilution. Komatsu T, Yamamoto H, Huang YB, Horinouchi H, Kobayashi K, Tsuchida E. J. Biomed. Mater. Res. A 2004, 71A, 644. [DOI: 10.1002/jbm.a.30200] |
| 3 |
Physicochemical Characterization of Cross-Linked Human Serum Albumin Dimer and its Synthetic Heme Hybrid as an Oxygen Carrier. Komatsu T, Oguro Y, Teramura Y, Takeoka S, Okai J, Anraku M, Otagiri M, Tsuchida E. Biochim. Biophys. Acta 2004, 1675, 21. [DOI: 10.1016/j.bbagen.2004.08.010] |
| 4 |
Dioxygenation of Human Serum Albumin Having a Prosthetic Heme Group in a Tailor-Made Heme Pocket. Komatsu T, Ohmichi N, Zunszain PA, Curry S, Tsuchida E. J. Am. Chem. Soc. 2004, 126, 14304. [DOI: 10.1021/ja046022t] |
| 5 |
Synthesis of protoheme IX Derivatives with a Covalently Linked Proximal Base and their Human Serum Albumin Hybrids as Artificial Hemoprotein. Nakagawa A, Ohmichi N, Komatsu T, Tsuchida E. Org. Biomol. Chem. 2004, 2, 3108. [DOI: 10.1039/b409017a] |
| 6 |
Exchange Transfusion with Entirely Synthetic Red-Cell Substitute Albumin-Heme into Rats: Physiological Responses and Blood Biochemical Tests. Huang YB, Komatsu T, Yamamoto H, Horinouchi H, Kobayashi K, Tsuchida E. J. Biomed. Mater. Res. A 2004, 71A, 63. [DOI: 10.1002/jbm.a.30127] |
(日本語)
| 1 |
酸素輸送合成ヘム蛋白質”アルブミン−ヘム”の創製と酸素輸液の展開. 小松晃之, 土田英俊. 体液・代謝管理 2004, 20, 3. |
研究業績 (2003)
2009 2008 2007 2006 2005 2004 (2003) 2002 2001
酸素輸液全般に関する論文
| 1 |
酸素輸液(人工赤血球)の安全度と体組織への酸素供給 土田英俊, 宗慶太郎, 酒井宏水, 小松晃之, 武岡真司, 堀之内宏久, 末松誠, 小林紘一. 麻酔 2003, 53, S55. |
| 2 |
臨床応用可能な酸素輸液(人工赤血球)の創製に関する研究. 土田英俊. 人工臓器 2003, 32, 29. |
ヘモグロビン小胞体関連
| 1 |
Prolonged Oxygen-Carrying Ability of Hemoglobin Vesicles by Coencapsulation of Catalase in vivo. Teramura Y, Kanazawa H, Sakai H, Takeoka S, Tsuchida E. Bioconjugate Chem. 2003, 14, 1171. [DOI: 10.1021/bc0340619] |
| 2 |
O2 Release from Hb Vesicles Evaluated Using an Artificial, Narrow O2-Permeable Tube: Comparison with RBCs and Acellular Hbs. Sakai H, Suzuki Y, Kinoshita M, Takeoka S, Maeda N, Tsuchida E. Am. J. Physiol. Heart Circ. Physiol. 2003, 285, H2543. [DOI: 10.1152/ajpheart.00537.2003] |
| 3 |
Effective Encapsulation of Proteins into Size-Controlled Phospholipid Vesicles Using Freeze-Thawing and Extrusion. Sou K, Naito Y, Endo T, Takeoka S, Tsuchida E. Biotech. Prog. 2003, 19, 1547. [DOI: 10.1021/bp0201004] |
| 3 |
Improved Oxygenation in Ischemic Hamster Flap Tissue is Correlated with Increasing Hemodilution with Hb Vesicles and their O2 Affinity. Contaldo C, Schramm S, Wettstein R, Sakai H, Takeoka S, Tsuchida E, Leunig M, Banic A, Erni D. Am. J. Physiol. Heart Circ. Physiol. 2003, 285, H1140. [DOI: 10.1152/ajpheart.00285.2003] |
| 4 |
Normovolemic Hemodilution with Hb Vesicle Solution Attenuates Hypoxia in Ischemic Hamster Flap Tissue. Erni D, Wettstein R, Schramm S, Contaldo C, Sakai H, Takeoka S, Tsuchida E, Leunig M, Banic A. Am. J. Physiol. Heart Circ. Physiol. 2003, 284, H1702. [DOI: 10.1152/ajpheart.00821.2002] |
| 5 |
Pretreatment of Serum Containing Hemoglobin Vesicles (Oxygen Carriers) to Prevent their Interference in Laboratory Tests. Sakai H, Tomiyama K, Masada Y, Takeoka S, Horinouchi H, Kobayashi K, Tsuchida E. Clin. Chem. Lab. Med. 2003, 41, 222. |
| 6 |
Oxygen Affinity of Hemoglobin Regulates O2 Consumption, Metabolism, and Physical Activity. Shirasawa T, Izumizaki M, Suzuki Y, Ishihara A, Shimizu T, Tamaki M, Huang F, Koizumi K, Iwase M, Sakai H, Tsuchida E. J. Biol. Chem. 2003, 278, 5035-5043. [DOI: 10.1074/jbc.M211110200] |
(日本語)
| 1 |
酸素輸液(人工赤血球). 土田英俊, 酒井宏水, 武岡真司, 宗慶太郎, 小林紘一. 医学のあゆみ 2003, 205, 558. |
| 2 |
呼吸不全の遺伝子治療-変異ヘモグロビンの研究を通じて-. 黄 菲, 玉置正勝, 清水孝彦, 泉崎雅彦, 本間生夫, 石原昭彦, 酒井宏水, 土田英俊, 井上洋西, 上嶋健治, 白澤卓二. 呼吸 2003, 22, 101. |
| 3 |
酸素輸液ヘモグロビン小胞体に混在するリポポリサッカライドの定量法. 久本秀治, 酒井宏水, 福富一平, 宗 慶太郎, 武岡真司, 土田英俊. 人工血液 2003, 11, 173. |
アルブミン-ヘム関連
| 1 |
Oxygen-Carrying Plasma Hemoprotein "Albumin-Heme": Nitric Oxide Binding and Physiological Responses after Administration in vivo. Tsuchida E, Komatsu T. Macromol. Symp. 2003, 204, 13. [DOI: 10.1002/masy.200351402] |
| 2 |
Microcalorimetry Investigation of Synthetic Hemoprotein (Albumin-Heme). Huang YB, Komatsu T, Tsuchida E. Polym. Adv. Tech. 2003, 14, 729. [DOI: 10.1002/pat.418] |
| 3 |
Molecular Energy and Electron Transfer Assemblies Made of Self-Organized Lipid-Porphyrin Bilayer Vesicles. Komatsu T, Moritake M, Tsuchida E. Chem. Eur. J. 2003, 9, 4626. [DOI: 10.1002/chem.200305013] |
| 4 |
Compatibility in vitro of Albumin-Heme (O2 Carrier) with Blood Cell Components. Huang YB, Komatsu T, Nakagawa A, Tsuchida E, Kobayashi S. J. Biomed. Mater. Res. A 2003, 66A, 292. [DOI: 10.1002/jbm.a.10573] |
| 5 |
Coordination structure of active site in synthetic hemoprotein (albumin-heme) with dioxygen and carbon monoxide. Tsuchida E, Nakagawa A, Komatsu T. Macromol. Symp. 2003, 195, 275. [DOI: 10.1002/masy.200390134] |
| 6 |
Synthetic dioxygen-carrying hemoprotein. Human serum albumin including iron(II) complex of protoporphyrin IX with an axially coordinated histidylglycyl-propionate. Nakagawa A, Komatsu T, Ohmichi N, Tsuchida E. Chem. Lett. 2003, 32, 504. [DOI: 10.1246/cl.2003.504] |
| 7 |
Human Serum Albumin Incorporating Synthetic Heme: Red Blood Cell Substitute without Hypertension by Nitric Oxide Scavenging. Tsuchida E, Komatsu T, Matsukawa Y, Nakagawa A, Sakai H, Kobayashi K, Suematsu M. J. Biomed. Mater. Res. A 2003, 64A, 257. [DOI: 10.1002/jbm.a.10324] |
| 8 |
Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes. Kobayashi K, Komatsu T, Iwamaru A, Matsukawa Y, Horinouchi H, Watanabe M, Tsuchida E. J. Biomed. Mater. Res. A 2003, 64A, 48. [DOI: 10.1002/jbm.a.10323] |
(日本語)
| 1 |
テトラ（シクロヘキサノイル）基を有するヘムを包接させたアルブミン−ヘム複合体の酸素結合反応 小松晃之, 石原星児, 土田英俊 人工血液 2003, 11, 167. |
研究業績 (2002)
2009 2008 2007 2006 2005 2004 2003 (2002) 2001
ヘモグロビン小胞体関連
| 1 |
Systemic and Microvascular Responses to Hemorrhagic Shock and Resuscitation with Hb Vesicles. Sakai H, Takeoka S, Wettstein R, Tsai AG, Intaglietta M, Tsuchida E. Am. J. Physiol. Heart Circ. Physiol. 2002, 283, H1191. [DOI: 10.1152/ajpheart.00080.2002] |
| 2 |
Model Mice for Presbyterian Hemoglobinopathy (Asn(β 108)-> Lys) Confer Hemolytic Anemia with Altered Oxygen Affinity and Instability of Hb. Suzuki Y, Shimizu T, Sakai H, Tamaki M, Koizumi K, Kuriyama T, Tsuchida E, Koseki H, Shirasawa T. Biochem. Biophys. Res. Commun. 2002, 295, 869. [DOI: 10.1016/S0006-291X(02)00752-0] |
| 3 |
Capillary Blood Flow during Severe Hemodilution Observed by a Noninvasive Transcutaneous Technique Using Flash Epi-Illumination. Sakai H, Sato T, Maekawa Y, Tsuchida E. Microvas. Res. 2002, 64, 120. [DOI: 10.1006/mvre.2002.2415] |
| 4 |
Virus Inactivation in Hemoglobin Solution by Heat Treatment. Abe H, Ikebuchi K, Hirayama J, Fujihara M, Takeoka S, Sakai H, Tsuchida E, Ikeda H. Artif. Cells Blood Substit. Immob. Biotechnol. 2002, 30, 79. |
| 5 |
Characteristics of Bovine Hemoglobin as a Potential Source of Hemoglobin-Vesicles for an Artificial Oxygen Carrier. Sakai H, Masada Y, Takeoka S, Tsuchida E. J. Biochem. 2002, 131, 611. |
| 6 |
Complete Deoxygenation from a Hemoglobin Solution by an Electrochemical Method and Heat Treatment for Virus Inactivation. Huang YB, Takeoka S, Sakai H, Abe H, Hirayama J, Ikebuchi K, Ikeda H, Tsuchida E. Biotechnol. Prog. 2002, 18, 101. [DOI: 10.1021/bp0101233] |
| 7 |
Virus Removal from Hemoglobin Solution Using Planova Membrane. Naito Y, Fukutomi I, Masada Y, Sakai H, Takeoka S, Tsuchida E, Abe H, Hirayama J, Ikebuchi K, Ikeda H. J. Artifi. Org. 2002, 5, 141. |
| 8 |
Carbonylation of Oxyhemoglobin Solution (HbO2 HbCO) Using a Membrane Oxygenator. Fukutomi I, Sakai H, Takeoka S, Tsuchida E, Sakai K. J. Artif. Org. 2002, 5, 102. |
(日本語)
| 1 |
酸素輸液(ヘモグロビン小胞体). 土田英俊, 酒井宏水. 微粒子工学体系 2002, 12, 665. |
| 2 |
酸素輸液(ヘモグロビン小胞体)を含有する血液の生化学検査. 酒井宏水，富山賢一，政田陽平，武岡真司，堀之内宏久，小林紘一，土田英俊. 人工血液 2002, 10, 47. |
アルブミン-ヘム関連
| 1 |
Self-Organized Lipid-Porphyrin Bilayer Membranes in Vesicular Form: Nanostructure, Photophysical Properties, and Dioxygen Coordination. Komatsu T, Moritake W, Nakagawa A, Tsuchida E. Chem. Eur. J. 2002, 8, 5469. [DOI: 10.1002/1521-3765(20021202)8:23<5469::AID-CHEM5469>3.0.CO;2-1] |
| 2 |
Human Serum Albumin Incorporating Synthetic Hemes as an O2-Carrying Hemoprotein: Control of O2-Binding Ability by Heme Structure. Tsuchida E, Komatsu T, Matsukawa Y, Okada T. Macromol. Symp. 2002, 186, 1. [DOI: 10.1002/1521-3900(200208)186:1<1::AID-MASY1>3.0.CO;2-M] |
| 3 |
Effect of heme structure on O2-binding properties of human serum albumin-heme hybrids: Intramolecular histidine coordination provides a stable O2-adduct complex. Komatsu T, Matsukawa Y, Tsuchida E. Bioconjugate Chem. 2002, 13, 397-402. [DOI: 10.1021/bc010067r] |
(日本語)
| 1 |
自己組織化リピドヘム小胞体のナノ構造と酸素結合能. 小松晃之, 森武美保, 土田英俊. 人工血液 2002, 10, 120. |
研究業績 (2001)
2009 2008 2007 2006 2005 2004 2003 2002 (2001)
酸素輸液全般に関する論文
| 1 |
酸素輸液(人工赤血球)の設計原理とその具体的構造. 土田英俊, 小松晃之, 酒井宏水. 血液・免疫・腫瘍 2001, 6, 12-18 |
ヘモグロビン小胞体関連
| 1 |
Effects of Poly(Ethyleneglycol)-Modified Hemoglobin Vesicles on N-Formyl-Methionyl-Leucylphenylalanine-Induced Responses of Polymorphonuclear Neutrophils in vitro. Ito T, Fujihara M, Abe H, Yamaguchi M, Wakamoto S, Takeoka S, Sakai H, Tsuchida E, Ikeda H, Ikebuchi K. Artif. Cells Blood Substit. Immobil. Biotechnol. 2001, 29, 427. [DOI: 10.1081/BIO-100108548] |
| 2 |
Virus Inactivation in Hemoglobin Solution by Heat Treatment. Abe H, Ikebuchi K, Hirayama J, Fujihara M, Takeoka S, Sakai H, Tsuchida E, Ikeda H. Artif. Cells Blood Substit. Immobil. Biotechnol. 2001, 29, 381. [DOI: 10.1081/BIO-100106921] |
| 3 |
Hemoglobin-Vesicles as Oxygen Carriers - Influence on Phagocytic Activity and Histopathological Changes in Reticuloendothelial System. Sakai H, Horinouchi H, Tomiyama K, Ikeda E, Takeoka S, Kobayashi K, Tsuchida E. Am. J. Pathol. 2001, 159, 1079. |
| 4 |
Effects of Poly(Ethyleneglycol)-Modified Hemoglobin Vesicles on Agonist-Induced Platelet Aggregation and Rantes Release in vitro. Wakamoto S, Fujihara M, Abe H, Sakai H, Takeoka S, Tsuchida E, Ikeda H, Ikebuchi K. Artif. Cells Blood Substit. Immobil. Biotechnol. 2001, 29, 191. [DOI: 10.1081/BIO-100103043] |
アルブミン-ヘム関連
| 1 |
Photoreduction of a Self-Assembled (Lipidporphyrinato)Iron(Iii) Complex in Saline by LMCT Excitation: Co-Aggregated Hyaluronic Acid Allows an Irreversible Electron Transfer. Yanagimoto T, Nakagawa A, Komatsu T, Tsuchida E. Bull. Chem. Soc. Jpn. 2001, 74, 2123. [DOI: 10.1246/bcsj.74.2123] |
| 2 |
Iron(II) Complex of Octopus-Porphyrin with a Covalently Linked Proximal Imidazole; Self-Assembly and O2-Coordination in Aqueous Media. Komatsu T, Hayakawa S, Yanagimoto T, Kobayakawa M, Nakagawa A, Tsuchida E. Bull. Chem. Soc. Jpn. 2001, 74, 1703. DOI: 10.1246/bcsj.74.1703] |
| 3 |
O2-Binding Properties of Double-Sided Porphinatoiron(II)s with Polar Substituents and their Human Serum Albumin Hybrids. Komatsu T, Okada T, Moritake M, Tsuchida E. Bull. Chem. Soc. Jpn. 2001, 74, 1695. [DOI: 10.1246/bcsj.74.1695] |
| 4 |
O2-Adduct Complex of meso-Tetrakis(α,α,α,α-o-Pivalamidophenyl)porphinatoiron(II) with an Intramolecularly Coordinated Proximal Histidine. Komatsu T, Matsukawa Y, Miyatake K, Tsuchida E. Chem. Lett. 2001, 668. [DOI: 10.1246/cl.2001.668] |
| 5 |
Photoreduction of Autooxidized Albumin-Home Hybrid in Saline Solution: Revival of its O2-Binding Ability. Nakagawa A, Komatsu T, Tsuchida E. Bioconjugate Chem. 2001, 12, 648. [DOI: 10.1021/bc000106j] |
| 6 |
Reaction of nitric oxide with synthetic hemoprotein, human serum albumin incorporating tetraphenylporphinatoiron(II) derivatives. Komatsu T, Matsukawa Y, Tsuchida E. Bioconjugate Chem. 2001, 12, 71. [DOI: 10.1021/bc000067b] |
| 7 |
Electrochemical studies of albumin-heme hybrid in aqueous media by modified electrode. Wu YP, Komatsu T, Tsuchida E. Inorg. Chim. Acta 2001, 322, 120. [DOI: 10.1016/S0020-1693(01)00579-5] |