Stab injury model of zebrafish
unveils regenerative
processes by neural stem
cells in the brain

Waseda University researchers recently elucidated the regenerative processes by neural stem cells using a stab injury model in the optic tectum, a less studied area of the brain, of adult zebrafish. This study has brought them a step closer to shedding light on how an injured, human central nervous system (CNS) could be restored.

“Unlike mammals, zebrafish have superior abilities to generate new neurons and to regenerate tissues in the brain after an injury, but surprisingly, their genes are said to be very similar to humans and mice,” explains Toshio Ohshima, professor of molecular neurobiology at Waseda. “There have even been reports on how the mechanism of zebrafish’s regenerative abilities could be applied to mice. This means that there is a possibility in which this same mechanism could be applied to humans as well.”

The study was published online in the scientific journal GLIA on February 7, 2018.