Oral bacteria in the gut could drive immune cell induction and inflammatory bowel disease

Professor Masahira Hattori of Waseda University and Professor Kenya Honda of Keio University School of Medicine led research to investigate the relationship between salivary microbes and IBD, and they found that when the bacterium Klebsiella pneumoniae colonizes in an intestine out of microbial balance, immune cells called T helper 1 (TH1) become overactive in the gut, resulting in intestinal inflammation leading to the onset of IBD. Their findings suggest a profound association between oral microbe and gut ecosystem, which provides new insights into microbiome research, and advance development of a novel type of medicine in therapeutics of chronic inflammatory diseases.

This study was published in the online version of Science on October 20.

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