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Publication (2009)
(2009) 2008 2007 2006 2005 2004 2003 2002 2001
Article about Oxygen Infusion
| 1 |
Artificial Oxygen Carriers, Hemoglobin Vesicles and Albumin-Hemes, Based on Bioconjugate Chemistry. Tsuchida E, Sou K, Nakagawa A, Sakai H, Komatsu T, Kobayashi K. Bioconjugate Chem. (in press). [DOI: 10.1021/bc800431d] |
Hemoglobin Vesicle
| 1 |
Pharmacokinetic analysis of hemoglobin vesicles for red blood cell substitution in a rat model of hemorrhagic shock. K. Taguchi, T. Maruyama, Y. Iwao, H. Sakai, K. Kobayashi, H. Horinouchi, E. Tsuchida, T. Kai, M. Otagiri. J. Controlled Release (in press). |
| 2 |
Effect of hemoglobin vesicles, cellular-type artificial oxygen carriers, on the ex vivo expansion of human hematopoietic stem/progenitor cells using a coculture system with human stromal cells. M. Yamaguchi, M. Fujihara, S. Wakamoto, H. Sakai, E. Tsuchida, H. Azuma, H. Ikeda. ASAIO J. (in press). |
| 3 |
Effect of hemoglobin vesicles, cellular-type artificial oxygen carriers, on the ex vivo expansion of human hematopoietic stem/progenitor cells using a coculture system with human stromal cells. M. Yamaguchi, M. Fujihara, S. Wakamoto, H. Sakai, E. Tsuchida, H. Azuma, H. Ikeda. ASAIO J. (in press). |
| 4 |
Hemoglobin-vesicle, a cellular artificial oxygen carrier, that fulfils the physiological roles of the red blood cells structure. H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida. Adv. Exp. Med. Biol. (in press). |
| 5 |
Characterization and Cytotoxicity of Self-Organized Assemblies of Curcumin and Amphiphatic Poly(Ethylene Glycol). Sou K, Oyajobi BO, Goins B, Phillips WT, Tsuchida E. J. Biomed. Nanotechnol. (in press). |
| 6 |
Hemoglobin-Vesicles and Red Blood Cells as Carriers of Carbon Monoxide Prior to Oxygen for Resuscitation after Hemorrhagic Shock in a Rat Model. Sakai H, Horinouchi H, Kobayashi K, Tsuchida E. Shock (in press). |
| 7 |
Review of Hemoglobin-Vesicles as Artificial Oxygen Carriers. Sakai H, Sou K, Horinouchi H, Kobayashi K, Tsuchida E. Artif. Organs 2009, 33, 139. [DOI: 10.1111/j.1525-1594.2008.00698.x] |
| 8 |
Fluid Resuscitation with Artificial Oxygen Carriers in Hemorrhaged Rats: Profiles of Hb-Vesicles Degradation and Hematopoiesis for 14 days. Sakai H, Seishi Y, Obata Y, Takeoka S, Horinouchi H, Tsuchida E, Kobayashi K. Shock 2009, 31, 192. [DOI: 10.1097/SHK.0b013e31817d4066] |
| 9 |
Histopathological Changes of Rat Brain after Direct Injection of Hemoglobin-Vesicles (Oxygen Carriers) and Neurological Impact in an Intracerebral Hemorrhage Model. Sakai H, Okamoto M, Ikeda E, Horinouchi H, Kobayashi K, Tsuchida E. J. Biomed. Mater. Res. A (in press). [DOI: 10.1002/jbm.a.32164] |
| 10 |
Influence of Hemoglobin Vesicles, Cellular-Type Artificial Oxygen Carriers, on Human Umbilical Cord Blood Hematopoietic Progenitor Cells in vitro. Yamaguchi M, Fujihara M, Wakamoto S, Sakai H, Takeoka S, Tsuchida E, Hamada H, Azuma H, Ikeda H. J. Biomed. Mater. Res. A 2009, 88A, 34. [DOI: 10.1002/jbm.a.31857] |
| 11 |
Systemic Administration of Hemoglobin Vesicles Elevates Tumor Tissue Oxygen Tension and Modifies Tumor Response to Irradiation. Yamamoto M, Izumi Y, Horinouchi H, Teramura Y, Sakai H, Kohno M, Watanabe M, Adachi T, Ikeda E, Takeoka S, Tsuchida E, Kobayashi K. J. Surg. Res. 2009, 151, 48. [DOI: 10.1016/j.jss.2007.12.770] |
Publication (2008)
2009 (2008) 2007 2006 2005 2004 2003 2002 2001
Hemoglobin Vesicle
| 1 |
Generation of Functional Erythrocytes from Human Embryonic Stem Cell-Derived Definitive Hematopoiesis. Ma F, Ebihara Y, Umeda K, Sakai H, Hanada S, Zhang H, Zaike Y, Tsuchida E, Nakahata T, Nakauchi H, Tsuji K. Proc. Natl. Acad. Sci. U. S. A. 2008, 105, 13087. [DOI: 10.1073/pnas.0802220105] |
| 2 |
The Role of Luminal Factors in the Recovery of Gastric Function and Behavioral Changes after Chronic Helicobacter Pylori Infection. Verdu EF, Bercik P, Huang XX, Lu J, Al-Mutawaly N, Sakai H, Tompkins TA, Croitoru K, Tsuchida E, Perdue M, Collins SM. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 295, G664 [DOI: 10.1152/ajpgi.90316.2008] |
| 3 |
NO and CO Binding Profiles of Hemoglobin-Vesicles as Artificial Oxygen Carriers. Sakai H, Sato A, Sobolewski P, Takeoka S, Frangos JA, Kobayashi K, Intaglietta M, Tsuchida E. Biochim. Biophys. Acta. 2008, 1784, 1441. [DOI: 10.1016/j.bbapap.2008.03.007] |
| 4 |
Haemoglobin-Vesicles as Artificial Oxygen Carriers: Present Situation and Future Visions. Sakai H, Sou K, Horinouchi H, Kobayashi K, Tsuchida E. J. Intern. Med. 2008, 263, 4. [DOI: 10.1111/j.1365-2796.2007.01893.x] |
| 5 |
Encapsulation of Concentrated Hemoglobin Solution in Phospholipid Vesicles Retards the Reaction with NO, but not CO, by Intracellular Diffusion Barrier. Sakai H, Sato A, Masuda K, Takeoka S, Tsuchida E. J. Biol. Chem. 2008, 283, 1508. [DOI: 10.1074/jbc.M7076602003] |
| 6 |
Electrostatic Interactions and Complement Activation on the Surface of Phospholipid Vesicle Containing Acidic Lipids: Effect of the Structure of Acidic Groups. Sou K, Tsuchida E. Biochim. Biophys. Acta 2008, 1778, 1035. [DOI: 10.1016/j.bbamem.2008.01.006] |
| 7 |
Loading of Curcumin into Macrophages Using Lipid-Based Nanoparticles. Sou K, Inenaga S, Takeoka S, Tsuchida E. Int. J. Pharm. 2008, 352, 287. [DOI: 10.1016/j.ijpharm.2007.10.033] |
| 8 |
Topics: “Cerebral oxygen delivery by liposome-encapsulated hemoglobin: A positron-emission tomographic evaluation in a rat model of hemorrhagic shock” by Awasthi et al. Sou K. Artifi. Blood. 2008, 16, 169. |
Albumin-Heme
| 1 |
Protein Nanotubes Comprised of an Alternate Layer-by-Layer Assembly using a Polycation as an Electrostatic Glue. Qu X, Lu G, Tsuchida E, Komatsu T. Chem. Eur. J. 2008, 14, 10303. [DOI: 10.1002/chem.200800771] |
| 2 | Human Serum Albumin Nanotubes Comprising Layer-by-Layer Assembly with Polycation. Lu G, Tsuchida E, Komatsu T. Chem. Lett. 2008, 37, 972. [DOI: 10.1246/cl.2008.972] |
| 3 |
Structure, Photophysical Property, and Cytotoxicity of Human Serum Albumin Complexed with Tris(Dicarboxymethylene)[60]Fullerene. Qu X, Komatsu T, Sato T, Glatter O, Horinouchi H, Kobayashi K, Tsuchida E. Bioconjugate Chem. 2008, 19, 1556. [DOI: 10.1021/bc800207j] |
| 4 |
Enhanced Radiation Response of a Solid Tumor with the Artificial Oxygen Carrier ‘Albumin-Heme’. Horinouchi H, Yamamoto H, Komatsu T, Huang Y, Tsuchida E, Kobayashi K. Cancer Sci. 2008, 99, 1274. [DOI: 10.1111/j.1349-7006.2008.00811.x] |
| 5 |
O2 Binding to Human Serum Albumin Incorporating Iron Porphyrin with a Covalently Linked Methyl-L-Histidine Isomer. Nakagawa A, Iizuka M, Komatsu T, Tsuchida E. Bioconjugate Chem. 2008, 19, 581. [DOI: 10.1021/bc700400n] |
Publication (2007)
2009 2008 (2007) 2006 2005 2004 2003 2002 2001
Hemoglobin Vesicle
| 1 |
Rheological Properties of Hemoglobin Vesicles (Artificial Oxygen Carriers) Suspended in a Series of Plasma-Substitute Solutions. Sakai H, Sato A, Takeoka S, Tsuchida E. Langmuir 2007, 23, 8121. [DOI: 10.1021/la7004503] |
| 2 |
Effects of Hemoglobin Vesicles, a Liposomal Artificial Oxygen Carrier, on Hematological Responses, Complement and Anaphylactic Reactions in Rats. Abe H, Azuma H, Yamaguchi M, Fujihara M, Ikeda H, Sakai H, Takeoka S, Tsuchida E. Artif. Cells Blood Substit. Biotechnol. 2007, 35, 157. [DOI: 10.1080/10731190601188224] |
| 3 |
Selective Uptake of Surface-Modified Phospholipid Vesicles by Bone Marrow Macrophages in vivo. Sou K, Goins B, Takeoka S, Tsuchida E, Phillips WT. Biomaterials 2007, 28, 2655. [DOI: 10.1016/j.biomaterials.2007.01.041] |
| 4 |
One-Year Observation of Wistar Rats after Intravenous Infusion of Hemoglobin-Vesicles (Artificial Oxygen Carriers). Sakai H, Tsuchida E, Horinouchi H, Kobayashi K. Artif. Cells Blood Substit. Biotechnol. 2007, 35, 81. [DOI: 10.1080/10731190600974582] |
| 5 |
Hemoglobin Vesicles Reduce Hypoxia-Related Inflammation in Critically Ischemic Hamster Flap Tissue. Plock JA, Tromp AE, Contaldo C, Spanholtz T, Sinovcic D, Sakai H, Tsuchida E, Leunig M, Banic A, Erni D. Crit. Care. Med., 2007, 35, 899. [DOI: 10.1097/01.CCM.0000257463.71761.97] |
| 6 |
Poly(Ethylene Glycol)-Conjugated Phospholipids in Aqueous Micellar Solutions: Hydration, Static Structure, and Interparticle Interactions. Sato T, Sakai H, Sou K, Buchner R, Tsuchida E. J. Phys. Chem. B 2007, 111, 1393. [DOI: 10.1021/jp067011k] |
| 7 |
Hemoglobin-Vesicles for a Transfusion Alternative and Targeted Oxygen Delivery. Sakai H, Tsuchida E. J. Liposome Res. 2007, 17, 227. [DOI: 10.1080/08982100701529904] |
| 8 |
Solution to the Problems of Acellular Hbs by Encapsulation, and the Intrinsic Issues of Hb-Vesicles as a Molecular Assembly. Sakai H, Sou K, Tsuchida E. Trans. Altern. Trans. Med. 2007, 9, 226. [DOI: 10.1111/j.1778-428X.2007.00089.x] |
| 9 |
Hemoglobin Vesicles to Treat Hypoxia in Critically Ischemic Tissue. Erni D, Wettstein R, Contaldo C, Plock J, Rafatmehr N, Sakai H, Tsuchida E. Artifi. Blood 2007, 15, 58. |
Albumin-Heme
| 1 |
Nakagawa A, Komatsu T, Huang Y, Lu G, Tsuchida E. O2-Binding Albumin Thin Films: Solid Membranes of Poly(Ethylene Glycol)-Conjugated Human Serum Albumin Incorporating Iron Porphyrin. Bioconjugate Chem. 2007, 18, 1673. [DOI: 10.1021/bc070086m] |
| 2 |
Komatsu T, Nakagawa A, Zunszain PA, Curry S, Tsuchida E. Genetic Engineering of the Heme Pocket in Human Serum Albumin: Modulation of O2 Binding of Iron Protoporphyrin IX by Variation of Distal Amino Acids. J. Am. Chem. Soc. 2007, 129, 11286. [DOI: 10.1021/ja074179q] |
| 3 |
Artificial Hemoprotein Nanotubes. Lu G, Komatsu T, Tsuchida E. Chem. Commun. 2007, 28, 2980. [DOI: 10.1039/b704135g] |
| 4 |
meso-Tetrakis(α,α,α,α-o-amidophenyl)porphinatoiron(II) Bearing a Proximal Histidyl Group at the β-Pyrrolic Position via an Acyl Bond: Synthesis and O2 Coordination in Aqueous Media. Nakagawa A, Komatsu T, Tsuchida E. Chem. Lett. 2007, 36, 640. [DOI: 10.1246/cl.2007.640] |
| 5 |
Influence of O2-Carrying Plasma Hemoprotein "Albumin-Heme" on Complement System and Platelet Activation in vitro and Physiological Responses to Exchange Transfusion. Komatsu T, Huang YB, Wakamoto S, Abe H, Fujihara M, Azuma H, Ikeda H, Yamamoto H, Horinouchi H, Kobayash K, E. Tsuchida. J. Biomed. Mater. Res. A 2007, 81A, 821. [DOI: 10.1002/jbm.a.31016] |
| 6 |
Induced Long-Range Attractive Potentials of Human Serum Albumin by Ligand Binding. Sato T, Komatsu T, Nakagawa A, Tsuchida E. Phys. Rev. Lett. 2007, 98, 208101-1-4. [DOI: 10.1103/PhysRevLett.98.208101] |
Publication (2006)
2009 2008 2007 (2006) 2005 2004 2003 2002 2001
Hemoglobin Vesicle
| 1 |
Hemoglobin-Vesicles as a Transfusion Alternative. Tsuchida E, Sakai H, Horinouchi H, Kobayashi K. Artif. Cells Blood Substit. Biotechnol. 2006, 34, 581. [DOI: 10.1080/10731190600973907] |
| 2 |
Hemoglobin Vesicles Containing Methemoglobin and L-Tyrosine to Suppress Methemoglobin Formation in vitro and in vivo. Atoji T, Aihara M, Sakai H, Tsuchida E, Takeoka S. Bioconjugate Chem. 2006, 17, 1241. [DOI: 10.1021/bc050349h] |
| 3 |
Performances of PEG-Modified Hemoglobin-Vesicles as Artificial Oxygen Carriers in Microcirculation. Sakai H, Tsuchida E. Clin. Hemorheol. Microcirc. 2006, 34, 335. |
| 4 |
Acute 40 percent exchange-transfusion with hemoglobin-vesicles (HbV) suspended in recombinant human serum albumin solution: degradation of HbV and erythropoiesis in a rat spleen for 2 weeks. Sakai H, Horinouchi H, Yamamoto M, Ikeda E, Takeoka S, Takaori M, Tsuchida E, Kobayashi K. Transfusion 2006, 46, 339. [DOI: 10.1111/j.1537-2995.2006.00727.x] |
| 5 |
Fluid Resuscitation with Hemoglobin-Vesicle Solution Does not Increase Hypoxia or Inflammatory Responses in Moderate Hemorrhagic Shock. Goto Y, Terajima K, Tsueshita T, Miyashita M, Horinouchi H, Sakai H, Tsuchida E, Sakamoto A. Biomed. Res. 2006, 27, 283. [DOI: 10.2220/biomedres.27.283] |
(Book)
| 1 | Blood Substitutes; Sakai H, Tsuchida E. In: Wiley Encyclopedia of Biomedical Engineering. Akay M. (Ed.) 2006, 613-621, John Wiley & Sons, Inc., Hoboken, NJ. |
| 2 | Blood Substitutes Efficacy: Microvascular and Theological Determinants. Tsai AG, Cabrales P, Sakai H, Intaglietta M. In: Microvascular Research: Biology and Pathology, Vol. 2. (Ed: Shepro D), 2006, 1095-1103, San Diego: Elsevier. |
| 3 | Hemoglobin-Vesicles as a Molecular Assembly: Characteristics of Preparation Process and Performances as Artificial Oxygen Carriers. Sakai H, Sou K, Takeoka S, Kobayashi K,Tsuchida E. In Blood Substitutes Chapt. 44, (Ed. By Winslow RM), 2006, 514-522, Elsevier. |
Albumin-Heme
| 1 |
Photosensitized Reduction of Water to Hydrogen Using Human Serum Albumin Complexed with Zinc-Protoporphyrin IX. Komatsu T, Wang RM, Zunszain PA, Curry S, Tsuchida E. J. Am. Chem. Soc. 2006 128, 16297. [DOI: 10.1021/ja0656806] |
| 2 |
PEGylated Albumin-Heme as an Oxygen-Carrying Plasma Expander: Exchange Transfusion into Acute Anemia Rat Model. Huang Y, Komatsu T, Yamamoto H, Horinouchi H, Kobayashi K, Tsuchida E. Biomaterials 2006 27, 4477. [DOI: 10.1016/j.biomaterials.2006.04.008] |
| 3 |
Huang YB, Komatsu T, Wang RM, Nakagawa A, Tsuchida E. Poly(Ethylene Glycol)-Conjugated Human Serum Albumin Including Iron Porphyrins: Surface Modification Improves the O2-Transporting Ability. Bioconjugate Chem. 2006 17, 393. [DOI: 10.1021/bc050315+] |
| 4 |
Human serum albumin hybrid incorporating tailed porphyrinatoiron(II) in the α,α,α,β-conformer as an O2-binding site. Nakagawa A, Komatsu T, Iizuka M, Tsuchida E. Bioconjugate Chem. 2006 17, 146. [DOI: 10.1021/bc050154+] |
(Book)
| 1 | Albumin-Heme: A Synthetic Heme-Based Oxygen Carrier. T. Komatsu, Y. Huang, H. Yamamoto, H. Horinouchi H, Kobayashi K, Tsuchida E. In Blood Substitutes Chapt. 44, (Ed. By Winslow RM), 2006, 532-539, Elsevier |
Publication (2005)
2009 2008 2007 2006 (2005) 2004 2003 2002 2001
Article and Book about Oxygen Infusion
| 1 |
Oxygen Infusions (Hemoglobin-Vesicles and Albumin-Hemes) Based on Nano-Molecular Sciences. Tsuchida E, Sakai H, Komatsu T, Takeoka S, Huang Y, Sou K, Nakagawa A, Teramura Y, Kobayashi K. Polym. Adv. Tec. 2005, 16, 73. [DOI: 10.1002/pat.559] |
| 2 |
Safety and Efficacy of Hemoglobin-Vesicles and Albumin-Hemes. Kobayashi K, Horinouchi H, Watanabe M, Izumi Y, Teramura Y, Nakagawa A, Huang Y, Sou K, Sakai H, Komatsu T, Takeoka S, Tsuchida E. In: Artificial Oxygen Carrier: Its Front Line, Keio University International Symposia for Life Sciences and Medicine Vol.12, Eds. by K. Kobayashi, E. Tsuchida, H. Horinouchi; 2005, 1-21 Springer-Verlag. |
Hemoglobin Vesicle
| 1 |
Is Hemoglobin in Hemoglobin Vesicles Infused for Isovolemic Hemodilution Necessary to Improve Oxygenation in Critically Ischemic Hamster Skin? Plock JA, Contaldo C, Sakai H, Tsuchida E, Leunig M, Banic A, Menger MD, Erni D. Am. J. Physiol. Heart Circ. Physiol. 2005, 289, H2624. [DOI: 10.1152/ajpheart.00308.2005] |
| 2 |
Oxygen Release from Low and Normal P50 Hb Vesicles in Transiently Occluded Arterioles of the Hamster Window Model. Sakai H, Cabrales P, Tsai AG, Tsuchida E, Intaglietta M. Am. J. Physiol. Heart Circ. Physiol. 2005, 288, H2897. [DOI: 10.1152/ajpheart.01184.2004] |
| 3 |
New Generation of Hemoglobin-Based Oxygen Carriers Evaluated for Oxygenation of Critically Ischemic Hamster Flap Tissue. Contaldo C, Plock J, Sakai H, Takeoka S, Tsuchida E, Leunig M, Banic A, Erni D. Crit. Care Med., 2005, 33, 806. [DOI: 110.1097/01.CCM.0000159195.12111.CE] |
| 4 |
Oxygen Transport by Low and Normal Oxygen Affinity Hemoglobin Vesicles in Extreme Hemodilution. Cabrales P, Sakai H, Tsai AG, Takeoka S, Tsuchida E, Intaglietta M. Am. J. Physiol. Heart Circ. Physiol. 2005, 288, H1885. [DOI: 10.1152/ajpheart.01004.2004] |
| 5 |
Circulation Kinetics and Organ Distribution of Hb-Vesicles Developed as a Red Blood Cell Substitute. Sou K, Klipper R, Goins B, Tsuchida E, Phillips WT. J. Pharm. Exp. Ther. 2005, 312, 702. [DOI: 10.1124/jpet.104.074534] |
(Book)
| 1 | Hemoglobin-vesicles (HbV) as Artificial Oxygen Carriers. Sakai H, Sou K, Takeoka S, Kobayashi K, Tsuchida E. In: Artificial Oxygen Carrier: Its Front Line, Keio University International Symposia for Life Sciences and Medicine Vol.12. Eds. by Kobayashi K, Tsuchida E, Horinouchi H; 2005, 135-168, Springer-Verlag. |
Albumin-Heme
| 1 |
O2 and CO Binding Properties of Artificial Hemoproteins Formed by Complexing Iron Protoporphyrin Ix with Human Serum Albumin Mutants. Komatsu T, Ohmichi N, Nakagawa A, Zunszain PA, Curry S, Tsuchida E. J. Am. Chem. Soc., 2005, 127, 15933. [DOI: 10.1021/ja054819u] |
| 2 |
Albumin clusters: Structurally defined protein tetramer and oxygen carrier including thirty-two iron(II) porphyrins. Komatsu T, Oguro Y, Nakagawa A, Tsuchida E. Biomacromolecules, 2005, 6, 3397. [DOI: 10.1021/bm050454u] |
| 3 |
Heat-resistant oxygen-carrying hemoproteins consist of recombinant xylanases and synthetic iron(II) porphyrin. Komatsu T, Ishihara S, Tsuchida E, Nishide H, Morokuma C, Nakamura S. Biomacromolecules, 2005, 6, 1489. [DOI: 10.1021/bm049255l] |
| 4 |
Human Serum Albumin Bearing Covalently Attached Iron(Ii) Porphyrins as O2-Coordination Sites. Wang RM, Komatsu T, Nakagawa A, Tsuchida E. Bioconjugate Chem. 2005, 16, 23. [DOI: 10.1021/bc049859m] |
(Book)
| 1 | Komatsu T, Tsuchida E. Oxygen-Carrying Plasma Hemoprotein Including Synthetic Heme. In: Artificial Oxygen Carrier: Its Front Line, Keio University International Symposia for Life Sciences and Medicine Vol.12. Eds. by Kobayashi K, Tsuchida E, Horinouchi H; 2005, 193-204, Springer-Verlag. |
Publication (2004)
2009 2008 2007 2006 2005 (2004) 2003 2002 2001
Hemoglobin Vesicle
| 1 |
Physiological Capacity of the Reticuloendothelial System for the Degradation of Hemoglobin Vesicles (Artificial Oxygen Carriers) after Massive Intravenous Doses by Daily Repeated Infusions for 14 Days. Sakai H, Masada Y, Horinouchi H, Ikeda E, Sou K, Takeoka S, Suematsu M, Takaori M, Kobayashi K, Tsuchida E. J. Pharm. Exp. Ther. 2004, 311, 874. [DOI: 10.1124/jpet.104.073049] |
| 2 |
Hemorrhagic Shock Resuscitation with an Artificial Oxygen Carrier, Hemoglobin Vesicle, Maintains Intestinal Perfusion and Suppresses the Increase in Plasma Tumor Necrosis Factor-α. Yoshizu A, Izumi Y, Park S, Sakai H, Takeoka S, Horinouchi H, Ikeda E, Tsuchida E, Kobayashi K. ASAIO J. 2004, 50, 458. [DOI: 10.1097/01.MAT.0000136508.51676.EF] |
| 3 |
Reduction of methemoglobin via electron transfer from photoreduced flavin: Restoration of O2-binding of concentrated hemoglobin solution coencapsulated in phospholipid vesicles. Sakai H, Masada Y, Onuma H, Takeoka S, Tsuchida E. Bioconjugate Chem. 2004, 15, 1037. [DOI: 10.1021/bc049913z] |
| 4 |
Metabolism of Hemoglobin-Vesicles (Artificial Oxygen Carriers) and Their Influence on Organ Functions in a Rat Model. Sakai H, Horinouchi H, Masada Y, Takeoka S, Ikeda E, Takaori M, Kobayashi K, Tsuchida E. Biomaterials 2004, 25, 4317. [DOI: 10.1016/j.biomaterials.2003.11.005] |
| 5 |
Hemoglobin-Vesicles Suspended in Recombinant Human Serum Albumin for Resuscitation from Hemorrhagic Shock in Anesthetized Rats. Sakai H, Masada Y, Horinouchi H, Yamamoto M, Ikeda E, Takeoka S, Kobayashi K, Tsuchida E. Crit. Care Med. 2004, 32, 539. [DOI: 10.1097/01.CCM.0000109774.99665.22] |
| 6 |
Detection of lipopolysaccharide in hemoglobin-vesicles by Limulus amebocyte lysate test with kinetic-turbidimetric gel clotting analysis and pretreatment of surfactant. Sakai H, Hisamoto S, Fukutomi I, Sou K, Takeoka S, Tsuchida E. J. Pharm. Sci. 2004, 93, 310. [DOI: 10.1002/jps.10525] |
| 7 |
An Effective Blood Substitutes That Targets Oxygen Delivery, Increases Plasma Viscosity, and Has High Oxygen Affinity. Tsai AG, Sakai H, Wettstein R, Kerger H, Intaglietta M. Trans. Altern. Trans. Med. 2004, 5, 507. [DOI: 10.1111/j.1778-428X.2004.tb00089.x] |
Albumin-Heme
| 1 |
Safety Evaluation of an Artificial O2 Carrier as a Red Blood Cell Substitute by Blood Biochemical Tests and Histopathology Observations. Huang YB, Komatsu T, Yamamoto H, Horinouchi H, Kobayashi K, Tsuchida E. ASAIO J. 2004, 50, 525. |
| 2 |
Exchange Transfusion with Synthetic Oxygen-Carrying Plasma Protein "Albumin-Heme" Into an Acute Anemia Rat Model after Seventy-Percent Hemodilution. Komatsu T, Yamamoto H, Huang YB, Horinouchi H, Kobayashi K, Tsuchida E. J. Biomed. Mater. Res. A 2004, 71A, 644. [DOI: 10.1002/jbm.a.30200] |
| 3 |
Physicochemical Characterization of Cross-Linked Human Serum Albumin Dimer and its Synthetic Heme Hybrid as an Oxygen Carrier. Komatsu T, Oguro Y, Teramura Y, Takeoka S, Okai J, Anraku M, Otagiri M, Tsuchida E. Biochim. Biophys. Acta 2004, 1675, 21. [DOI: 10.1016/j.bbagen.2004.08.010] |
| 4 |
Dioxygenation of Human Serum Albumin Having a Prosthetic Heme Group in a Tailor-Made Heme Pocket. Komatsu T, Ohmichi N, Zunszain PA, Curry S, Tsuchida E. J. Am. Chem. Soc. 2004, 126, 14304. [DOI: 10.1021/ja046022t] |
| 5 |
Synthesis of protoheme IX Derivatives with a Covalently Linked Proximal Base and their Human Serum Albumin Hybrids as Artificial Hemoprotein. Nakagawa A, Ohmichi N, Komatsu T, Tsuchida E. Org. Biomol. Chem. 2004, 2, 3108. [DOI: 10.1039/b409017a] |
| 6 |
Exchange Transfusion with Entirely Synthetic Red-Cell Substitute Albumin-Heme into Rats: Physiological Responses and Blood Biochemical Tests. Huang YB, Komatsu T, Yamamoto H, Horinouchi H, Kobayashi K, Tsuchida E. J. Biomed. Mater. Res. A 2004, 71A, 63. [DOI: 10.1002/jbm.a.30127] |
Publication (2003)
2009 2008 2007 2006 2005 2004 (2003) 2002 2001
Hemoglobin Vesicle
| 1 |
Prolonged Oxygen-Carrying Ability of Hemoglobin Vesicles by Coencapsulation of Catalase in vivo. Teramura Y, Kanazawa H, Sakai H, Takeoka S, Tsuchida E. Bioconjugate Chem. 2003, 14, 1171. [DOI: 10.1021/bc0340619] |
| 2 |
O2 Release from Hb Vesicles Evaluated Using an Artificial, Narrow O2-Permeable Tube: Comparison with RBCs and Acellular Hbs. Sakai H, Suzuki Y, Kinoshita M, Takeoka S, Maeda N, Tsuchida E. Am. J. Physiol. Heart Circ. Physiol. 2003, 285, H2543. [DOI: 10.1152/ajpheart.00537.2003] |
| 3 |
Effective Encapsulation of Proteins into Size-Controlled Phospholipid Vesicles Using Freeze-Thawing and Extrusion. Sou K, Naito Y, Endo T, Takeoka S, Tsuchida E. Biotech. Prog. 2003, 19, 1547. [DOI: 10.1021/bp0201004] |
| 3 |
Improved Oxygenation in Ischemic Hamster Flap Tissue is Correlated with Increasing Hemodilution with Hb Vesicles and their O2 Affinity. Contaldo C, Schramm S, Wettstein R, Sakai H, Takeoka S, Tsuchida E, Leunig M, Banic A, Erni D. Am. J. Physiol. Heart Circ. Physiol. 2003, 285, H1140. [DOI: 10.1152/ajpheart.00285.2003] |
| 4 |
Normovolemic Hemodilution with Hb Vesicle Solution Attenuates Hypoxia in Ischemic Hamster Flap Tissue. Erni D, Wettstein R, Schramm S, Contaldo C, Sakai H, Takeoka S, Tsuchida E, Leunig M, Banic A. Am. J. Physiol. Heart Circ. Physiol. 2003, 284, H1702. [DOI: 10.1152/ajpheart.00821.2002] |
| 5 |
Pretreatment of Serum Containing Hemoglobin Vesicles (Oxygen Carriers) to Prevent their Interference in Laboratory Tests. Sakai H, Tomiyama K, Masada Y, Takeoka S, Horinouchi H, Kobayashi K, Tsuchida E. Clin. Chem. Lab. Med. 2003, 41, 222. |
| 6 |
Oxygen Affinity of Hemoglobin Regulates O2 Consumption, Metabolism, and Physical Activity. Shirasawa T, Izumizaki M, Suzuki Y, Ishihara A, Shimizu T, Tamaki M, Huang F, Koizumi K, Iwase M, Sakai H, Tsuchida E. J. Biol. Chem. 2003, 278, 5035-5043. [DOI: 10.1074/jbc.M211110200] |
Albumin-Heme
| 1 |
Oxygen-Carrying Plasma Hemoprotein "Albumin-Heme": Nitric Oxide Binding and Physiological Responses after Administration in vivo. Tsuchida E, Komatsu T. Macromol. Symp. 2003, 204, 13. [DOI: 10.1002/masy.200351402] |
| 2 |
Microcalorimetry Investigation of Synthetic Hemoprotein (Albumin-Heme). Huang YB, Komatsu T, Tsuchida E. Polym. Adv. Tec. 2003, 14, 729. [DOI: 10.1002/pat.418] |
| 3 |
Molecular Energy and Electron Transfer Assemblies Made of Self-Organized Lipid-Porphyrin Bilayer Vesicles. Komatsu T, Moritake M, Tsuchida E. Chem. Eur. J. 2003, 9, 4626. [DOI: 10.1002/chem.200305013] |
| 4 |
Compatibility in vitro of Albumin-Heme (O2 Carrier) with Blood Cell Components. Huang YB, Komatsu T, Nakagawa A, Tsuchida E, Kobayashi S. J. Biomed. Mater. Res. A 2003, 66A, 292. [DOI: 10.1002/jbm.a.10573] |
| 5 |
Coordination structure of active site in synthetic hemoprotein (albumin-heme) with dioxygen and carbon monoxide. Tsuchida E, Nakagawa A, Komatsu T. Macromol. Symp. 2003, 195, 275. [DOI: 10.1002/masy.200390134] |
| 6 |
Synthetic dioxygen-carrying hemoprotein. Human serum albumin including iron(II) complex of protoporphyrin IX with an axially coordinated histidylglycyl-propionate. Nakagawa A, Komatsu T, Ohmichi N, Tsuchida E. Chem. Lett. 2003, 32, 504. [DOI: 10.1246/cl.2003.504] |
| 7 |
Human Serum Albumin Incorporating Synthetic Heme: Red Blood Cell Substitute without Hypertension by Nitric Oxide Scavenging. Tsuchida E, Komatsu T, Matsukawa Y, Nakagawa A, Sakai H, Kobayashi K, Suematsu M. J. Biomed. Mater. Res. A 2003, 64A, 257. [DOI: 10.1002/jbm.a.10324] |
| 8 |
Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes. Kobayashi K, Komatsu T, Iwamaru A, Matsukawa Y, Horinouchi H, Watanabe M, Tsuchida E. J. Biomed. Mater. Res. A 2003, 64A, 48. [DOI: 10.1002/jbm.a.10323] |
Publication (2002)
2009 2008 2007 2006 2005 2004 2003 (2002) 2001
Hemoglobin Vesicle
| 1 |
Systemic and Microvascular Responses to Hemorrhagic Shock and Resuscitation with Hb Vesicles. Sakai H, Takeoka S, Wettstein R, Tsai AG, Intaglietta M, Tsuchida E. Am. J. Physiol. Heart Circ. Physiol. 2002, 283, H1191. [DOI: 10.1152/ajpheart.00080.2002] |
| 2 |
Model Mice for Presbyterian Hemoglobinopathy (Asn(β 108)-> Lys) Confer Hemolytic Anemia with Altered Oxygen Affinity and Instability of Hb. Suzuki Y, Shimizu T, Sakai H, Tamaki M, Koizumi K, Kuriyama T, Tsuchida E, Koseki H, Shirasawa T. Biochem. Biophys. Res. Commun. 2002, 295, 869. [DOI: 10.1016/S0006-291X(02)00752-0] |
| 3 |
Capillary Blood Flow during Severe Hemodilution Observed by a Noninvasive Transcutaneous Technique Using Flash Epi-Illumination. Sakai H, Sato T, Maekawa Y, Tsuchida E. Microvas. Res. 2002, 64, 120. [DOI: 10.1006/mvre.2002.2415] |
| 4 |
Virus Inactivation in Hemoglobin Solution by Heat Treatment. Abe H, Ikebuchi K, Hirayama J, Fujihara M, Takeoka S, Sakai H, Tsuchida E, Ikeda H. Artif. Cells Blood Substit. Immob. Biotechnol. 2002, 30, 79. |
| 5 |
Characteristics of Bovine Hemoglobin as a Potential Source of Hemoglobin-Vesicles for an Artificial Oxygen Carrier. Sakai H, Masada Y, Takeoka S, Tsuchida E. J. Biochem. 2002, 131, 611. |
| 6 |
Complete Deoxygenation from a Hemoglobin Solution by an Electrochemical Method and Heat Treatment for Virus Inactivation. Huang YB, Takeoka S, Sakai H, Abe H, Hirayama J, Ikebuchi K, Ikeda H, Tsuchida E. Biotechnol. Prog. 2002, 18, 101. [DOI: 10.1021/bp0101233] |
| 7 |
Virus Removal from Hemoglobin Solution Using Planova Membrane. Naito Y, Fukutomi I, Masada Y, Sakai H, Takeoka S, Tsuchida E, Abe H, Hirayama J, Ikebuchi K, Ikeda H. J. Artifi. Org. 2002, 5, 141. |
| 8 |
Carbonylation of Oxyhemoglobin Solution (HbO2 HbCO) Using a Membrane Oxygenator. Fukutomi I, Sakai H, Takeoka S, Tsuchida E, Sakai K. J. Artif. Org. 2002, 5, 102. |
Albumin-Heme
| 1 |
Self-Organized Lipid-Porphyrin Bilayer Membranes in Vesicular Form: Nanostructure, Photophysical Properties, and Dioxygen Coordination. Komatsu T, Moritake W, Nakagawa A, Tsuchida E. Chem. Eur. J. 2002, 8, 5469. [DOI: 10.1002/1521-3765(20021202)8:23<5469::AID-CHEM5469>3.0.CO;2-1] |
| 2 |
Human Serum Albumin Incorporating Synthetic Hemes as an O2-Carrying Hemoprotein: Control of O2-Binding Ability by Heme Structure. Tsuchida E, Komatsu T, Matsukawa Y, Okada T. Macromol. Symp. 2002, 186, 1. [DOI: 10.1002/1521-3900(200208)186:1<1::AID-MASY1>3.0.CO;2-M] |
| 3 |
Effect of heme structure on O2-binding properties of human serum albumin-heme hybrids: Intramolecular histidine coordination provides a stable O2-adduct complex. Komatsu T, Matsukawa Y, Tsuchida E. Bioconjugate Chem. 2002, 13, 397-402. [DOI: 10.1021/bc010067r] |
Publication (2001)
2009 2008 2007 2006 2005 2004 2003 2002 (2001)
Hemoglobin Vesicle
| 1 |
Effects of Poly(Ethyleneglycol)-Modified Hemoglobin Vesicles on N-Formyl-Methionyl-Leucylphenylalanine-Induced Responses of Polymorphonuclear Neutrophils in vitro. Ito T, Fujihara M, Abe H, Yamaguchi M, Wakamoto S, Takeoka S, Sakai H, Tsuchida E, Ikeda H, Ikebuchi K. Artif. Cells Blood Substit. Immobil. Biotechnol. 2001, 29, 427. [DOI: 10.1081/BIO-100108548] |
| 2 |
Virus Inactivation in Hemoglobin Solution by Heat Treatment. Abe H, Ikebuchi K, Hirayama J, Fujihara M, Takeoka S, Sakai H, Tsuchida E, Ikeda H. Artif. Cells Blood Substit. Immobil. Biotechnol. 2001, 29, 381. [DOI: 10.1081/BIO-100106921] |
| 3 |
Hemoglobin-Vesicles as Oxygen Carriers - Influence on Phagocytic Activity and Histopathological Changes in Reticuloendothelial System. Sakai H, Horinouchi H, Tomiyama K, Ikeda E, Takeoka S, Kobayashi K, Tsuchida E. Am. J. Pathol. 2001, 159, 1079. |
| 4 |
Effects of Poly(Ethyleneglycol)-Modified Hemoglobin Vesicles on Agonist-Induced Platelet Aggregation and Rantes Release in vitro. Wakamoto S, Fujihara M, Abe H, Sakai H, Takeoka S, Tsuchida E, Ikeda H, Ikebuchi K. Artif. Cells Blood Substit. Immobil. Biotechnol. 2001, 29, 191. [DOI: 10.1081/BIO-100103043] |
Albumin-Heme
| 1 |
Photoreduction of a Self-Assembled (Lipidporphyrinato)Iron(Iii) Complex in Saline by LMCT Excitation: Co-Aggregated Hyaluronic Acid Allows an Irreversible Electron Transfer. Yanagimoto T, Nakagawa A, Komatsu T, Tsuchida E. Bull. Chem. Soc. Jpn. 2001, 74, 2123. [DOI: 10.1246/bcsj.74.2123] |
| 2 |
Iron(II) Complex of Octopus-Porphyrin with a Covalently Linked Proximal Imidazole; Self-Assembly and O2-Coordination in Aqueous Media. Komatsu T, Hayakawa S, Yanagimoto T, Kobayakawa M, Nakagawa A, Tsuchida E. Bull. Chem. Soc. Jpn. 2001, 74, 1703. DOI: 10.1246/bcsj.74.1703] |
| 3 |
O2-Binding Properties of Double-Sided Porphinatoiron(II)s with Polar Substituents and their Human Serum Albumin Hybrids. Komatsu T, Okada T, Moritake M, Tsuchida E. Bull. Chem. Soc. Jpn. 2001, 74, 1695. [DOI: 10.1246/bcsj.74.1695] |
| 4 |
O2-Adduct Complex of meso-Tetrakis(α,α,α,α-o-Pivalamidophenyl)porphinatoiron(II) with an Intramolecularly Coordinated Proximal Histidine. Komatsu T, Matsukawa Y, Miyatake K, Tsuchida E. Chem. Lett. 2001, 668. [DOI: 10.1246/cl.2001.668] |
| 5 |
Photoreduction of Autooxidized Albumin-Home Hybrid in Saline Solution: Revival of its O2-Binding Ability. Nakagawa A, Komatsu T, Tsuchida E. Bioconjugate Chem. 2001, 12, 648. [DOI: 10.1021/bc000106j] |
| 6 |
Reaction of nitric oxide with synthetic hemoprotein, human serum albumin incorporating tetraphenylporphinatoiron(II) derivatives. Komatsu T, Matsukawa Y, Tsuchida E. Bioconjugate Chem. 2001, 12, 71. [DOI: 10.1021/bc000067b] |
| 7 |
Electrochemical studies of albumin-heme hybrid in aqueous media by modified electrode. Wu YP, Komatsu T, Tsuchida E. Inorg. Chim. Acta 2001, 322, 120. [DOI: 10.1016/S0020-1693(01)00579-5] |