Elucidating brain mechanism of pubertal disorders

Waseda University researchers are taking on one of the major themes in medical research, the hormonal mechanism that induces pubertal disorders, by investigating whether thyroid dysfunction affects pubertal onset.

“Elucidating how thyroid abnormalities have affected those who struggle from pubertal disorders will help develop effective treatment in the future and have major impact on society, says Professor Kazuyoshi Tsutsui of Waseda’s Center for Medical Life Science. Professor Tsutsui is known for discovering hypothalamic gonadotropin-inhibitory hormones (GnIH), which actively inhibit the secretion of gonadotropin-releasing hormone (GnRH). GnIH is, therefore, a negative regulator of reproduction.

This study, published in Scientific Reports, is the first evidence showing the involvement of GnIH in pubertal disorder induced by abnormal thyroid status.